1-(2-Hydroxyphenylamino)-pyrrol | 55872-37-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-Hydroxyphenylamino)-pyrrol
• 英文别名: 1-(2-Hydroxyphenylamino)pyrrole；2-(Pyrrol-1-ylamino)phenol
• CAS: 55872-37-2
• 化学式: C₁₀H₁₀N₂O
• 分子量: 174.202
• InChiKey: FCOOKTYMYZQRKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(2-benzyloxyphenylamino)pyrrole 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 1-(2-Hydroxyphenylamino)-pyrrol
  参考文献：
  名称：

  Synthesis and antibacterial activity of 1-(arylamino)-1H-pyrroles and 4-(1H-pyrrol-1-ylimino)-2,5-cyclohexadienes

  摘要：

  The syntheses of 1-(arylamino)-1H-pyrroles and 4-(1H-pyrrol-1-ylimino)-2-5-cyclohexadienes are described. Several of these compounds express in vitro antibacterial activity or can be metabolized to show in vitro antibacterial activity, and a few examples have shown efficacy against tuberculosis in mice. One compound, N,N'-(2,5-cyclohexadiene-1,4-diylidene)bis-1H-pyrrol-1-amine, is completely effective at 6.25 mg/kg against Mycobacterium tuberculosis H37Rv.

  DOI：

  10.1021/jm00143a011

文献信息

• JOHNSON, R. E.;SORIA, A. E.;O CONNOR, J. R.;DOBSON, R. A., J. MED. CHEM., 1981, 24, N 11, 1314-1319
  作者：JOHNSON, R. E.、SORIA, A. E.、O CONNOR, J. R.、DOBSON, R. A.

  DOI：——

  日期：——
• US4138405A
  申请人：——

  公开号：US4138405A

  公开（公告）日：1979-02-06
• US4163015A
  申请人：——

  公开号：US4163015A

  公开（公告）日：1979-07-31
• Synthesis and antibacterial activity of 1-(arylamino)-1H-pyrroles and 4-(1H-pyrrol-1-ylimino)-2,5-cyclohexadienes
  作者：Robert E. Johnson、Albert E. Soria、John R. O'Connor、Richard A. Dobson

  DOI：10.1021/jm00143a011

  日期：1981.11

  The syntheses of 1-(arylamino)-1H-pyrroles and 4-(1H-pyrrol-1-ylimino)-2-5-cyclohexadienes are described. Several of these compounds express in vitro antibacterial activity or can be metabolized to show in vitro antibacterial activity, and a few examples have shown efficacy against tuberculosis in mice. One compound, N,N'-(2,5-cyclohexadiene-1,4-diylidene)bis-1H-pyrrol-1-amine, is completely effective at 6.25 mg/kg against Mycobacterium tuberculosis H37Rv.