3-(pentan-3-yl)-1-tosyl-1H-pyrazole | 1276088-23-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(pentan-3-yl)-1-tosyl-1H-pyrazole
• 英文别名: 1-(4-Methylphenyl)sulfonyl-3-pentan-3-ylpyrazole
• CAS: 1276088-23-3
• 化学式: C₁₅H₂₀N₂O₂S
• 分子量: 292.402
• InChiKey: VONZACTURLZGSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  60.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2-diethyl-3-ethoxycyclobutanone 、 对甲苯磺酰肼 在 四氯化锡 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以93%的产率得到3-(pentan-3-yl)-1-tosyl-1H-pyrazole
  参考文献：
  名称：

  A New Synthesis of Pyrazoles through a Lewis Acid Catalyzed Union of 3-Ethoxycyclobutanones with Monosubstituted Hydrazines

  摘要：

  A new efficient and convenient approach toward the synthesis of pyrazoles is described. Through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with monosubstituted hydrazines, a variety of pyrazole derivatives were prepared readily at ambient temperature with complete regioselectivity.

  DOI：

  10.1021/ol2002682

文献信息

• A New Synthesis of Pyrazoles through a Lewis Acid Catalyzed Union of 3-Ethoxycyclobutanones with Monosubstituted Hydrazines
  作者：Gang Shan、Pengfei Liu、Yu Rao

  DOI：10.1021/ol2002682

  日期：2011.4.1

  A new efficient and convenient approach toward the synthesis of pyrazoles is described. Through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with monosubstituted hydrazines, a variety of pyrazole derivatives were prepared readily at ambient temperature with complete regioselectivity.