bis-(2-bromomethyl-phenyl) sulfone | 42026-70-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis-(2-bromomethyl-phenyl) sulfone
• 英文别名: 2,2'-sulfonylbis((bromomethyl)benzene)；S,S-Dioxid-bis-(2-brommethylphenyl)-sulfid；Bis-(2-brommethylphenyl)-sulfid-S-dioxid；Bis-(2-brommethyl-phenyl)-sulfon；Bis(2-bromomethylphenyl)sulfon；Bis(bromomethyl-phenyl)-sulfone；1-(bromomethyl)-2-[2-(bromomethyl)phenyl]sulfonylbenzene
• CAS: 42026-70-0
• 化学式: C₁₄H₁₂Br₂O₂S
• 分子量: 404.122
• InChiKey: WNMQZEJCMIEVJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  bis-(2-bromomethyl-phenyl) sulfone 在 氢氧化钾 、 三丁基锑 作用下， 生成 bis(2-methylphenyl) sulfone
  参考文献：
  名称：

  叔丁啶对苯甲酰和苄基溴的脱溴作用及机理考虑

  摘要：

  三丁基士比汀是一种用于苯甲酰基和芳基甲基溴脱溴的有效试剂。简要讨论了锑锭和磷化氢之间的机理差异。

  DOI：

  10.1016/s0040-4039(00)98154-1

文献信息

• BIARYL AND BIHETEROARYL COMPOUNDS USEFUL IN TREATING IRON DISORDERS
  申请人：Chafeev Mikhail

  公开号：US20080234384A1

  公开（公告）日：2008-09-25

  This invention is directed to compounds of formula (I): wherein m, n, R 1 , R 2 and R 3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment of iron disorders. This invention is also directed to pharmaceutical compositions comprising the compounds and methods of using the compounds to treat iron disorders.

  本发明涉及以下式（I）的化合物：其中m、n、R1、R2和R3如本文中所定义，作为立体异构体、对映异构体、互变异构体或其混合物；或其药学上可接受的盐、溶剂化合物或前药，用于治疗铁代谢紊乱。本发明还涉及包含这些化合物的药物组合物以及使用这些化合物治疗铁代谢紊乱的方法。
• Compounds
  申请人：Gore Paul Martin

  公开号：US20090270355A1

  公开（公告）日：2009-10-29

  The present invention relates to a compound which is N-(4-4-[(6-butyl-8-quinolinyl)oxy]-1-piperidinyl}butyl)ethanesulfonamide and salts thereof, processes for its preparation, to compositions containing it and to its use in the treatment of various diseases, such as allergic rhinitis.

  本发明涉及一种化合物，即N-(4-4-[(6-丁基-8-喹啉基)氧基]-1-哌啶基}丁基)乙烷磺酰胺及其盐，以及其制备方法、含有该化合物的组合物，以及在治疗各种疾病（如过敏性鼻炎）中的用途。
• Thiocarbonylthio compound and free radical polymerization employing the same
  申请人：Shih Chen Kuo

  公开号：US20060270867A1

  公开（公告）日：2006-11-30

  A thiocarbonylthio compound and free radical polymerization employing the same. The thiocarbonylthio compound is represented by formula (I) or (II): wherein Z can be independently perfluoroalkyl, alkyl, haloalkyl, aryl, alkylaryl, haloalkylaryl, arylalkyl, aminoalkyl, alkylamino, alkoxy, alkoxyaryl, alkylsulfonyl, alkylsulfonylaryl, dialkylphosphinyl, or dialkylphosphinothioyl; R 1 and R 2 can be each independently hydrogen, alkyl, aryl, alkylaryl, arylalkyl, aminoalkyl, alkylamino, alkoxy or alkoxyaryl; R 3 is alkyl, aryl, aminoalkyl, alkylamino, alkoxy or alkoxyaryl. Furthermore, R can also be alkyl, aryl, alkylaryl, arylalkyl, aminoalkyl, alkylamino, alkoxy, haloalkylaryl, alkylsilyl, alkylthio, alkylthioaryl, or substituent contaning CN, CO, COOH, COOCH 3 or heterocyclic moieties; and R 4 is perfluoroalkyl. The thiocarbonylthio compound can be used as a reversible chain transfer agent in a free radical polymerization to obtain a polymer with a controlled molecular weight and narrow polydispersity.

