4-chloro-N-[(4-methoxyphenyl)methylideneamino]benzamide | 51771-28-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-N-[(4-methoxyphenyl)methylideneamino]benzamide
• CAS: 51771-28-9
• 化学式: C₁₅H₁₃ClN₂O₂
• mdl: MFCD00779652
• 分子量: 288.733
• InChiKey: LKVQAJOKAKNCOO-UHFFFAOYSA-N

物化性质

• 熔点：
  174 °C
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  4-chloro-N-[(4-methoxyphenyl)methylideneamino]benzamide 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以87%的产率得到2-(4-chlorophenyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole
  参考文献：
  名称：

  Convenient preparation of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles promoted by Dess–Martin reagent

  摘要：

  2,5-Disubstituted 1,3,4-oxadiazoles have been conveniently prepared by oxidative cyclization of N-acyl-N'-aryliden-hydrazines promoted by all excess or Dess-Martin periodinane under Mild conditions (23 examples, up to 92% isolated yields). (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.02.054
• 作为产物：
  描述：

  4-甲氧基苯甲醛 、 4-氯苯甲酰肼 以 乙醇 为溶剂， 生成 4-chloro-N-[(4-methoxyphenyl)methylideneamino]benzamide
  参考文献：
  名称：

  Dave; Patel; Langalia, Journal of the Indian Chemical Society, 1984, vol. 61, # 10, p. 891 - 892

  摘要：

  DOI：

文献信息

• Dave; Patel; Langalia, Journal of the Indian Chemical Society, 1984, vol. 61, # 10, p. 891 - 892
  作者：Dave、Patel、Langalia、Thaker

  DOI：——

  日期：——
• Synthesis and antitubercular activities of substituted benzoic acid N′-(substituted benzylidene/furan-2-ylmethylene)-N-(pyridine-3-carbonyl)-hydrazides
  作者：Pradeep Kumar、Balasubramanian Narasimhan、Perumal Yogeeswari、Dharmarajan Sriram

  DOI：10.1016/j.ejmech.2010.08.030

  日期：2010.12

  A series of benzoic acid hydrazones and its nicotinyl derivatives (1-10) were prepared and evaluated for their antitubercular activity towards a strain of Mycobacterium tuberculosis (MTB). The structures of newly synthesized compounds were confirmed by infrared (IR) and H-1-nuclear magnetic resonance (NMR) spectral data and elemental analysis. The in vitro antitubercular activity of synthesized compounds against MTB was carried out in Middlebrook 7H11agar medium supplemented with OADC by agar dilution method. The antitubercular activity results indicated that nicotinic acid N-(3,5-dinitrobenzoyl)-N'-(4-methoxy-benzylidene)-hydrazide (1) is the most potent among the synthesized compounds with MIC of 3.5 x 10(-3) mu M. (C) 2010 Elsevier Masson SAS. All rights reserved.
• Convenient preparation of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles promoted by Dess–Martin reagent
  作者：Cristian Dobrotă、Codruţa C. Paraschivescu、Ioana Dumitru、Mihaela Matache、Ion Baciu、Lavinia L. Ruţă

  DOI：10.1016/j.tetlet.2009.02.054

  日期：2009.4

  2,5-Disubstituted 1,3,4-oxadiazoles have been conveniently prepared by oxidative cyclization of N-acyl-N'-aryliden-hydrazines promoted by all excess or Dess-Martin periodinane under Mild conditions (23 examples, up to 92% isolated yields). (C) 2009 Elsevier Ltd. All rights reserved.