1-[(2R,3R,4R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-hydroxy-3-imidazol-1-yl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione | 143488-46-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-[(2R,3R,4R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-hydroxy-3-imidazol-1-yl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
• 英文别名: imidazol-1-yl(-2d)[TBDMS(-5)]Xylf(b)-uracil-1-yl；1-[(2R,3R,4R,5R)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-4-hydroxy-3-imidazol-1-yloxolan-2-yl]pyrimidine-2,4-dione
• CAS: 143488-46-4
• 化学式: C₁₈H₂₈N₄O₅Si
• 分子量: 408.53
• InChiKey: VEUWWQFQQGRWKS-DMRZNYOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.25
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  叔丁基二甲基氯硅烷 在 sodium hydride 作用下， 以 二甲基亚砜 为溶剂， 反应 0.5h， 生成 1-[(2R,3R,4R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-hydroxy-3-imidazol-1-yl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  Azide- or fluorine-containing 2′ & 3′-azolyluridines by regioselective opening of 1-(2′,3′-anhydro-β-d-lyxofuranosyl)uracils

  摘要：

  Azide- or fluorine-containing imidazol-1-yl, pyrazol-1-yl, and 1,2,4-triazol-1-yl 2',3'-dideoxyuridines have been synthesised from uridine in 5-6 steps, via <<2',3'-beta-epoxy>> derivatives. Regioselective oxirane-ring openings have been accomplished by appropriate choice of the reaction conditions.

  DOI：

  10.1016/0040-4039(92)88102-b

文献信息

• Azide- or fluorine-containing 2′ &amp; 3′-azolyluridines by regioselective opening of 1-(2′,3′-anhydro-β-d-lyxofuranosyl)uracils
  作者：Xavier Ariza、Josep Garcés、Jaume Vilarrasa

  DOI：10.1016/0040-4039(92)88102-b

  日期：1992.7

  Azide- or fluorine-containing imidazol-1-yl, pyrazol-1-yl, and 1,2,4-triazol-1-yl 2',3'-dideoxyuridines have been synthesised from uridine in 5-6 steps, via <<2',3'-beta-epoxy>> derivatives. Regioselective oxirane-ring openings have been accomplished by appropriate choice of the reaction conditions.