The photooxygenation of 2-propargylfurans enabled access to original nitrogen-containing cyclopentenones and related compounds in a one-pot fashion. By employing readily-available substrates such as furans and amines, we succeeded in achieving a high degree of molecular complexity. Relying on the introduction of an alkyne moiety and tailored substrates, this transformation reveals a new facet for reaction
Lewis Acid Catalyzed Propargylation of Arenes with <i>O</i>-Propargyl Trichloroacetimidates: Synthesis of 1,3-Diarylpropynes
作者:Changkun Li、Jianbo Wang
DOI:10.1021/jo0709192
日期:2007.9.1
[GRAPHICS]The BF3 center dot OEt2-catalyzed Friedel-Crafts propargylation of aromatic compounds with O-propargyl trichloroacetimidates is highly efficient and affords 1,3-diarylpropyne derivatives in good yields.