N-ethyl-2,3-dimethylaniline | 41115-23-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-ethyl-2,3-dimethylaniline
• 英文别名: N-ethyl-2,3-dimethyl-aniline；N-Aethyl-2,3-dimethyl-anilin；Aethyl-vic.-o-xylidin；N-ethyl-2,3-xylidine
• CAS: 41115-23-5
• 化学式: C₁₀H₁₅N
• mdl: MFCD00009026
• 分子量: 149.236
• InChiKey: IILPUHXLVPEPAV-UHFFFAOYSA-N

物化性质

• 沸点：
  227.5±0.0 °C(Predicted)
• 密度：
  0.944±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2921430090

反应信息

• 作为反应物：
  描述：

  N-ethyl-2,3-dimethylaniline 以97%的产率得到
  参考文献：
  名称：

  MAHAFFY, CH. A. L., SYNTH. AND REACT. INORG. AND METAL-ORG. CHEM., 1984, 14, N 6, 895-903

  摘要：

  DOI：
• 作为产物：
  描述：

  N-Aethyl-N-(2,3-dimethyl-phenyl>-essigsaeureamid 在 硫酸 、 水 作用下， 生成 N-ethyl-2,3-dimethylaniline
  参考文献：
  名称：

  Menton, Justus Liebigs Annalen der Chemie, 1891, vol. 263, p. 333

  摘要：

  DOI：

文献信息

• [EN] UREA DERIVATIVES OF AMPHOTERICIN B DERIVED FROM SECONDARY AMINES<br/>[FR] DÉRIVÉS D'URÉE DE L'AMPHOTÉRICINE B DÉRIVÉE D'AMINES SECONDAIRES
  申请人：UNIV ILLINOIS

  公开号：WO2016112243A1

  公开（公告）日：2016-07-14

  Provided are certain urea derivatives of amphotericin B (AmB) having improved therapeutic index compared to AmB. The compounds of the invention are less toxic than AmB and are useful to treat fungal infections. In certain embodiments the urea derivative of AmB is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof: wherein, independently for each occurrence: R represents methyl, ethyl, propyl, or isopropyl; R' represents methyl, ethyl, propyl, or isopropyl; or R and R', taken together with the nitrogen atom to which they are attached, represent a radical of a cyclic secondary amine. Also provided are methods for making the urea derivatives of AmB.

  提供了与两性霉素B（AmB）相比具有改善的治疗指数的某些尿素衍生物。本发明的化合物比AmB毒性更小，并且可用于治疗真菌感染。在某些实施例中，AmB的尿素衍生物是由以下式（I）表示的化合物或其药用可接受的盐：其中，对于每次出现独立地：R代表甲基、乙基、丙基或异丙基；R'代表甲基、乙基、丙基或异丙基；或R和R'与它们连接的氮原子一起表示环状二级胺的基团。还提供了制备AmB的尿素衍生物的方法。
• [EN] AMINOBENZIMIDAZOLES AND BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION<br/>[FR] AMINOBENZIMIDAZOLES ET BENZIMIDAZOLES UTILISES EN TANT QU'INHIBITEURS DE LA REPLICATION DU VIRUS SYNCYTIAL RESPIRATOIRE
  申请人：TIBOTEC PHARM LTD

  公开号：WO2005058869A1

  公开（公告）日：2005-06-30

  Aminobenzimidazoles and benzimidazoles having inhibitory activity on RSV replication and having the formula (I) the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; wherein G is a direct bond or C1-10alkanediyl optionally substituted with one or more hydroxy, C1-6alkyloxy, Ar1Cl-6alkyloxy, C1-6alkylthio, Ar1C1-6alkylthio, HO(-CH2-CH2-O)n-, C1-6alkyloxy(-CH2-M2-O)n- or Ar1Cl-6alkyloxy(-CH2-C2-O)n-; R1 is Ar1 or a monocyclic or bicyclic heterocycle; Q is hydrogen, amino or mono- or di(C1-4alkyl)amino; one of R2a and R3a is selected from halo, optionally mono- or polysubstituted C1-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N(R4aR4b), N(R4aR4b)sulfonyl, N(R4aR4b)carbonyl, C1-6alkyloxy, Ar2oxy, Ar2C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl, or -C(=Z)Ar2; and the other one of R2a and R3a is hydrogen; in case R2a is different from hydrogen then R2b is hydrogen, C1-6alkyl or halogen and R3b is hydrogen; in case R3a is different from hydrogen then R3b is hydrogen, C1-6alkyl or halogen and R2b is hydrogen. Compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.

