2-羟基-2-苯基乙烷-磺酸 | 107100-11-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-羟基-2-苯基乙烷-磺酸
• 英文名称: 2-phenyl-2-hydroxyethanesulfonic acid
• 英文别名: 2-hydroxy-2-phenylethane-sulfonic acid；2-Phenyl-1-hydroxyethan-1-sulfonsaeure；2-Hydroxy-2-phenyl-aethansulfonsaeure；1-Hydroxy-1-phenyl-aethan-sulfonsaeure-(2)；2-Hydroxy-2-phenylethanesulfonic acid
• CAS: 107100-11-8
• 化学式: C₈H₁₀O₄S
• 分子量: 202.231
• InChiKey: SPVVJQWXLZJDOT-UHFFFAOYSA-N

物化性质

• 密度：
  1.454±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-羟基-2-苯基乙烷-磺酸 在 五氯化磷 作用下， 生成 (E)-2-phenylethene-1-sulfonic acid
  参考文献：
  名称：

  The Peroxide Effect in the Addition of Reagents to Unsaturated Compounds. XXIII. The Reaction of Styrene with Bisulfite

  摘要：

  DOI：

  10.1021/ja01266a034
• 作为产物：
  描述：

  2-phenyl-ethenesulfonic acid 4-chlorophenyl ester 在 alkalia 作用下， 以 1,4-二氧六环 、 水 为溶剂， 生成 2-羟基-2-苯基乙烷-磺酸
  参考文献：
  名称：

  Vizgert, R. V.; Enya, V. I.; Tuchapskii, I. M., Journal of general chemistry of the USSR, 1986, vol. 56, # 11, p. 2318 - 2322

  摘要：

  DOI：

文献信息

• [EN] A METHOD FOR PREPARING SULFUR-CONTAINING COMPOUNDS<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION DE COMPOSÉS CONTENANT DU SOUFRE
  申请人：ROYAL COLLEGE OF SURGEONS IE

  公开号：WO2010066450A1

  公开（公告）日：2010-06-17

  The invention provides a method for preparing sulfur-containing compounds, the method comprising reacting a donor compound comprising at least one sulfur having at least one lone pair of electrons, with an acceptor compound; wherein the reaction occurs in the presence of an amine, optionally an amine catalyst, capable of activating the sulfur having at least one lone pair of electrons; and wherein the reaction occurs via the formation of an transient intermediate species, optionally a transient intermediate species, between the amine, optionally the amine catalyst and the donor compound; and wherein the donor compound is selected from the group consisting of a sulfurous acid, a sulfenic acid and a sulfinic acid or a salt, ester or amide of a sulfurous acid, a sulfenic acid and a sulfinic acid. The invention also provides sulfur-containing compounds of the formula: wherein R is selected from: (a) 1 -(4-Nitro-phenyl)-3-oxo-3-phenyl-propane; (b) 2-(3-Methyl-4-nitro-isoxazol-5-yl)-1 -phenyl-ethane; (c) 1-(4-Methoxy-phenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane; (d) 2-(3-Methyl-4-nitro-isoxazol-5-yl)-1-(4-nitro-phenyl)-ethane; (e) 1-(4-Fluoro-phenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane; (f) 1 -(4-Chloro-phenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane; and (g) 3-Oxo-cyclohexane. Finally, the invention provides use of chiral sulfur-containing compounds obtainable by the above-mentioned method or chiral sulfur-containing compounds as mentioned above for the resolution of racemic mixtures of amines.

