4-methyl-N-(1-phenyl-2-(quinolin-2-yl)propyl)benzenesulfonamide | 1218989-10-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-(1-phenyl-2-(quinolin-2-yl)propyl)benzenesulfonamide
• 英文别名: 4-methyl-N-(1-phenyl-2-quinolin-2-ylpropyl)benzenesulfonamide
• CAS: 1218989-10-6
• 化学式: C₂₅H₂₄N₂O₂S
• 分子量: 416.544
• InChiKey: LPUNFSPCBMFSKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯甲醛 在 硅酸四乙酯 作用下， 以 甲苯 为溶剂， 反应 24.0h， 生成 4-methyl-N-(1-phenyl-2-(quinolin-2-yl)propyl)benzenesulfonamide
  参考文献：
  名称：

  A Catalyst-Free Benzylic C–H Bond Olefination of Azaarenes for Direct Mannich-like Reactions

  摘要：

  A highly efficient synthesis of trans-alkenylazaarene under catalyst-free conditions was developed via the addition of methylazaarenes to N-sulfonyl aldimines and a subsequent C-N elimination in situ. A one-pot procedure for this addition-elimination was also developed. The reaction could tolerate a broad substrate scope and give the corresponding alkenylazaarenes in high yields.

  DOI：

  10.1021/jo2008934

文献信息

• Palladium-Catalyzed Benzylic Addition of 2-Methyl Azaarenes to <i>N</i>-Sulfonyl Aldimines via C−H Bond Activation
  作者：Bo Qian、Shengmei Guo、Jianping Shao、Qiming Zhu、Lei Yang、Chungu Xia、Hanmin Huang

  DOI：10.1021/ja910104n

  日期：2010.3.24

  generation of amines by palladium-catalyzed nucleophilic benzylic addition of 2-methyl-substituted azaarenes to N-sulfonyl aldimines under neutral conditions via C-H bond activation has been developed. This reaction represents a very efficient methodology for the synthesis of heterocycle-containing amines and thus opens a new way to access amines through C-H bond activation.

  已开发出一种通过在中性条件下通过 CH 键活化将 2-甲基取代的氮杂芳烃与 N-磺酰基醛亚胺进行钯催化的亲核苄基加成生成胺的有效方案。该反应代表了一种非常有效的合成含杂环胺的方法，因此开辟了一种通过 CH 键活化获得胺的新方法。
• A Catalyst-Free Benzylic C–H Bond Olefination of Azaarenes for Direct Mannich-like Reactions
  作者：Yizhe Yan、Kun Xu、Yang Fang、Zhiyong Wang

  DOI：10.1021/jo2008934

  日期：2011.8.19

  A highly efficient synthesis of trans-alkenylazaarene under catalyst-free conditions was developed via the addition of methylazaarenes to N-sulfonyl aldimines and a subsequent C-N elimination in situ. A one-pot procedure for this addition-elimination was also developed. The reaction could tolerate a broad substrate scope and give the corresponding alkenylazaarenes in high yields.