  氨基苯并咪唑和对RSV复制具有抑制活性的苯并咪唑，其具有式(I)的前药、N-氧化物、加合盐、季铵盐、金属配合物和立体化学异构体形式；其中G是直接键或C1-10烷二基，可选地取代一个或多个羟基、C1-6烷氧基、Ar1Cl-6烷氧基、C1-6烷基硫氧基、Ar1C1-6烷基硫氧基、HO(-CH2-CH2-O)n-、C1-6烷氧基(-CH2-M2-O)n-或Ar1Cl-6烷氧基(-CH2-C2-O)n-；R1是Ar1或单环或双环杂环；Q是氢、氨基或单或双(C1-4烷基)氨基；R2a和R3a中的一个选择自卤素、可选地单或多取代的C1-6烷基、可选地单或多取代的C2-6烯基、硝基、羟基、Ar2、N(R4aR4b)、N(R4aR4b)磺酰基、N(R4aR4b)羰基、C1-6烷氧基、Ar2氧基、Ar2C1-6烷氧基、羧基、C1-6烷氧羰基或-C(=Z)Ar2；R2a和R3a中的另一个是氢；如果R2a不同于氢，则R2b是氢、C1-6烷基或卤素，而R3b是氢；如果R3a不同于氢，则R3b是氢、C1-6烷基或卤素，而R2b是氢。含有这些化合物作为活性成分的组合物以及制备这些化合物和组合物的方法。
• [EN] COMBINATION THERAPY FOR TREATING A PARAMYXOVIRUS<br/>[FR] POLYTHÉRAPIE POUR TRAITER UN PARAMYXOVIRUS
  申请人：ALIOS BIOPHARMA INC

  公开号：WO2016022464A1

  公开（公告）日：2016-02-11

  Disclosed herein are a combination of compounds and methods of using the combination compounds for ameliorating, treating and/or preventing a paramyxovirus viral infection.

  本文披露了一种化合物组合以及使用该化合物组合来改善、治疗和/或预防副黏病毒感染的方法。
• Process for preparing N-methyldialkylamines from secondary dialkylamines and formaldehyde
  申请人：——

  公开号：US20040204611A1

  公开（公告）日：2004-10-14

  The present invention relates to a process for preparing N-methyldialkyl-amines by reacting secondary dialkylamines with formaldehyde at a temperature of from 100 to 200° C., by using from 1.5 to 3 mol of formaldehyde per mole of secondary dialkylamine and degassing the resulting reaction product, removing the aqueous phase and distilling the organic phase.

  本发明涉及一种制备N-甲基二烷基胺的方法，该方法通过在100至200℃的温度下使用每摩尔二级二烷基胺1.5至3摩尔的甲醛反应，并使得反应产物脱气，去除水相并蒸馏有机相。
• Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication
  申请人：Bonfanti Jean-Francois

  公开号：US20070099924A1

  公开（公告）日：2007-05-03

  Aminobenzimidazoles and benzimidazoles having inhibitory activity on RSV replication and having the formula the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof, wherein G is a direct bond or C 1-10 alkanediyl optionally substituted with one or more hydroxy, C 1-6 alkyloxy, Ar 1 C 1-6 alkyloxy, C 1-6 alkylthio, Ar 1 C 1-6 alkylthio, HO(—CH 2 —CH 2 —O) n —, C 1-6 alkyloxy(—CH 2 —CH 2 —O) n — or Ar 1 C 1-6 alkyloxy(—CH 2 —CH 2 —O) n —; R 1 is Ar 1 or a monocyclic or bicyclic heterocycle; Q is hydrogen, amino or mono- or di(C 1-4 alkyl)amino; one of R 2a and R 3a is selected from halo, optionally mono- or polysubstituted C 1-6 alkyl, optionally mono- or polysubstituted C 2-6 alkenyl, nitro, hydroxy, Ar 2 , N(R 4a R 4b ), N(R 4a R 4b )sulfonyl, N(R 4a R 4b )carbonyl, C 1-6 alkyloxy, Ar 2 oxy, Ar 2 C 1-6 alkyloxy, carboxyl, C 1-6 alkyloxycarbonyl, or —C(═Z)Ar 2 ; and the other one of R 2a and R 3a is hydrogen; in case R 2a is different from hydrogen then R 2b is hydrogen, C 1-6 alkyl or halogen and R 3b is hydrogen; in case R 3a is different from hydrogen then R 3b is hydrogen, C 1-6 alkyl or halogen and R 2b is hydrogen. Compositions containg these compounds as active ingredient and processes for preparing these compounds and compositions.

  具有RSV复制抑制活性的氨基苯并咪唑和苯并咪唑，其具有以下公式的前药，N-氧化物，加成盐，季铵盐，金属配合物和立体化学异构体形式，其中G是直接键或C1-10烷二基，可选地取代一个或多个羟基，C1-6烷氧基，Ar1C1-6烷氧基，C1-6烷基硫基，Ar1C1-6烷基硫基，HO（-CH2-CH2-O）n-，C1-6烷氧基（-CH2-CH2-O）n-或Ar1C1-6烷氧基（-CH2-CH2-O）n-; R1是Ar1或单环或双环杂环; Q是氢，氨基或单或双（C1-4烷基）氨基之一; R2a和R3a中的一个选自卤素，可选择单或多取代的C1-6烷基，可选择单或多取代的C2-6烯基，硝基，羟基，Ar2，N（R4aR4b），N（R4aR4b）磺酰基，N（R4aR4b）羰基，C1-6烷氧基，Ar2氧基，Ar2C1-6烷氧基，羧基，C1-6烷氧羰基或-C（═Z）Ar2; R2a和R3a中的另一个是氢; 在R2a不同于氢的情况下，R2b是氢，C1-6烷基或卤素，而R3b是氢; 在R3a不同于氢的情况下，R3b是氢，C1-6烷基或卤素，而R2b是氢。含有这些化合物作为活性成分的组合物以及制备这些化合物和组合物的过程。