  该发明提供了一种制备含硫化合物的方法，该方法包括将包含至少一个硫原子且至少一个孤对电子的给体化合物与受体化合物反应；其中，在胺的存在下进行反应，可选地，在能够激活至少一个硫原子具有至少一个孤对电子的胺的存在下进行反应；反应通过形成瞬态中间体物种进行，可选地，通过胺、可选地胺催化剂和给体化合物之间的瞬态中间体物种进行反应；给体化合物选自包括亚硫酸、亚硫酸和亚砜酸或亚硫酸、亚硫酸和亚砜酸的盐、酯或酰胺的群；该发明还提供了符合以下公式的含硫化合物：其中R选自：(a) 1-(4-硝基苯基)-3-氧代-3-苯基-丙烷；(b) 2-(3-甲基-4-硝基异噁唑-5-基)-1-苯基-乙烷；(c) 1-(4-甲氧基苯基)-2-(3-甲基-4-硝基异噁唑-5-基)-乙烷；(d) 2-(3-甲基-4-硝基异噁唑-5-基)-1-(4-硝基苯基)-乙烷；(e) 1-(4-氟苯基)-2-(3-甲基-4-硝基异噁唑-5-基)-乙烷；(f) 1-(4-氯苯基)-2-(3-甲基-4-硝基异噁唑-5-基)-乙烷；和(g) 3-氧代环己烷。最后，该发明提供了通过上述方法获得的手性含硫化合物或上述提到的手性含硫化合物用于分离胺的外消旋混合物。
• PROCESS FOR PREPARING AMIDOALKANESULFONIC ACID DERIVATIVES
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0112921A1

  公开（公告）日：1984-07-11

  A novel process for preparing amidoalkanesulfonic acids represented by formula (3) and their derivatives by reacting a nitrile compound (1) with p-hydroxyalkanesulfonic acid or its derivative (2) in conc. sulfuric acid. Of the compounds of the formula (3) and their derivatives, unsaturated amidophenyl- substitued alkanesulfonic acids represented by formula (4) and their derivatives, particularly, 2-acrylamido-2-phenylpropanesulfonic acid and its derivatives are copolymerized with other monomers to provide useful materials such as copolymer-coated solid substances, copolymer emulsions, and pigment-dispersing agent.

  一种新工艺，通过腈化合物（1）与对羟基烷磺酸或其衍生物（2）在浓硫酸中反应，制备以式（3）为代表的氨基烷磺酸及其衍生物。在式 (3) 及其衍生物中，式 (4) 所代表的不饱和氨基苯基取代烷磺酸及其衍生物，特别是 2-丙烯酰胺基-2-苯基丙磺酸及其衍生物，可与其他单体共聚，以提供有用的材料，如共聚物涂层固体物质、共聚物乳液和颜料分散剂。
• ACETALSULFONATE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING STYRENE OXIDE DERIVATIVE
  申请人：Mitsubishi Rayon Co., Ltd.

  公开号：EP1236714A1

  公开（公告）日：2002-09-04

  There are provided an acetalsulfonate derivative useful as an intermediate for medicines and agricultural chemicals, a process for industrially producing the derivative, and a process for industrially producing a styrene oxide derivative from the acetalsulfonate derivative or from a mandelic acid derivative. A process for producing an acetalsulfonate derivative which comprises a first step of esterifying a mandelic acid derivative to form a mandelic ester derivative, a second step of protecting the mandelic ester derivative by an acetal to form an acetal derivative, a third step of reducing the acetal derivative to form an ethanediol derivative and a fourth step of reacting the ethanediol derivative with a sulfonyl chloride derivative. A process for producing a styrene oxide derivative which comprises a deprotecting step of deacetalizing the acetalsulfonate derivative and a step of epoxidizing the sulfonate derivative obtained in the deprotecting step with the aid of a base catalyst.

