5-benzyl-1-butyl-3,5-dihydroxy-4-phenyl-1H-pyrrol-2(5H)-one | 1187670-37-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-benzyl-1-butyl-3,5-dihydroxy-4-phenyl-1H-pyrrol-2(5H)-one
• 英文别名: 5-Benzyl-1-butyl-3,5-dihydroxy-4-phenylpyrrol-2-one
• CAS: 1187670-37-6
• 化学式: C₂₁H₂₃NO₃
• 分子量: 337.419
• InChiKey: GQPCEPOOVPKZQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (Z)-3-(butylamino)-3-oxo-1-phenylprop-1-en-2-yl 2-phenylacetate 在 sodium t-butanolate 作用下， 以 叔丁醇 为溶剂， 反应 0.08h， 以84%的产率得到5-benzyl-1-butyl-3,5-dihydroxy-4-phenyl-1H-pyrrol-2(5H)-one
  参考文献：
  名称：

  Isocyanides and Arylacetic Acids: Synthesis and Reactivity of 3-Aryl-2-acyloxyacrylamides, an Example of Serendipity-Oriented Synthesis

  摘要：

  Research progress is often promoted by unexpected results that open the way to new scenarios. In this communication, an unprecedented condensation of arylacetic acids and isocyanides and the unusual base-mediated rearrangement of the resulting products to give two novel classes of polysubstituted pyrrolones and pyrrolidinediones are reported.

  DOI：

  10.1021/ol901512c

文献信息

• Isocyanides and Arylacetic Acids: Synthesis and Reactivity of 3-Aryl-2-acyloxyacrylamides, an Example of Serendipity-Oriented Synthesis
  作者：Andrea Basso、Luca Banfi、Andrea Galatini、Giuseppe Guanti、Federico Rastrelli、Renata Riva

  DOI：10.1021/ol901512c

  日期：2009.9.17

  Research progress is often promoted by unexpected results that open the way to new scenarios. In this communication, an unprecedented condensation of arylacetic acids and isocyanides and the unusual base-mediated rearrangement of the resulting products to give two novel classes of polysubstituted pyrrolones and pyrrolidinediones are reported.