  一种硫代羰基硫化合物和利用该硫代羰基硫化合物进行自由基聚合的方法。该硫代羰基硫化合物由式(I)或(II)表示：其中Z可以独立地是全氟烷基、烷基、卤代烷基、芳基、烷基芳基、卤代烷基芳基、芳基烷基、氨基烷基、烷基氨基、烷氧基、烷氧基芳基、烷基磺酰基、烷基磺酰基芳基、二烷基膦基或二烷基磷硫酰基；R1和R2可以各自独立地是氢、烷基、芳基、烷基芳基、芳基烷基、氨基烷基、烷基氨基、烷氧基或烷氧基芳基；R3是烷基、芳基、氨基烷基、烷基氨基、烷氧基或烷氧基芳基。此外，R也可以是烷基、芳基、烷基芳基、芳基烷基、氨基烷基、烷基氨基、烷氧基、卤代烷基芳基、烷基硅基、烷基硫基、烷基硫基芳基，或含有CN、CO、COOH、COOCH3或杂环基团的取代基；R4是全氟烷基。该硫代羰基硫化合物可用作自由基聚合中可逆链转移剂，以获得具有受控分子量和窄聚分度的聚合物。
• Studies on Diphenyl Ether Derivatives. VIII. NMR Spectra and Conformational Structure of Dibenz[b, g][1, 5]oxazocine and Thiazocine Derivatives and Their Mass Spectra
  作者：SATORU TANAKA、KAZUNORI HASHIMOTO、HIDEAKI WATANABE、KENYA SAKAGUCHI

  DOI：10.1248/cpb.21.1683

  日期：——

  The NMR spectra of 6-substituted 6, 7-dihydro-5H-dibenz[b, g][1, 5]oxazocine and thiazocine derivatives (1) and the sulfoxides or sulfones (6) and the bimolecular sixteen membered ring compounds (2) were reported. The methylene protons at 5 and 7-position of the ring of 6 appeared as a AB system quartet. All ring methylene protons in 2 gave a singlet. The temperature dependent coalescence and splitting of the singals was observed in 1. At low temperature the 5, 7-methylene protons in thr ring of 1 gave a AB quartet and a singlet. From these facts it was suggested that 1 was amixture of the conformational isomer A and B in Fig. 8 and they could not freely rotate each other even at room temperaute. 6 existed only as the structure A. The Mass spectra of them were also reported.

  报告了 6-取代的 6, 7-二氢-5H-二苯并[b, g][1,5]恶唑嗪和噻唑嗪衍生物（1）、硫醚或砜类化合物（6）以及双分子十六分子环化合物（2）的核磁共振谱。6 环上 5 位和 7 位的亚甲基质子以 AB 系统四元组的形式出现。2 中的所有环亚甲基质子都呈现单重子。在低温下，1 环上的 5、7-亚甲基质子产生 AB 四元体和一个单体。从这些事实可以看出，1 是图 8 中构象异构体 A 和 B 的混合物，即使在室温下也不能自由旋转。同时还报告了它们的质谱图。
• [EN] PHTHALAZINE AND PYRIDO [3,4-D] PYRIDAZ INE COMPOUNDS AS H1 RECEPTOR ANTAGONISTS<br/>[FR] PHTHALAZINE ET COMPOSÉS PYRIDO-[3,4-D]PYRIDAZINE COMME ANTAGONISTES DU RÉCEPTEUR H1
  申请人：GLAXO GROUP LTD

  公开号：WO2009047336A1

  公开（公告）日：2009-04-16

  The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various diseases, such as allergic rhinitis.

  本发明涉及式(I)的化合物及其盐，其制备方法，含有它们的组合物以及它们在治疗各种疾病（如过敏性鼻炎）中的用途。