4-[2-[6-[2-(4-Hydroxy-3-methoxyphenyl)ethynyl]pyridin-2-yl]ethynyl]-2-methoxyphenol | 742108-74-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-[2-[6-[2-(4-Hydroxy-3-methoxyphenyl)ethynyl]pyridin-2-yl]ethynyl]-2-methoxyphenol
• CAS: 742108-74-3
• 化学式: C₂₃H₁₇NO₄
• 分子量: 371.392
• InChiKey: XJSUFQKRSYHYPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  71.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-[2-[6-[2-(4-Hydroxy-3-methoxyphenyl)ethynyl]pyridin-2-yl]ethynyl]-2-methoxyphenol 在 palladium on activated charcoal 氢气 作用下， 以 乙醚 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of symmetrical bis-alkynyl or alkyl pyridine and thiophene derivatives and their antiangiogenic activities

  摘要：

  Fourteen symmetrical bis-alkynyl pyridine and thiophene derivatives were synthesized and their antiangiogenic activity was evaluated with the proliferation and tube formation inhibitory activity on the human umbilical vein endothelial cells (HUVEC). Compounds 6, 8, and 10, rigid mimetic structure of curcumin, showed the potent growth inhibitory activity and the potent tube formation inhibitory activity. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.065
• 作为产物：
  描述：

  4-(2,2-dibromovinyl)-2-methoxyphenol 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 正丁基锂 、 二乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 生成 4-[2-[6-[2-(4-Hydroxy-3-methoxyphenyl)ethynyl]pyridin-2-yl]ethynyl]-2-methoxyphenol
  参考文献：
  名称：

  Synthesis of symmetrical bis-alkynyl or alkyl pyridine and thiophene derivatives and their antiangiogenic activities

  摘要：

  Fourteen symmetrical bis-alkynyl pyridine and thiophene derivatives were synthesized and their antiangiogenic activity was evaluated with the proliferation and tube formation inhibitory activity on the human umbilical vein endothelial cells (HUVEC). Compounds 6, 8, and 10, rigid mimetic structure of curcumin, showed the potent growth inhibitory activity and the potent tube formation inhibitory activity. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.065

文献信息

• Synthesis of symmetrical bis-alkynyl or alkyl pyridine and thiophene derivatives and their antiangiogenic activities
  作者：Chan Mug Ahn、Woon-Seob Shin、Ho Bum Woo、Seokjoon Lee、Hyean-Woo Lee

  DOI：10.1016/j.bmcl.2004.05.065

  日期：2004.8

  Fourteen symmetrical bis-alkynyl pyridine and thiophene derivatives were synthesized and their antiangiogenic activity was evaluated with the proliferation and tube formation inhibitory activity on the human umbilical vein endothelial cells (HUVEC). Compounds 6, 8, and 10, rigid mimetic structure of curcumin, showed the potent growth inhibitory activity and the potent tube formation inhibitory activity. (C) 2004 Elsevier Ltd. All rights reserved.