1,3-dimethyl-6-(phenylsulfonyl)-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-2,4-dione | 1365647-86-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 1,3-dimethyl-6-(phenylsulfonyl)-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-2,4-dione
• 英文别名: 6-(Benzenesulfonyl)-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione；6-(benzenesulfonyl)-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione
• CAS: 1365647-86-4
• 化学式: C₁₅H₁₃N₃O₄S
• 分子量: 331.352
• InChiKey: QDRRFFGJJBBYOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  96
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,3-二甲基-6-氨基脲嘧啶 、 2-(phenylsulfonyl)-1,1,5,5-tetramethyl-1,5-diazapentadienium perchlorate 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以73%的产率得到1,3-dimethyl-6-(phenylsulfonyl)-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-2,4-dione
  参考文献：
  名称：

  Efficient One-Pot Synthesis of Substituted Pyrido[2,3-d]pyrimidines from Vinamidinium and Chloropropeniminium Salts

  摘要：

  A novel and efficient one-pot preparation of 6-substituted pyrido-[2,3-d]pyrimidines by cyclocondensation of 6-amino-1,3-dimethyluracil with symmetrical vinamidinium salts under basic conditions has been developed. Regioselectivity was observed with an unsymmetrical chloropropeniminium salt.

  DOI：

  10.1080/00397911.2010.545163

文献信息

• Efficient One-Pot Synthesis of Substituted Pyrido[2,3-d]pyrimidines from Vinamidinium and Chloropropeniminium Salts
  作者：Mohamed Adnen Hadj Ayed、Thouraya Gmiza、Jamel Eddine Khiari、Béchir Ben Hassine

  DOI：10.1080/00397911.2010.545163

  日期：2012.6.15

  A novel and efficient one-pot preparation of 6-substituted pyrido-[2,3-d]pyrimidines by cyclocondensation of 6-amino-1,3-dimethyluracil with symmetrical vinamidinium salts under basic conditions has been developed. Regioselectivity was observed with an unsymmetrical chloropropeniminium salt.