4-(1-dimethylamino-ethyl)-phenol | 82965-48-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(1-dimethylamino-ethyl)-phenol
• 英文别名: Dimethyl-(4-oxy-α-phenaethyl)-amin；4-(1-Dimethylamino-aethyl)-phenol；p-Oxyphenylathyldimethylamin；4-[1-(dimethylamino)ethyl]phenol
• CAS: 82965-48-8
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: BSBYBIFCRACFFD-UHFFFAOYSA-N

物化性质

• 熔点：
  115 °C
• 沸点：
  230.9±15.0 °C(Predicted)
• 密度：
  1.021±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-溴-5,6-二甲氧基-1-茚酮 、 4-(1-dimethylamino-ethyl)-phenol 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成 2-[4-(1-Dimethylamino-ethyl)-phenoxy]-5,6-dimethoxy-indan-1-one
  参考文献：
  名称：

  Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors

  摘要：

  A series of 2-phenoxy-indan-1-one derivatives have been designed, synthesized, and tested as acetylcholinesterase inhibitors. The most potent compound exhibited high AChE inhibitory activity (IC50 = 50 nM), and the molecular docking study indicated that it was nicely accommodated by AChE. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.132
• 作为产物：
  描述：

  (R,S)-NN-dimethyl-1-p-methoxyphenylethylamine 在 氢溴酸 作用下， 生成 4-(1-dimethylamino-ethyl)-phenol
  参考文献：
  名称：

  Stedman; Stedman, Journal of the Chemical Society, 1929, p. 613

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE COMPOUNDS USING TRANSFER HYDROGENATION<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS OPTIQUEMENT ACTIFS PAR HYDROGÉNATION PAR TRANSFERT
  申请人：NOVARTIS AG

  公开号：WO2010072798A1

  公开（公告）日：2010-07-01

  A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drag substances. In particular, the process relates to the preparation of (S)-3-(1-Dimethylamino-ethyl)-phenol using asymmetric catalytic reduction and transfer hydrogenation, thereby providing an improved route to forming drug substances such as rivastigimine and rivastigimine hydrogen tartrate.

  一种用于制备光学活性化合物并将其转化为所需药物物质的催化过程。特别是，该过程涉及使用不对称催化还原和转移氢化制备(S)-3-(1-二甲氨基乙基)-苯酚，从而提供了一种改进的制备药物物质如利伐替普和利伐替普氢酒石酸盐的途径。
• Substituted 3-Haloallylamine Inhibitors of SSAO and uses thereof
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20160244406A1

  公开（公告）日：2016-08-25

  The present invention is related to the preparation and pharmaceutical use of substituted 3-haloallylamine derivatives as SSAO/VAP-1 inhibitors having the structure of Formula I, as defined in the specification: The invention also relates to methods of using compounds of Formula I, or pharmaceutically acceptable salt or derivatives thereof, for the treatment of a variety of indications, e.g., inflammatory diseases, ocular diseases, fibrotic diseases, diabetes-induced diseases and cancer.

  本发明涉及制备和药物应用具有式I结构的取代3-卤代烯丙胺衍生物作为SSAO/VAP-1抑制剂。该式在说明书中定义。本发明还涉及使用式I化合物或其药学上可接受的盐或衍生物的方法，用于治疗各种疾病，例如炎症性疾病、眼部疾病、纤维化疾病、糖尿病引起的疾病和癌症。
• Composition, and method of using the composition, effective for minimizing the harmful effects associated with individuals suffering from alcohol intoxication
  申请人：GDB Patent Holdings, LLC

  公开号：US10028991B2

  公开（公告）日：2018-07-24

  The present invention relates to a composition, and methods of using the composition, for minimizing the harmful effects associated with alcohol consumption. The composition includes a plurality of ingredients, which when combined, have the unexpected effect of increasing one or more metabolic pathways in the individual. As the metabolic rate is increased, alcohol is burned off, or utilized as energy source, and occurs at a considerably much faster rate than under normal physiological means. It is believed that the composition may have an effect on the brain causing it to increase metabolic rates. By administering the composition to an inebriated individual, the rate at which a person sobers up, occurs at a faster rate than would occur under normal physiological time frames.

  本发明涉及一种组合物和使用该组合物的方法，用于最大限度地减少与饮酒有关的有害影响。该组合物包括多种成分，当这些成分结合在一起时，会产生意想不到的效果，增加人体内的一种或多种新陈代谢途径。随着新陈代谢率的提高，酒精会被燃烧掉，或被用作能量来源，而且燃烧速度比正常生理情况下快很多。据信，这种成分可能会对大脑产生影响，使其提高新陈代谢率。通过给醉酒的人服用这种成分，人清醒的速度会比正常生理情况下更快。
• Polymer derivatives for the treatment of metals
  申请人：Fernandez Gonzalez Monica

  公开号：US20050121114A1

  公开（公告）日：2005-06-09

  A composition for the treatment of metal surfaces and for the deposition of metals or metal alloys on plastics surfaces contains a) at least one polymer as component A, composed of the structural element (1) and at least three structural elements selected from the group consisting of b) water or another solvent which is suitable for dissolving, dispersing, suspending or emulsifying the polymer, as component B; c) if required, surface-active compounds, dispersants, suspending media and/or emulsifiers as component C. In a process for the treatment of a metal surface and a process for the deposition of metals or metal alloys on a plastics surface, the metal or plastics surface is brought into contact with a polymer (component A). Furthermore, polymers (component A) are used for the treatment of metal surfaces and for the deposition of metals or metal alloys on a plastics surface, and polymers composed of special components A′a, A′b and A′c.

  一种用于处理金属表面和在塑料表面沉积金属或金属合金的组合物包含 a) 至少一种聚合物作为 A 组分，由结构元素（1）和至少三种结构元素组成。 和至少三个结构单元组成，这三个结构单元选自以下组别 在处理金属表面和在塑料表面沉积金属或金属合金的工艺中，金属或塑料表面与聚合物 （组分 A）接触。）此外，用于处理金属表面和在塑料表面沉积金属或金属合金的聚合物（组分 A），以及由特殊组分 A′a、A′b 和 A′c 组成的聚合物。
• PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE COMPOUNDS USING TRANSFER HYDROGENATION
  申请人：Novartis AG

  公开号：EP2382172A1

  公开（公告）日：2011-11-02