6-amino-5-(3,4-dihydroxy-5-methylphenyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione | 1009599-01-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-amino-5-(3,4-dihydroxy-5-methylphenyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
• 英文别名: 6-Amino-5-(3,4-dihydroxy-5-methylphenyl)-1,3-dimethylpyrimidine-2,4-dione
• CAS: 1009599-01-2
• 化学式: C₁₃H₁₅N₃O₄
• 分子量: 277.28
• InChiKey: YAOCVBSUYCBGEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,3-二甲基-6-氨基脲嘧啶 、 3-甲基苯邻二酚 在 sodium acetate 作用下， 以 水 为溶剂， 以94%的产率得到6-amino-5-(3,4-dihydroxy-5-methylphenyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
  参考文献：
  名称：

  Electrochemical synthesis of 6-amino-5-(3,4-dihydroxyphenyl) pyrimidine

  摘要：

  Electrochemical oxidation of several catechols is studied in the presence of 4(6)-aminouracil (3a) and 6-amino-1,3-dimethyl uracil (3b) as nucleophiles in aqueous solution using cyclic voltammetry and controlled-potential coulometry. The results reveal that quinones derived from catechols participate in Michael additions with 3a and 3b to give the corresponding catecholamine derivatives via an electron transfer followed by chemical reaction (EC) mechanistic pathway in good yields and purities. (c) 2007 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2007.11.134

文献信息

• Electrochemical synthesis of 6-amino-5-(3,4-dihydroxyphenyl) pyrimidine
  作者：Saied Saeed Hosseiny Davarani、Neda Sheijooni Fumani、Hamid Arvin-Nezhad、Farzaneh Moradi

  DOI：10.1016/j.tetlet.2007.11.134

  日期：2008.1

  Electrochemical oxidation of several catechols is studied in the presence of 4(6)-aminouracil (3a) and 6-amino-1,3-dimethyl uracil (3b) as nucleophiles in aqueous solution using cyclic voltammetry and controlled-potential coulometry. The results reveal that quinones derived from catechols participate in Michael additions with 3a and 3b to give the corresponding catecholamine derivatives via an electron transfer followed by chemical reaction (EC) mechanistic pathway in good yields and purities. (c) 2007 Published by Elsevier Ltd.