N-n-eicosylpyridinium bromide | 134782-13-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-n-eicosylpyridinium bromide
• 英文别名: eicosadecylpyridinium bromide；N-eicosylpyridinium bromide；1-Icosylpyridinium bromide；1-icosylpyridin-1-ium;bromide
• CAS: 134782-13-1
• 化学式: Br*C₂₅H₄₆N
• 分子量: 440.551
• InChiKey: HXFRZGDWHWJPAF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  5.02
• 重原子数：
  27
• 可旋转键数：
  19
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  potassium tetrachloroplatinate(II) 、 (tetramethylammonium)4Ge4S10 、 N-n-eicosylpyridinium bromide 以 formamide 为溶剂， 以80%的产率得到
  参考文献：
  名称：

  铂硫属元素 MCM-41 类似物。基于 Pt2+ 和 [Ge4Q10]4-(Q = S, Se) 和 [Sn4Se10]4-金刚烷团簇的介孔结构半导体中的高六方有序

  摘要：

  通过连接相应的 [Ge(4)Q(10)](4)(-) (Q = S, Se) 和 [Sn(4)Se (10)](4)(-) 簇与 Pt(2+) 离子。命名为 C(n)PyPtGeQ 和 C(n)PyPtSnSe 的非氧化蜂窝由烷基吡啶表面活性剂 [C(n)H(2)(n)(+1)NC(5) 的溶致液晶相模板化H(5)]Br (C(n)PyBr)，n = 12、14、16、18、20 和 22。尽管这些材料在微观尺度上是无定形的，但它们具有结晶中孔率和有序排列的表面活性剂-填充圆柱孔。除了高介观有序性外，孔-孔分离还可以通过表面活性剂链长（即 n 值）进行调节。这些材料的质量，以六边形排列的程度来判断，与报告的最高质量 MCM-41 硅酸盐相媲美或超过。迄今为止，对于介观结构硫属化物固体，这些材料具有最低的带隙，范围为 1.5 < E(g) < 2.3 eV。当用带隙以上的光激发时，C(n)PyPtGeS

  DOI：

  10.1021/ja017245b
• 作为产物：
  描述：

  吡啶 、 溴代二十烷 以 乙醇 为溶剂， 反应 40.0h， 以79%的产率得到N-n-eicosylpyridinium bromide
  参考文献：
  名称：

  N-烷基取代基长度不同的吡啶鎓盐的制备。

  摘要：

  链为 C8 至 C20 的季吡啶盐属于一大类阳离子表面活性剂。在本文中，描述了这种基于吡啶鎓部分和不同N-烷基链长度的阳离子表面活性剂的制备。此外，建立了 HPLC 技术来区分每种制备的吡啶类似物。本研究代表了制备和鉴定季吡啶类洗涤剂的通用方法。

  DOI：

  10.3390/molecules15031967

文献信息

• Importance of Solution Equilibria in the Directed Assembly of Metal Chalcogenide Mesostructures
  作者：Santanu Bag、Mercouri G. Kanatzidis

  DOI：10.1021/ja800741h

  日期：2008.7.1

  spectroscopy and it is shown that rapid exchange equilibrium is reached between species like [Ge4Se10](4-), [Ge2Se6](4-), and [GeSe4](4-) in both water and formamide. This results in multiple Ge/Se anions being incorporated in the mesostructured materials which is supported by Raman and IR spectroscopic data. It is likely that the presence of multiple building units both in water and formamide solutions favors

