2-甲氧基-4-丙-2-烯基-苯酚 | 53890-24-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 中文名称: 2-甲氧基-4-丙-2-烯基-苯酚
• 英文名称: 1'-acetoxyeugenol acetate
• 英文别名: [4-(1-acetyloxyprop-2-enyl)-2-methoxyphenyl] acetate
• CAS: 53890-24-7
• 化学式: C₁₄H₁₆O₅
• 分子量: 264.278
• InChiKey: NKRBAUXTIWONOV-UHFFFAOYSA-N

物化性质

• 沸点：
  338.4±42.0 °C(Predicted)
• 密度：
  1.135±0.06 g/cm3(Predicted)
• LogP：
  2.447 (est)
• 保留指数：
  1799.9

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  香草醛 在 4-二甲氨基吡啶 、 碘 、 magnesium 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 2-甲氧基-4-丙-2-烯基-苯酚
  参考文献：
  名称：

  Anti-proliferative, apoptotic induction, and anti-migration effects of hemi-synthetic 1&prime;<em>S</em>-1&prime;-acetoxychavicol acetate analogs on MDA-MB-231 breast cancer cells

  摘要：

  Nine analogs of 1' S-1'-acetoxychavicol acetate (ACA) were hemi-synthesized and evaluated for their anticancer activities against seven human cancer cell lines. The aim of this study was to investigate the anti-proliferative, apoptotic, and anti-migration effects of these compounds and to explore the plausible underlying mechanisms of action. We found that ACA and all nine analogs were non toxic to human mammary epithelial cells (HMECs) used as normal control cells, and only ACA, 1'-acetoxyeugenol acetate (AEA), and 1'-acetoxy-3,5-dimethoxychavicol acetate (AMCA) inhibited the growth of MDA-MB-231 breast cancer cells with a half-maximal inhibitory concentration (IC50) value of <30.0 mu M based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay results, and were selected for further investigation. DNA fragmentation assays showed that these three compounds markedly induced apoptosis of MDA-MB-231 cells. Western blot analysis revealed increased expression levels of cleaved PARP, p53, and Bax, while decreased expression levels of Bcl-2 and Bcl-xL were seen after treatment, indicating that apoptosis was induced via the mitochondrial pathway. Moreover, ACA, AEA, and AMCA effectively inhibited the migration of MDA-MB-231 cells. They also downregulated the expression levels of pFAK/FAK and pAkt/Akt via the integrin beta 1-mediated signaling pathway. Collectively, ACA and its hemi-synthetic analogs, AEA and AMCA are seen as potential anticancer agents following their abilities to suppress growth, induce apoptosis, and inhibit migration of breast cancer cells.

  DOI：

  10.2147/dddt.s130349

文献信息

• ZANAROTTI, A., J. ORG. CHEM., 1985, 50, N 7, 941-945
  作者：ZANAROTTI, A.

  DOI：——

  日期：——
• Anti-proliferative, apoptotic induction, and anti-migration effects of hemi-synthetic 1&amp;prime;&lt;em&gt;S&lt;/em&gt;-1&amp;prime;-acetoxychavicol acetate analogs on MDA-MB-231 breast cancer cells
  作者：Su Ki Liew、Mohamad Nurul Azmi、Lionel L.A. In、Khalijah Awang、Noor Hasima Nagoor

  DOI：10.2147/dddt.s130349

  日期：——

  Nine analogs of 1' S-1'-acetoxychavicol acetate (ACA) were hemi-synthesized and evaluated for their anticancer activities against seven human cancer cell lines. The aim of this study was to investigate the anti-proliferative, apoptotic, and anti-migration effects of these compounds and to explore the plausible underlying mechanisms of action. We found that ACA and all nine analogs were non toxic to human mammary epithelial cells (HMECs) used as normal control cells, and only ACA, 1'-acetoxyeugenol acetate (AEA), and 1'-acetoxy-3,5-dimethoxychavicol acetate (AMCA) inhibited the growth of MDA-MB-231 breast cancer cells with a half-maximal inhibitory concentration (IC50) value of <30.0 mu M based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay results, and were selected for further investigation. DNA fragmentation assays showed that these three compounds markedly induced apoptosis of MDA-MB-231 cells. Western blot analysis revealed increased expression levels of cleaved PARP, p53, and Bax, while decreased expression levels of Bcl-2 and Bcl-xL were seen after treatment, indicating that apoptosis was induced via the mitochondrial pathway. Moreover, ACA, AEA, and AMCA effectively inhibited the migration of MDA-MB-231 cells. They also downregulated the expression levels of pFAK/FAK and pAkt/Akt via the integrin beta 1-mediated signaling pathway. Collectively, ACA and its hemi-synthetic analogs, AEA and AMCA are seen as potential anticancer agents following their abilities to suppress growth, induce apoptosis, and inhibit migration of breast cancer cells.