N,N'-Bis(2-(2-methoxyphenyl)ethyl)-pyridine-2,5-dicarboxylic acid amide | 117517-33-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N,N'-Bis(2-(2-methoxyphenyl)ethyl)-pyridine-2,5-dicarboxylic acid amide
• 英文别名: 2-N,5-N-bis[2-(2-methoxyphenyl)ethyl]pyridine-2,5-dicarboxamide
• CAS: 117517-33-6
• 化学式: C₂₅H₂₇N₃O₄
• 分子量: 433.507
• InChiKey: IPKDYRSJUOHQGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,5-二吡啶羧酸 、 2-甲氧基苯乙胺 在 碳酸氢钠 作用下， 以 二氯甲烷 为溶剂， 生成 N,N'-Bis(2-(2-methoxyphenyl)ethyl)-pyridine-2,5-dicarboxylic acid amide
  参考文献：
  名称：

  Pyridine-2,4-and -2,5-dicarboxylic acid amides and medicaments based on

  摘要：

  这项发明涉及公式I的吡啶-2,4-和-2,5-二羧酸衍生物##STR1##其中R.sup.1、R.sup.2、R.sup.3、R.sup.4和X具有所给含义，以及制备这些化合物的方法和它们的用途，特别是在影响胶原和类胶原物质的代谢或Cl.sub.q的生物合成的药物中的使用。

  公开号：

  US05037839A1

文献信息

• AROMATIC 1,4-DI-CARBOXYLAMIDES AND THEIR USE
  申请人：Garcia Gabriel

  公开号：US20100204219A1

  公开（公告）日：2010-08-12

  The invention relates to novel compounds of formula (I) wherein X, Y, Z represent independently from one another C or N, n stands for 1, 2, 3, m is 0 or 1, p stands for 0 or an integer from 1 to 6, R 1 , R 2 represent independently from one another hydrogen, a halogen atom, a hydroxyl group, a C 1 -C 3 alkyl group and a C 1 -C 3 alkoxy group, R 3 represents, independently from one another if p is not 0, hydrogen, halogen, a C 1 -C 5 linear or branched alkyl, a carboxylyl, a carbomethoxyl, carboethoxyl, a benzyl, an acyl, a hydroxyl, a C 1 -C 4 linear or branched alkoxyl, a trifluoromethyl, a cyano, a morpholino, a 1,3-dioxolyl, an N-acetylamidyl or an amidoyl group, a saturated 5-8 membered ring, a heterocyclic ring, optionally substituted by a C 1 -C 3 alkyl, a hydroxyl or a benzyl group, a C 1 -C 6 alkylsulfonyl, a mono or disubstituted C 1 -C 5 alkyl group, a branched or a cyclic amine, R 6 is H or part of a alicyclic, heteroalicyclic ring system, if m is 0 then C represents CF 3 or a branched or unbranched C 1 -C 4 alkyl group, if m=1 then C represents —CH 2 —O—, —CH 2 —, —CH 2 CH 2 —, —CH 2 CH 2 CH 2 —, —CH 2 (CH 2 )CH 2 — or denotes a chemical bond between N—C or C—C, the CONR 6 group may be linked to C either via its carbon or via its nitrogen atom, CYC stands for a by R 3 substituted or unsubstituted phenyl, pyridinyl, naphthyl, quinolinyl, isoquinolinyl, isoxaxolinyl, thiophenyl, 1,3,4 -thiadiazazolidinyl, furanyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, morpholinyl, furanyl, cyclohexenyl, and chromen-2-on-yl and its use as a medicament for the treatment of cancer.
• US5037839A
  申请人：——

  公开号：US5037839A

  公开（公告）日：1991-08-06
• US5512586A
  申请人：——

  公开号：US5512586A

  公开（公告）日：1996-04-30
• US5672614A
  申请人：——

  公开号：US5672614A

  公开（公告）日：1997-09-30
• Pyridine-2,4-and -2,5-dicarboxylic acid amides and medicaments based on
  申请人：Hoechst Aktiengesellschaft

  公开号：US05037839A1

  公开（公告）日：1991-08-06

  The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagne-like substances or the biosynthesis of Cl.sub.q.

  这项发明涉及公式I的吡啶-2,4-和-2,5-二羧酸衍生物##STR1##其中R.sup.1、R.sup.2、R.sup.3、R.sup.4和X具有所给含义，以及制备这些化合物的方法和它们的用途，特别是在影响胶原和类胶原物质的代谢或Cl.sub.q的生物合成的药物中的使用。