  我们描述了由分子单元 [Ge2Se6](4-) 和 [GeSe4](4-) 制备的新型纳米结构 Pt/Ge/Se 材料，并在表面活性剂胶束的存在下连接 Pt(2+) 离子。X 射线衍射结合透射电子显微镜图像揭示了六角孔的对称性。通过多核 NMR 光谱和快速原子轰击 (FAB) 质谱研究了这些构件的溶剂依赖性和溶液形态，结果表明 [Ge4Se10](4-)、[Ge4Se10](4-)、[ Ge2Se6](4-) 和 [GeSe4](4-) 在水和甲酰胺中。这导致多个 Ge/Se 阴离子被结合到细观结构材料中，这得到了拉曼和红外光谱数据的支持。水和甲酰胺溶液中存在多种结构单元可能有利于具有良好孔序的介孔结构金属硫属元素化物的组装。表面活性剂头基和链长的系统变化调节介观结构的光电特性。Pt/Ge/Se 材料在 1.24-1.97 eV 范围内显示出尖锐的带隙跃迁。最后，这些材料表现出可逆的离子交
• MODIFIED AMADORIASE AND METHOD FOR PRODUCING SAME, AGENT FOR IMPROVING SURFACTANT-RESISTANCE OF AMADORIASE AND COMPOSITION FOR MEASURING HbA1c USING SAME
  申请人：Kikkoman Corporation

  公开号：EP3031914A1

  公开（公告）日：2016-06-15

  Provided is a composition by which glycated hemoglobin can be measured even in the presence of a stronger surfactant than a conventional case. Also provided is a buffer and/or stabilizer which maintains the residual activity of an amadoriase or lowers a reduction of residual activity. The present invention provides a composition for use in measuring glycated hemoglobin containing an amadoriase having substitution of one or more amino acid residues at a position(s) corresponding to an amino acid(s) selected from the group consisting of position 262, position 257, position 249, position 253, position 337, position 340, position 232, position 129, position 132, position 133, position 44, position 256, position 231 and position 81 of an amadoriase derived from the genus Coniochaeta and represented by SEQ ID No: 1 or 3, and having residual activity even in the presence of a surfactant. The present invention also provides a composition and kit for use in measuring glycated hemoglobin, comprising a specific stabilizer and/or a buffer. The present invention can provide an enzyme and a composition for use in measuring glycated hemoglobin, excellent in storage stability even if they are exposed to a surfactant.

  本发明提供了一种即使在表面活性剂强于常规情况下也能测定糖化血红蛋白的组合物。本发明还提供了一种缓冲剂和/或稳定剂，可保持氨甲蝶呤酶的残余活性或降低残余活性的降低。本发明提供了一种用于测定糖化血红蛋白的组合物，该组合物含有在与选自 Coniochaeta 属并由 SEQ ID No：1 或 3 所代表的氨甲蝶呤酶，即使在表面活性剂存在的情况下也具有残余活性。本发明还提供了一种用于测量糖化血红蛋白的组合物和试剂盒，其中包含一种特定的稳定剂和/或缓冲剂。本发明可提供一种酶和一种用于测量糖化血红蛋白的组合物，即使它们暴露于表面活性剂中，也具有极佳的储存稳定性。
• AMADORIASE HAVING IMPROVED SPECIFIC ACTIVITY
  申请人：Kikkoman Corporation

  公开号：EP3279323A1

  公开（公告）日：2018-02-07

  This invention provides an amadoriase having improved specific activity on a glycated substrate, compared with conventional amadoriase. Provided is an amadoriase comprising a substitution of the amino acid at the position corresponding to position 64 of the amino acid sequence as shown in SEQ ID NO: 1 with an amino acid selected from the group consisting of glycine, serine, methionine, leucine, threonine, valine, and isoleucine, a method for measurement of HbAlc, and a reagent kit for measurement of HbAlc using such amadoriase. Such method and kit for measurement enable rapid, simple, and accurate quantification of HbAlc.

  本发明提供了一种氨甲蝶呤酶，与传统的氨甲蝶呤酶相比，该酶对糖化底物的特异性活性有所提高。本发明提供了一种氨甲蝶呤酶，其包含用一种选自由甘氨酸、丝氨酸、蛋氨酸、亮氨酸、苏氨酸、缬氨酸和异亮氨酸组成的组中的氨基酸取代与 SEQ ID NO: 1 所示氨基酸序列的第 64 位相对应的位置上的氨基酸；一种测定 HbAlc 的方法；以及一种使用这种氨甲蝶呤酶测定 HbAlc 的试剂盒。这种测量方法和试剂盒可快速、简单、准确地定量测定 HbAlc。
• AMADORIASE AND METHOD FOR PRODUCING THE SAME, AGENT FOR IMPROVING SURFACTANT RESISTANCE OF AMADORIASE AND COMPOSITION FOR MEASURING HBA1C USING THE SAME
  申请人：Kikkoman Corporation

