(Z)-3-(4-methoxyphenyl)methylidene-N-(4-methylphenyl)isoindolin-1-one | 1415662-26-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: (Z)-3-(4-methoxyphenyl)methylidene-N-(4-methylphenyl)isoindolin-1-one
• 英文别名: (3Z)-3-[(4-methoxyphenyl)methylidene]-2-(4-methylphenyl)isoindol-1-one
• CAS: 1415662-26-8
• 化学式: C₂₃H₁₉NO₂
• 分子量: 341.409
• InChiKey: DYRRVMBQQAOVCW-JCMHNJIXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-碘-N-(4-甲基苯基)苯甲酰胺 、 4-乙炔基苯甲醚 在 双(乙腈)氯化钯(II) 、 水 、 十六烷基三甲基溴化铵 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 异烟醛 (4-吡啶亚甲基)腙 作用下， 反应 1.0h， 以87%的产率得到(Z)-3-(4-methoxyphenyl)methylidene-N-(4-methylphenyl)isoindolin-1-one
  参考文献：
  名称：

  A novel approach for highly regio- and stereoselective synthesis of (Z)-3-methyleneisoindoline-1-ones in aqueous micellar medium

  摘要：

  An environmentally benign and operationally simple methodology was developed for the regio- and stereoselective synthesis of (Z)-3-methyleneisoindolinones in aqueous micellar medium from 2-iodo-N-phenyl-benzamides and terminal alkyne by Cu-free domino Sonogashira reaction followed by 5-exo-dig-cyclization using Pd(CH3CN)Cl-2 as catalyst and 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene as ligand under aerobic condition. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.10.001

文献信息

• A novel approach for highly regio- and stereoselective synthesis of (Z)-3-methyleneisoindoline-1-ones in aqueous micellar medium
  作者：Swarbhanu Sarkar、Samrat Dutta、Rajdip Dey、Subhendu Naskar

  DOI：10.1016/j.tetlet.2012.10.001

  日期：2012.12

  An environmentally benign and operationally simple methodology was developed for the regio- and stereoselective synthesis of (Z)-3-methyleneisoindolinones in aqueous micellar medium from 2-iodo-N-phenyl-benzamides and terminal alkyne by Cu-free domino Sonogashira reaction followed by 5-exo-dig-cyclization using Pd(CH3CN)Cl-2 as catalyst and 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene as ligand under aerobic condition. (C) 2012 Elsevier Ltd. All rights reserved.