  本发明提供了一种可用作医药和农用化学品中间体的乙醛磺酸衍生物、一种工业化生产该衍生物的工艺，以及一种用乙醛磺酸衍生物或扁桃酸衍生物工业化生产氧化苯乙烯衍生物的工艺。 一种生产乙醛磺酸衍生物的工艺，包括第一步酯化扁桃酸衍生物以形成扁桃酸酯衍生物，第二步用缩醛保护扁桃酸酯衍生物以形成缩醛衍生物，第三步还原缩醛衍生物以形成乙二醇衍生物，第四步使乙二醇衍生物与磺酰氯衍生物反应。一种生产氧化苯乙烯衍生物的工艺，该工艺包括使乙醛磺酸衍生物脱乙醛的脱保护步骤和在碱催化剂的帮助下使脱保护步骤中得到的磺酸衍生物环氧化的步骤。
• A method for preparing sulfur-containing compounds
  申请人：The Royal College of Surgeons in Ireland

  公开号：EP2196456A1

  公开（公告）日：2010-06-16

  The invention provides a method for preparing sulfur-containing compounds, the method comprising reacting a donor compound comprising at least one sulfur having at least one lone pair of electrons, with an acceptor compound; wherein the reaction occurs in the presence of a catalyst capable of activating the sulfur having at least one lone pair of electrons. The invention also provides sulfur-containing compounds of the formula: wherein R is selected from: (a) 1-(4-Nitro-phenyl)-3-oxo-3-phenyl-propane; (b) 2-(3-Methyl-4-nitro-isoxazol-5-yl)-1-phenyl-ethane; (c) 1-(4-Methoxy-phenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane; (d) 2-(3-Methyl-4-nitro-isoxazol-5-yl)-1-(4-nitro-phenyl)-ethane; (e) 1-(4-Fluoro-phenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane; (f) 1-(4-Chloro-phenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane; (g) 3-Oxo-butane; (h) 2-Methyl-4-oxo-pentane-2-yl; (i) 3,4-Dihydroxy-naphthalene-2-yl; and (j) 3-Oxo-cyclohexane. Finally, the invention provides use of chiral sulfur-containing compounds obtainable by the above-mentioned method or chiral sulfur-containing compounds as mentioned above for the resolution of racemic mixtures of amines.

  本发明提供了一种制备含硫化合物的方法，该方法包括使包含至少一个具有至少一对孤对电子的硫的供体化合物与受体化合物反应；其中反应是在能够活化具有至少一对孤对电子的硫的催化剂存在下进行的。 本发明还提供了式中的含硫化合物： 其中 R 选自 (a) 1-(4-硝基苯基)-3-氧代-3-苯基-丙烷； (b) 2-(3-甲基-4-硝基异恶唑-5-基)-1-苯基乙烷； (c) 1-(4-甲氧基苯基)-2-(3-甲基-4-硝基异恶唑-5-基)-乙烷 (d) 2-(3-甲基-4-硝基-异恶唑-5-基)-1-(4-硝基苯基)-乙烷 (e) 1-(4-氟苯基)-2-(3-甲基-4-硝基-异恶唑-5-基)乙烷 (f) 1-(4-氯苯基)-2-(3-甲基-4-硝基异恶唑-5-基)乙烷； (g) 3-氧代丁烷 (h) 2-Methyl-4-oxo-pentane-2-yl; (i) 3,4-二羟基-2-萘基；以及 (j) 3-氧代环己烷。 最后，本发明提供了可通过上述方法获得的手性含硫化合物或上述手性含硫化合物在胺外消旋混合物解析中的用途。
• Method for producing synthetic polymerizates with a very low residual monomer content, products produced according to this method and the use thereof
  申请人：Stockhausen GmbH & Co. KG

  公开号：US20030027961A1

  公开（公告）日：2003-02-06

  The invention relates to a process for producing water-soluble or water-swellable polymer products with low levels of residual monomers using acrylic acid and/or acrylic acid derivatives, which process is characterized by adding a nitrogen compound to the monomer solution to be polymerized and subsequent heating of the polymer product at temperatures of from 120 to 240° C. The polymers produced accordingly are suitable for use as flocculants, dispersants and absorbents.

  本发明涉及一种使用丙烯酸和/或丙烯酸衍生物生产残留单体含量低的水溶性或水溶性聚合物产品的工艺，该工艺的特点是在待聚合的单体溶液中加入氮化合物，然后在 120 至 240°C 的温度下加热聚合物产品。