(5Z)-5-{2-[3-(dimethylamino)pyrrolidin-1-yl]benzylidene}-1,3-thiazolidine-2,4-dione | 1203793-59-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (5Z)-5-{2-[3-(dimethylamino)pyrrolidin-1-yl]benzylidene}-1,3-thiazolidine-2,4-dione
• 英文别名: (5Z)-5-[[2-[3-(dimethylamino)pyrrolidin-1-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dione
• CAS: 1203793-59-2
• 化学式: C₁₆H₁₉N₃O₂S
• 分子量: 317.412
• InChiKey: PRQMWOGCLLGXFR-ZROIWOOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  78
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-(二甲氨基)吡咯烷 、 2-氟苯甲醛 在 哌啶 、 potassium carbonate 作用下， 以 乙醇 为溶剂， 生成 (5Z)-5-{2-[3-(dimethylamino)pyrrolidin-1-yl]benzylidene}-1,3-thiazolidine-2,4-dione
  参考文献：
  名称：

  Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases

  摘要：

  Novel substituted benzylidene-1,3-thiazolidine-2,4-diones (TZDs) have been identified as potent and highly selective inhibitors of the PIM kinases. The synthesis and SAR of these compounds are described, along with X-ray crystallographic, anti-proliferative, and selectivity data. (C) 2012 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2012.05.098

文献信息

• CHEMICAL COMPOUNDS 251
  申请人：Dakin Leslie

  公开号：US20110218182A1

  公开（公告）日：2011-09-08

  The invention relates to chemical compounds of formula (I), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of PIM-1 and/or PIM-2, and/or PIM-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of PIM kinase related conditions and diseases, preferably cancer.

  该发明涉及化学式(I)的化合物及其盐。在某些实施例中，该发明涉及PIM-1和/或PIM-2以及/或PIM-3蛋白激酶活性或酶功能的抑制剂或调节剂。在更进一步的实施例中，该发明涉及包含本文披露的化合物的药物组合物，以及它们在预防和治疗PIM激酶相关疾病和疾病，特别是癌症中的用途。
• Chemical Compounds 251
  申请人：AstraZeneca AB

  公开号：US20150051185A1

  公开（公告）日：2015-02-19

  The invention relates to chemical compounds of formula I, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of PIM-1 and/or PIM-2, and/or PIM-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of PIM kinase related conditions and diseases, preferably cancer.

  本发明涉及公式I的化合物及其盐。在某些实施例中，本发明涉及PIM-1和/或PIM-2，以及/或PIM-3蛋白激酶活性或酶功能的抑制剂或调节剂。在更进一步的实施例中，本发明涉及包含本文所披露的化合物的制药组合物，以及它们在预防和治疗PIM激酶相关的疾病和状况，尤其是癌症方面的应用。
• US8901307B2
  申请人：——

  公开号：US8901307B2

  公开（公告）日：2014-12-02
• [EN] CHEMICAL COMPOUNDS 251<br/>[FR] COMPOSÉS CHIMIQUES 251
  申请人：ASTRAZENECA AB

  公开号：WO2010001169A2

  公开（公告）日：2010-01-07

  The invention relates to chemical compounds of formula (I), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of PIM-1 and/or PIM-2, and/or PIM-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of PIM kinase related conditions and diseases, preferably cancer.
• Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases
  作者：Les A. Dakin、Michael H. Block、Huawei Chen、Erin Code、James E. Dowling、Xiaomei Feng、Andrew D. Ferguson、Isabelle Green、Alexander W. Hird、Tina Howard、Erika K. Keeton、Michelle L. Lamb、Paul D. Lyne、Hannah Pollard、Jon Read、Allan J. Wu、Tao Zhang、Xiaolan Zheng

  DOI：10.1016/j.bmcl.2012.05.098

  日期：2012.7

  Novel substituted benzylidene-1,3-thiazolidine-2,4-diones (TZDs) have been identified as potent and highly selective inhibitors of the PIM kinases. The synthesis and SAR of these compounds are described, along with X-ray crystallographic, anti-proliferative, and selectivity data. (C) 2012 Published by Elsevier Ltd.