3-chloro-4-ethenyl-N,N-dimethylaniline | 1254312-13-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-chloro-4-ethenyl-N,N-dimethylaniline
• CAS: 1254312-13-4
• 化学式: C₁₀H₁₂ClN
• 分子量: 181.665
• InChiKey: VYUHAPWAEUCFHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-chloro-4-ethenyl-N,N-dimethylaniline 、 Decylmagnesium bromide 在 iron(III)-acetylacetonate 作用下， 以 四氢呋喃 、 N-甲基吡咯烷酮 为溶剂， 反应 1.33h， 以73%的产率得到3-decyl-N,N-dimethyl-4-vinylaniline
  参考文献：
  名称：

  烯烃辅助铁催化的芳基氯化烷基化

  摘要：

  AbstractA selective and operationally simple iron‐catalyzed cross‐coupling of aryl chlorides with alkylmagnesium halides has been developed. The reaction tolerates various functional groups and exhibits high chemoselectivity even in the presence of aryl bromides. Mechanistic studies indicate the essential role of the olefin substituent for substrate activation. Competing polymerization and reduction are effectively suppressed.magnified image

  DOI：

  10.1002/adsc.201300095

文献信息

• Highly chemoselective cobalt-catalyzed biaryl coupling reactions
  作者：Samet Gülak、Ondrej Stepanek、Jennifer Malberg、Babak Rezaei Rad、Martin Kotora、Robert Wolf、Axel Jacobi von Wangelin

  DOI：10.1039/c2sc21667a

  日期：——

  cobalt-catalyzed hetero-biaryl coupling reaction between aryl chlorides and arylmagnesium halides with unprecedented selectivity has been developed. The protocol utilizes 1 mol% of cheap Co(acac)3 as pre-catalyst and effects clean reactions of deactivated chlorostyrenes with only 1.1 equiv. of the Grignard reagent under mild conditions (30 °C, 5–30 min). Highly chemoselective reactions were realized even in

  已经开发了一种实用的钴催化的芳基氯化物与芳基卤化镁之间的杂联芳基偶合反应，具有空前的选择性。该方案利用了1 mol％的廉价Co（acac）3作为预催化剂，并仅以1.1当量进行了失活的氯苯乙烯的清洁反应。在温和条件下（30°C，5–30分钟）制备格氏试剂。即使在存在活化的溴芳烃的情况下，也实现了高度的化学选择性反应。烯烃取代基通过与催化剂配位促进了C–Cl键的活化。动力学研究表明芳基钴酸酯（I）催化剂种类的操作。在钴（III），（I）和（− I）预催化剂。
• Chlorostyrenes in Iron-Catalyzed Biaryl Coupling Reactions
  作者：Samet Gülak、Axel Jacobi von Wangelin

  DOI：10.1002/anie.201106110

  日期：2012.2.6

  An effective protocol for iron‐catalyzed biaryl syntheses by coupling chlorostyrenes with aryl Grignard reagents requires only mild reaction conditions and tolerates various functional groups. The underlying activation of deactivated aryl chlorides proceeds through a rate‐determining coordination of the catalyst to the vinyl substituent and subsequent haptotropic migration along the conjugated π system

  通过将氯代苯乙烯与芳基格氏试剂偶联来进行铁催化联芳基合成的有效方案只需要温和的反应条件，并能耐受各种官能团。失活的芳基氯化物收益通过催化剂与乙烯基取代基和随后haptotropic迁移沿着共轭π体系，C的部位的速度决定协调底层活化 Cl键裂解。
• COMPOSITE NANOGRANULES FROM POLYMER/INORGANIC NANOPARTICLES, PREPARATION METHOD THEREOF AND USE OF THE SAME
  申请人：Wuxi Now Materials Corp.

  公开号：EP2431413A1

  公开（公告）日：2012-03-21

  Composite nanogranules from polymer/inorganic nanoparticle, especially first composite nanogranules which are formed from first polymer and inorganic nanoparticles, second composite nanogranules which are obtained by forming second polymer on the first composite nanogranules, third composite nanogranules which is obtained by forming third polymer on the second composite nanogranules, and Nth composite nanogranules which is obtained by forming Nth polymer on the (N-1)th composite nanogranules with the similar method, are disclosed. A composition comprising anyone of the composite nanogranules described above is disclosed. The preparation method thereof and use of the same are also disclosed.

  本发明公开了由聚合物/无机纳米颗粒组成的复合纳米颗粒，特别是由第一种聚合物和无机纳米颗粒组成的第一种复合纳米颗粒、在第一种复合纳米颗粒上形成第二种聚合物而得到的第二种复合纳米颗粒、在第二种复合纳米颗粒上形成第三种聚合物而得到的第三种复合纳米颗粒，以及用类似方法在第(N-1)种复合纳米颗粒上形成第N种聚合物而得到的第N种复合纳米颗粒。本发明公开了一种包含上述任何一种复合纳米粒的组合物。还公开了其制备方法和用途。
• US9139430B2
  申请人：——

  公开号：US9139430B2

  公开（公告）日：2015-09-22