  公开号：EP3760717A1

  公开（公告）日：2021-01-06

  Provided is a composition by which glycated hemoglobin can be measured even in the presence of a stronger surfactant than a conventional case. Also provided is a buffer and/or stabilizer which maintains the residual activity of an amadoriase or lowers a reduction of residual activity. The present invention provides a composition for use in measuring glycated hemoglobin containing an amadoriase having substitution of one or more amino acid residues at a position(s) corresponding to an amino acid(s) selected from the group consisting of position 262, position 257, position 249, position 253, position 337, position 340, position 232, position 129, position 132, position 133, position 44, position 256, position 231 and position 81 of an amadoriase derived from the genus Coniochaeta and represented by SEQ ID No: 1 or 3, and having residual activity even in the presence of a surfactant. The present invention also provides a composition and kit for use in measuring glycated hemoglobin, comprising a specific stabilizer and/or a buffer. The present invention can provide an enzyme and a composition for use in measuring glycated hemoglobin, excellent in storage stability even if they are exposed to a surfactant.

  本发明提供了一种即使在表面活性剂强于常规情况下也能测定糖化血红蛋白的组合物。本发明还提供了一种缓冲剂和/或稳定剂，可保持氨甲蝶呤酶的残余活性或降低残余活性的降低。本发明提供了一种用于测定糖化血红蛋白的组合物，该组合物含有在与选自 Coniochaeta 属并由 SEQ ID No：1 或 3 所代表的氨甲蝶呤酶，即使在表面活性剂存在的情况下也具有残余活性。本发明还提供了一种用于测量糖化血红蛋白的组合物和试剂盒，其中包含一种特定的稳定剂和/或缓冲剂。本发明可提供一种酶和一种用于测量糖化血红蛋白的组合物，即使它们暴露于表面活性剂中，也具有极佳的储存稳定性。
• Modified amadoriase and method for producing the same, agent for improving surfactant resistance of amadoriase and composition for measuring HbA1c using the same
  申请人：Kikkoman Corporation

  公开号：US10619183B2

  公开（公告）日：2020-04-14

  Provided is a composition by which glycated hemoglobin can be measured even in the presence of a stronger surfactant than a conventional case. Also provided is a buffer and/or stabilizer which maintains the residual activity of an amadoriase or lowers a reduction of residual activity. The present invention provides a composition for use in measuring glycated hemoglobin containing an amadoriase having substitution of one or more amino acid residues at a position(s) corresponding to an amino acid(s) selected from the group consisting of position 262, position 257, position 249, position 253, position 337, position 340, position 232, position 129, position 132, position 133, position 44, position 256, position 231 and position 81 of an amadoriase derived from the genus Coniochaeta and represented by SEQ ID No: 1 or 3, and having residual activity even in the presence of a surfactant. The present invention also provides a composition and kit for use in measuring glycated hemoglobin, comprising a specific stabilizer and/or a buffer. The present invention can provide an enzyme and a composition for use in measuring glycated hemoglobin, excellent in storage stability even if they are exposed to a surfactant.

  本发明提供了一种即使在表面活性剂强于常规情况下也能测定糖化血红蛋白的组合物。本发明还提供了一种缓冲剂和/或稳定剂，可保持氨甲蝶呤酶的残余活性或降低残余活性的降低。本发明提供了一种用于测定糖化血红蛋白的组合物，该组合物含有在与选自 Coniochaeta 属并由 SEQ ID No：1 或 3 所代表的氨甲蝶呤酶，即使在表面活性剂存在的情况下也具有残余活性。本发明还提供了一种用于测量糖化血红蛋白的组合物和试剂盒，其中包含一种特定的稳定剂和/或缓冲剂。本发明可提供一种酶和一种用于测量糖化血红蛋白的组合物，即使它们暴露于表面活性剂中，也具有极佳的储存稳定性。