2-((2,3-dichlorophenoxy)methyl)ethylene oxide | 21320-28-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((2,3-dichlorophenoxy)methyl)ethylene oxide
• 英文别名: 2-[(2,3-dichlorophenoxy)methyl]oxirane；(2S)-3-(2,3-dichlorophenoxy)-1,2-epoxypropane；3-(2,3-dichlorophenoxy)-1,2-epoxypropane；(R)-2,3-dichlorophenyl glycidyl ether
• CAS: 21320-28-5
• 化学式: C₉H₈Cl₂O₂
• 分子量: 219.067
• InChiKey: BGOUOFHQLQPABA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  21.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-甲氧基苯基)-2-甲基丙烷-2-胺 、 2-((2,3-dichlorophenoxy)methyl)ethylene oxide 生成 (R)-N-[2-Hydroxy-3-(2,3-dichlorophenoxy)propyl]-1,1-dimethyl-2-(4-methoxyphenyl)ethyl amine Hydrochloride
  参考文献：
  名称：

  Method of using calcilytic compounds

  摘要：

  本发明涉及钙受体拮抗剂化合物。"钙受体拮抗剂化合物"指的是能够抑制钙受体活性的化合物。还描述了利用钙受体拮抗剂化合物来抑制钙受体活性和/或在患者中达到有益效果的方法；以及可用于获取额外钙受体拮抗剂化合物的技术。

  公开号：

  US06022894A1

文献信息

• Studies on Agents with Vasodilator and ,B-Blocking Activities. IV.
  作者：Toshimi SEKI、Tomio NAKAO、Takeshi MASUDA、Kohichi HASUMI、Kotaro GOTANDA、Tsutomu ISHIMORI、Seijiro HONMA、Nobuyoshi MINAMI、Kenyu SHIBATA、Kikuo YASUDA

  DOI：10.1248/cpb.44.2061

  日期：——

  A series of novel pyridazinone derivatives (II) having a phenoxypropanolamine moiety was synthesized. Their hypotensive and β-blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Among them, the 5-chloro-2-cyanophenoxy derivative (29) showed the promising dual activities and was selected for further studies.

  合成了一系列具有苯氧基丙醇胺结构的新型哒嗪酮衍生物（II）。在静脉注射给麻醉大鼠后，评估了它们的降压和β-阻断活性。其中，5-氯-2-氰基苯氧基衍生物（29）显示出有前途的双重活性，并被选中进行进一步研究。
• Studies on Agents with Vasodilator and .BETA.-Blocking Activities. II.
  作者：Toshimi SEKI、Takayuki TAKEZAKI、Rikio OHUCHI、Hiroshi OHUYABU、Yoshitaka TANIMOTO、Takashi YAMAGUCHI、Norinobu SAITOH、Tsutomu ISHIMORI、Kikuo YASUDA

  DOI：10.1248/cpb.43.247

  日期：——

  A series of phenoxypropanolamines having a hydrazinopyridazinyl moiety was synthesized. Their hypotensive and β-blocking activities were evaluated after intravenous administration of the compounds to anethetized rats.Some of them exhibited both activities. In particular, compound 20k is a candidate for clinical use due to its hypotensive activity, equal to that of hydralazine, and its β-blocking activity, 2.7-fold more potent than that of propranolol.

  一系列含有哒嗪基肼结构的苯氧丙醇胺类化合物被合成，并通过静脉注射给麻醉大鼠后评估了它们的降压和β阻断活性。其中一些化合物显示了这两种活性。特别是化合物20k，由于其降压活性与肼达嗪相当，且β阻断活性比普萘洛尔强2.7倍，因此被认为是临床应用的候选药物。
• Aralkyl or aryloxyalkyl 1,7-naphthyridine-3-carboxylic acid esters
  申请人：American Home Products Corporation

  公开号：US04551534A1

  公开（公告）日：1985-11-05

  7-(Substituted)-1,4,5,6,7,8-hexahydro-2-alkyl-4-aryl-5-oxo-1,7-naphthyridin e-3-carboxylic acid esters and pharmaceutically acceptable acid addition salts thereof are useful antihypertensive agents.

  7-(替代)-1,4,5,6,7,8-六氢-2-烷基-4-芳基-5-酮-1,7-萘啶-3-羧酸酯及其药学上可接受的酸盐是有用的降压药物。
• [EN] PIPERIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND ITS USE<br/>[FR] COMPOSES DE PIPERIDINE, COMPOSITION PHARMACEUTIQUE LES CONTENANT ET UTILISATION ASSOCIEE
  申请人：SK HOLDINGS CO LTD

  公开号：WO2010044585A2

  公开（公告）日：2010-04-22

  Piperidine compounds and pharmaceutically useful salts thereof, a pharmaceutical composition including an effective amount of the racemic or enantiomerically enriched piperidine compounds to treat gastrointestinal diseases, and a method of treating gastrointestinal diseases in a mammal are provided.

  本发明提供了吡啶化合物及其药用盐，一种包括有效量的外消旋或对映富集的吡啶化合物的制药组合物，用于治疗哺乳动物的胃肠疾病的方法。
• PIPERIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND ITS USE
  申请人：SK BIOPHARMACEUTICALS CO., LTD.

  公开号：US20140135314A1

  公开（公告）日：2014-05-15

  Piperidine compounds and pharmaceutically useful salts thereof, a pharmaceutical composition including an effective amount of the racemic or enantiomerically enriched piperidine compounds to treat gastrointestinal diseases, and a method of treating gastrointestinal diseases in a mammal are provided.

  本发明提供了吡啶化合物及其药用盐，以及包括有效量的外消旋或对映富集的吡啶化合物的药物组合物，用于治疗胃肠疾病，并提供一种治疗哺乳动物胃肠疾病的方法。