甲基-二聚乙二醇-琥珀酰亚胺酯 | 1127247-34-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 甲基-二聚乙二醇-琥珀酰亚胺酯
• 英文名称: (2,5-dioxopyrrolidin-1-yl)3-(2-methoxyethoxy)propanoate
• 英文别名: m-dPEG2-NHS ester；2,5-Dioxopyrrolidin-1-yl 3-(2-methoxyethoxy)propanoate；(2,5-dioxopyrrolidin-1-yl) 3-(2-methoxyethoxy)propanoate
• CAS: 1127247-34-0
• 化学式: C₁₀H₁₅NO₆
• 分子量: 245.232
• InChiKey: IMSXKORGOVQCNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  82.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• NOVEL CONJUGATES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
  申请人：BOUCHARD Hervé

  公开号：US20120225089A1

  公开（公告）日：2012-09-06

  Provided herein are cryptophycin conjugates and compositions containing them. Methods of making and using such compounds also are provided.

  本发明提供了隐藻素偶联物及其包含它们的组合物。还提供了制备和使用此类化合物的方法。
• [EN] INSULIN RECEPTOR PARTIAL AGONISTS AND GLP-1 ANALOGUES<br/>[FR] AGONISTES PARTIELS DU RÉCEPTEUR DE L'INSULINE ET ANALOGUES DU GLP-1
  申请人：MERCK SHARP & DOHME

  公开号：WO2017205191A1

  公开（公告）日：2017-11-30

  The present invention provides compositions comprising insulin receptor partial agonists in association with GLP-1 analogues (e.g., liraglutide) as well as methods for using the compositions for example, to treat or prevent diabetes or to decrease body weight.

  本发明提供了包含胰岛素受体部分激动剂与GLP-1类似物（例如利拉鲁肽）的组合物，以及使用该组合物的方法，例如用于治疗或预防糖尿病或减轻体重。
• TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE
  申请人：Steinmetzer Torsten

  公开号：US20100022781A1

  公开（公告）日：2010-01-28

  The invention relates to inhibitors of trypsin-like serine proteases of the general formula (I) which, as well as plasmin, also inhibit plasma kallikrien, and to their preparation and use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.

  该发明涉及一般式（I）的胰蛋白酶样丝氨酸蛋白酶抑制剂，除了抑制纤溶酶外，还抑制血浆激肽原，以及它们的制备和用作药物，优选用于治疗失血，特别是在高纤溶状态、器官移植或心脏手术干预，特别是心肺转流手术中，或作为纤维蛋白粘合剂的组分。
• Methods , composition and preparations for delivery of immune response modifiers
  申请人：Zarraga E. Isidro Angelo

  公开号：US20070166384A1

  公开（公告）日：2007-07-19

  A soluble IRM-polymer complex, preparations thereof, and methods of use, wherein the soluble IRM-polymer complex includes one or more IRM compounds attached (e.g., covalently attached) to a polymer (e.g., an alkylene oxide-containing polymer).

  一种可溶性IRM-聚合物复合物，其制备方法以及使用方法，其中可溶性IRM-聚合物复合物包括一个或多个IRM化合物与聚合物（例如，含有烷基氧的聚合物）连接（例如，共价连接）的情况。
• BIFUNCTIONAL CHELATING AGENTS
  申请人：GENERAL ELECTRIC COMPANY

  公开号：US20140088314A1

  公开（公告）日：2014-03-27

  A chelating agent, a metal-chelate, and a contrast agent are provided, wherein the chelating agent comprises a compound of structure (I) wherein R 1 , R 2 , R 3 , R 8 , R 7 , R′ 7 R′ 1 , R′ 2 , R′ 3 and R 8 ′ are selected from a hydrogen, a protected C 1 -C 3 hydroxyalkyl group, a C 1 -C 3 alkyl group; R 4 and R′ 4 are selected from a hydrogen, a hydroxyl group, a protected hydroxy group, a protected C 1 -C 3 hydroxyalkyl group, a C 1 -C 3 alkyl group; n is an integer between 0 and 4; R 5 and R′ 5 are selected from a hydrogen, a protecting group selected from the group consisting of C 1 -C 30 aliphatic radicals, C 3 -C 30 cycloaliphatic radicals, C 2 -C 30 aromatic radicals; R 9 and R′ 9 are selected form a hydrogen or a protecting group selected from the group consisting of C 1 -C 30 aliphatic radicals, C 3 -C 30 cycloaliphatic radicals, C 2 -C 30 aromatic radicals, m is an integer between 0 and 10; and at least one of R 7 and R′ 7 is acidic group or a protected acidic group.

  提供了一种螯合剂、金属螯合物和对比剂，其中螯合剂包括结构（I）的化合物，其中R1、R2、R3、R8、R7、R′7、R′1、R′2、R′3和R8′从氢、受保护的C1-C3羟基烷基基团、C1-C3烷基基团中选择；R4和R′4从氢、羟基、受保护的羟基、受保护的C1-C3羟基烷基基团、C1-C3烷基基团中选择；n是0到4之间的整数；R5和R′5从氢、选自C1-C30脂肪基、C3-C30环脂肪基、C2-C30芳香基的保护基中选择；R9和R′9从氢或选自C1-C30脂肪基、C3-C30环脂肪基、C2-C30芳香基的保护基中选择；m是0到10之间的整数；并且R7和R′7中的至少一个是酸性基团或受保护的酸性基团。