nicotinic acid N-(3,5-dinitro-benzoyl)-N'-(4-methoxybenzylidene)-hydrazide | 1261627-53-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: nicotinic acid N-(3,5-dinitro-benzoyl)-N'-(4-methoxybenzylidene)-hydrazide
• 英文别名: N-(3,5-dinitrobenzoyl)-N-[(4-methoxyphenyl)methylideneamino]pyridine-3-carboxamide
• CAS: 1261627-53-5
• 化学式: C₂₁H₁₅N₅O₇
• 分子量: 449.379
• InChiKey: DVNQEUCPQGLTMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.22
• 重原子数：
  33.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  158.14
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  烟酰氯 、 3,5-dinitrobenzoic acid p-methoxybenzyilidene hydrazide 以 乙醚 为溶剂， 反应 24.0h， 以20.6%的产率得到nicotinic acid N-(3,5-dinitro-benzoyl)-N'-(4-methoxybenzylidene)-hydrazide
  参考文献：
  名称：

  Synthesis and antitubercular activities of substituted benzoic acid N′-(substituted benzylidene/furan-2-ylmethylene)-N-(pyridine-3-carbonyl)-hydrazides

  摘要：

  A series of benzoic acid hydrazones and its nicotinyl derivatives (1-10) were prepared and evaluated for their antitubercular activity towards a strain of Mycobacterium tuberculosis (MTB). The structures of newly synthesized compounds were confirmed by infrared (IR) and H-1-nuclear magnetic resonance (NMR) spectral data and elemental analysis. The in vitro antitubercular activity of synthesized compounds against MTB was carried out in Middlebrook 7H11agar medium supplemented with OADC by agar dilution method. The antitubercular activity results indicated that nicotinic acid N-(3,5-dinitrobenzoyl)-N'-(4-methoxy-benzylidene)-hydrazide (1) is the most potent among the synthesized compounds with MIC of 3.5 x 10(-3) mu M. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.08.030

文献信息

• Synthesis and antitubercular activities of substituted benzoic acid N′-(substituted benzylidene/furan-2-ylmethylene)-N-(pyridine-3-carbonyl)-hydrazides
  作者：Pradeep Kumar、Balasubramanian Narasimhan、Perumal Yogeeswari、Dharmarajan Sriram

  DOI：10.1016/j.ejmech.2010.08.030

  日期：2010.12

  A series of benzoic acid hydrazones and its nicotinyl derivatives (1-10) were prepared and evaluated for their antitubercular activity towards a strain of Mycobacterium tuberculosis (MTB). The structures of newly synthesized compounds were confirmed by infrared (IR) and H-1-nuclear magnetic resonance (NMR) spectral data and elemental analysis. The in vitro antitubercular activity of synthesized compounds against MTB was carried out in Middlebrook 7H11agar medium supplemented with OADC by agar dilution method. The antitubercular activity results indicated that nicotinic acid N-(3,5-dinitrobenzoyl)-N'-(4-methoxy-benzylidene)-hydrazide (1) is the most potent among the synthesized compounds with MIC of 3.5 x 10(-3) mu M. (C) 2010 Elsevier Masson SAS. All rights reserved.