N-acetylmonoaza-18-crown-6 | 130469-33-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetylmonoaza-18-crown-6
• 英文别名: N-acetyl-1,4,7,10,13-pentaoxa-16-azacyclooctadecane；1-(1,4,7,10,13-Pentaoxa-16-azacyclooctadec-16-yl)ethanone
• CAS: 130469-33-9
• 化学式: C₁₄H₂₇NO₆
• 分子量: 305.371
• InChiKey: CGFDGOUOCWMYQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  66.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-acetylmonoaza-18-crown-6 在 lithium iodide 作用下， 生成 1-(1,4,7,10,13-Pentaoxa-16-aza-cyclooctadec-16-yl)-ethanone; compound with GENERIC INORGANIC NEUTRAL COMPONENT
  参考文献：
  名称：

  Alkali-metal cation recognition induced isomerization of spirobenzopyrans and spironaphthoxazins possessing a crown ring as a recognition site: multifunctional artificial receptors

  摘要：

  Spirobenzopyrans and spironaphthoxazins possessing a monoaza-crown ring were synthesized. Isomerization of these compounds to the open colored merocyanines was induced by recognition of alkali-metal cations and the selectivity of the coloration was found to be governed by several factors: (1) the size of the crown ring, (2) the position of recognition, (3) electric properties of both the complexed cations and the merocyanine dipoles, and (4) the length of the alkyl chains connecting the spirobenzopyran units and the crown units. The spirobenzopyrans represent rationally designed multifunctional artificial receptors for alkali-metal cations.

  DOI：

  10.1021/jo00046a019
• 作为产物：
  描述：

  1-(1,4,7,10,13-Pentaoxa-16-aza-cyclooctadec-16-yl)-ethanone; compound with GENERIC INORGANIC NEUTRAL COMPONENT 生成 N-acetylmonoaza-18-crown-6
  参考文献：
  名称：

  Alkali-metal cation recognition induced isomerization of spirobenzopyrans and spironaphthoxazins possessing a crown ring as a recognition site: multifunctional artificial receptors

  摘要：

  Spirobenzopyrans and spironaphthoxazins possessing a monoaza-crown ring were synthesized. Isomerization of these compounds to the open colored merocyanines was induced by recognition of alkali-metal cations and the selectivity of the coloration was found to be governed by several factors: (1) the size of the crown ring, (2) the position of recognition, (3) electric properties of both the complexed cations and the merocyanine dipoles, and (4) the length of the alkyl chains connecting the spirobenzopyran units and the crown units. The spirobenzopyrans represent rationally designed multifunctional artificial receptors for alkali-metal cations.

  DOI：

  10.1021/jo00046a019

文献信息

• Monofunctionalized Bambus[6]urils and Their Conjugates with Crown Ethers for Liquid–Liquid Extraction of Inorganic Salts
  作者：Kamil Maršálek、Vladimír Šindelář

  DOI：10.1021/acs.orglett.0c00216

  日期：2020.2.21

  a growing family of macrocyclic anion receptors. In this Letter, we present the first syntheses of monofunctionalized bambusurils and their use for the preparation of heteroditopic bambusuril-crown ether conjugates suitable for the extraction of ion pairs from water to chloroform.

  氨苄青霉素是大环阴离子受体的增长家族。在这封信中，我们介绍了单官能化樟脑丸的第一种合成方法，及其在制备异位脂族樟脑丸-冠状醚共轭物中的应用，这些共轭物适合于从水到氯仿中提取离子对。
• An artificial aspartic proteinase system
  作者：Lin Jiang、Zhilian Liu、Zhi Liang、Yunhua Gao

  DOI：10.1016/j.bmc.2005.03.026

  日期：2005.6

  A series of aza crown ether derivatives with or without carboxyl groups in their side arms were synthesized and the former showed deacylation activities toward amino acid p-nitrophenyl ester hydrohalides. Substrate-selective phenomena were also observed. The relationship between the structures and deacylation activities of corresponding compounds suggested a nucleophilic catalytic mechanism. The results partially simulate some aspartic proteinases in the case of catalytic mechanism and are also useful for us to understand the detailed catalytic process of aspartic proteinases. (c) 2005 Elsevier Ltd. All rights reserved.
• Alkali-metal cation recognition induced isomerization of spirobenzopyrans and spironaphthoxazins possessing a crown ring as a recognition site: multifunctional artificial receptors
  作者：Masahiko Inouye、Masaru Ueno、Kikuo Tsuchiya、Naomi Nakayama、Takashi Konishi、Teijiro Kitao

  DOI：10.1021/jo00046a019

  日期：1992.9

  Spirobenzopyrans and spironaphthoxazins possessing a monoaza-crown ring were synthesized. Isomerization of these compounds to the open colored merocyanines was induced by recognition of alkali-metal cations and the selectivity of the coloration was found to be governed by several factors: (1) the size of the crown ring, (2) the position of recognition, (3) electric properties of both the complexed cations and the merocyanine dipoles, and (4) the length of the alkyl chains connecting the spirobenzopyran units and the crown units. The spirobenzopyrans represent rationally designed multifunctional artificial receptors for alkali-metal cations.