N,N'-bis(tetrafluoropropionylamino)ethylene | 119403-52-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-bis(tetrafluoropropionylamino)ethylene
• 英文别名: 2,2,3,3-tetrafluoro-N-[2-(2,2,3,3-tetrafluoropropanoylamino)ethyl]propanamide
• CAS: 119403-52-0
• 化学式: C₈H₈F₈N₂O₂
• 分子量: 316.151
• InChiKey: AIZGUOZWTGKICG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  copper bis(methyl-3-hydroxy-4,4,5,5-tetrafluoro-2-pentenoate) 以 氯仿 为溶剂， 反应 24.0h， 以51%的产率得到N,N'-bis(tetrafluoropropionylamino)ethylene
  参考文献：
  名称：

  Interaction of fluorine-containing 1,3-dicarbonyl compounds with polyamines

  摘要：

  In the reaction of fluorinated copper(II) 1,3-diketonates with diethylenetriamine (or triethylenetetramine) in CHCl3, N,N'-bis(1,3-aminovinylketones) are formed in 21-35% yields. Fluorine-containing 1,3-diketones and 1,3-ketoesters, upon interaction with polyamines without solvent, undergo acid cleavage, forming the corresponding amides. The copper(II) 1,3-ketoesterates are readily cleaved in CHCl3 at 25-degrees-C in excess triethylenetetramine or ethylenediamine.

  DOI：

  10.1007/bf00863371

文献信息

• Condensation of fluoroalkyl-containing 1,3-dicarbonyl compounds with ethylenediamine
  作者：V.I. Saloutin、Z.E. Skryabina、Y.V. Burgart

  DOI：10.1016/s0022-1139(00)81181-1

  日期：1992.3

  interaction of fluoroalkylated 1,3-diketones with ethylenediamine hydroperchlorate; similarly, 1,2,3,4-tetrahydro-1,4-diazepine-5-ones have been obtained from fluorinated 1,3-keto esters. Under mild conditions, fluorinated copper(II) 1,3-diketonates, and copper(II) and nickel(II) N,N′-ethylenebis(aminovinyl ketonates) were found to react with ethylenediamine to form fluoroalkyl-containing N,N′-ethylenebis(aminovinyl

  通过氟烷基化的1，3-二酮与乙二胺氢氯酸盐的直接相互作用制备了2，3-二氢-1 H -1，4-二氮杂pine；类似地，已经从氟化的1，3-酮酯获得了1,2,3,4-四氢-1,4-二氮杂-5-酮。在温和的条件下，发现氟化的1,3-二酮铜（II）和N（N）的铜（II）和N'-亚乙基双（氨基乙烯基酮）会与乙二胺反应生​​成含氟烷基的N，N' -亚乙基双（氨基乙烯基酮）和/或2,3-二氢-1 H -1,4-二氮杂s 。
• 2-Acetyl-substituted polyfluorinated ?-keto esters in reaction with amines
  作者：K. I. Pashkevich、V. M. Krokhalev、V. I. Saloutin

  DOI：10.1007/bf00961931

  日期：1988.6
• PASHKEVICH, K. I.;KROXALEV, V. M.;SALOUTIN, V. I., IZV. AN CCCP. CEP. XIM.,(1988) N 6, 1367-1371
  作者：PASHKEVICH, K. I.、KROXALEV, V. M.、SALOUTIN, V. I.

  DOI：——

  日期：——
• Interaction of fluorine-containing 1,3-dicarbonyl compounds with polyamines
  作者：V. I. Saloutin、Z. �. Skryabina、Ya. V. Burgart、S. V. Kiseleva

  DOI：10.1007/bf00863371

  日期：1992.11

  In the reaction of fluorinated copper(II) 1,3-diketonates with diethylenetriamine (or triethylenetetramine) in CHCl3, N,N'-bis(1,3-aminovinylketones) are formed in 21-35% yields. Fluorine-containing 1,3-diketones and 1,3-ketoesters, upon interaction with polyamines without solvent, undergo acid cleavage, forming the corresponding amides. The copper(II) 1,3-ketoesterates are readily cleaved in CHCl3 at 25-degrees-C in excess triethylenetetramine or ethylenediamine.