(4,4-bis(4-chlorophenyl)-1-phenylbutoxy)(tert-butyl)dimethylsilane | 1229597-16-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4,4-bis(4-chlorophenyl)-1-phenylbutoxy)(tert-butyl)dimethylsilane
• 英文别名: [4,4-Bis(4-chlorophenyl)-1-phenylbutoxy]-tert-butyl-dimethylsilane；[4,4-bis(4-chlorophenyl)-1-phenylbutoxy]-tert-butyl-dimethylsilane
• CAS: 1229597-16-3
• 化学式: C₂₈H₃₄Cl₂OSi
• 分子量: 485.569
• InChiKey: ISZCWIGOSHLUFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.67
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  三丁基(4-氯苯基)锡烷 、 4-(tert-butyldimethylsilyloxy)-4-phenylbut-1-ene 在 Pd(Ii-Pr)(OTs)2 、 copper(II) bis(trifluoromethanesulfonate) 、 氧气 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 48.08h， 以46%的产率得到(4,4-bis(4-chlorophenyl)-1-phenylbutoxy)(tert-butyl)dimethylsilane
  参考文献：
  名称：

  Pd^II-Catalyzed Oxidative 1,1-Diarylation of Terminal Olefins

  摘要：

  Evaluation of the scope of a Pd-II-catalyzed oxidative 1,1-diarylation reaction of terminal olefins using aryl stannanes is reported. The reaction is shown to be tolerant of functionality commonly encountered in organic synthesis; however, the reaction outcome was found to be dependent on the nature of the aryl stannane used. A mechanistic rationale for the observation of this influence is provided.

  DOI：

  10.1021/ol1009575

文献信息

• Pd^II-Catalyzed Oxidative 1,1-Diarylation of Terminal Olefins
  作者：Erik W. Werner、Kaveri B. Urkalan、Matthew S. Sigman

  DOI：10.1021/ol1009575

  日期：2010.6.18

  Evaluation of the scope of a Pd-II-catalyzed oxidative 1,1-diarylation reaction of terminal olefins using aryl stannanes is reported. The reaction is shown to be tolerant of functionality commonly encountered in organic synthesis; however, the reaction outcome was found to be dependent on the nature of the aryl stannane used. A mechanistic rationale for the observation of this influence is provided.