4-Methoxy-6-phenyl-hexan-2-on | 52117-35-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Methoxy-6-phenyl-hexan-2-on
• 英文别名: 4-Methoxy-6-phenylhexan-2-one
• CAS: 52117-35-8
• 化学式: C₁₃H₁₈O₂
• 分子量: 206.285
• InChiKey: YEPUGNNLAZUZQY-UHFFFAOYSA-N

物化性质

• 沸点：
  328.5±35.0 °C(Predicted)
• 密度：
  0.988±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙酸异丙烯酯 、 1,1-二甲氧基-3-苯基丙烷 在 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 生成 4-Methoxy-6-phenyl-hexan-2-on
  参考文献：
  名称：

  在路易斯酸的存在下，烯醇乙酸酯与缩醛和羰基化合物的反应

  摘要：

  发现在路易斯酸如 TiCl4、AlCl3、SnCl4、ZnCl2 和 BF3·O(C2H5)2 的存在下，烯醇乙酸酯与各种缩醛和苯甲醛反应，以良好的收率得到相应的醇醛型加成产物.

  DOI：

  10.1246/cl.1974.323

文献信息

• Aldol-Type Reaction by Propen-2-yl Acetate with NCS/SnCl₂/ROH
  作者：Yoshiro Masuyama、Yumiko Kobayashi、Ryota Yanagi、Yasuhiko Kurusu

  DOI：10.1246/cl.1992.2039

  日期：1992.10

  The addition of N-chlorosuccinimide (NCS) to a solution of propen-2-yl acetate, aldehydes, SnCl2, and benzyl alcohol in CH2Cl2 or CH3CN caused an aldol-type reaction to produce 4-substituted 4-benzyloxybutan-2-ones in high yields. Use of methanol instead of benzyl alcohol produced not only 4-methoxybutan-2-one but also 3-buten-2-one by dehydromethoxylation.

  将N-氯代琥珀酰亚胺(NCS)加入到丙烯酸-2-乙酯、醛、SnCl2和苄醇在CH2Cl2或CH3CN的溶液中，会导致一种Aldol型反应，从而高效生成4-取代-4-苄氧基丁烷-2-酮。如果用甲醇替代苄醇，不仅生成了4-甲氧基丁烷-2-酮，而且还通过脱氢甲氧基化产生了3-丁烯-2-酮。
• <scp>l</scp>-Proline-Catalyzed One-Pot Three-Component Reaction for the Synthesis of β-Alkoxy Ketones
  作者：Cong-Gui Zhao、Rajasekhar Dodda

  DOI：10.1055/s-2006-950184

  日期：——

  reaction of aliphatic aldehydes, ketones, and alcohols catalyzed by L-proline. Steric effects on the reaction were studied with substituted ketones, aldehydes, and alcohols, and the results indicate that reactions employing methyl ketones, α-unsubstituted aliphatic aldehydes and methanol produce the β-alkoxy ketones in the best yields when L-proline is used as the catalyst. The reaction mechanism is discussed

  L-脯氨酸催化脂肪醛、酮和醇的一锅三组分反应制备β-烷氧基酮。研究了取代酮、醛和醇对反应的空间位阻效应，结果表明，使用甲基酮、α-未取代脂肪醛和甲醇的反应以 L-脯氨酸为原料时生成 β-烷氧基酮的产率最高。催化剂。讨论了反应机理。
• METHOD FOR SEPARATING TARGET COMPONENT
  申请人：Imamura Takeshi

  公开号：US20090029423A1

  公开（公告）日：2009-01-29

  A construct in which at least a part of the magnetic material is coated with a polyhydroxyalkanoate (PHA), and a method for producing a construct by immobilizing a PHA synthesizing enzyme on the surface of the magnetic material, thereby biosynthesizing and coating a PHA.

  一种构造体，其中至少部分磁性材料被聚羟基脂肪酸酯（PHA）涂覆，并通过将PHA合成酶固定在磁性材料表面上，从而生物合成和涂覆PHA的方法来制备构造体。
• Structured construct and producing method therefor
  申请人：Imamura Takeshi

  公开号：US20070003975A1

  公开（公告）日：2007-01-04

  There is provided a construct in which at least a part of the magnetic material is coated with a polyhydroxyalkanoate (PHA), and a method for producing a construct by immobilizing a PHA synthesizing enzyme on the surface of the magnetic material, thereby biosynthesizing and coating a PHA.

  提供了一种构造，其中至少部分磁性材料被涂覆了聚羟基脂肪酸酯（PHA），以及一种通过将PHA合成酶固定在磁性材料表面上来生物合成和涂覆PHA的构造制备方法。
• POLYHYDROXYALKANOATE-CONTAINING STRUCTURE AND MANUFACTURING METHOD THEREOF
  申请人：Nomoto Tsuyoshi

  公开号：US20090061498A1

  公开（公告）日：2009-03-05

  A method for manufacturing polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with polyhydroxyalkanoate, the method comprises the steps of immobilizing a polyhydroxyalkanoate synthase on the base material surface, synthesizing, on the base material surface, polyhydroxyalkanoate using a 3-hydroxyacyl coenzyme A to become the substrate of the synthase and the synthase and coating at least a part of the base material surface with the synthesized polyhydroxyalkanoate, wherein the synthase contains an amino acid sequence capable of binding to the base material. A polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with a polyhydroxyalkanoate, comprises the base material, a polyhydroxyalkanoate synthase immobilized on the base material surface, and the polyhydroxyalkanoate with which at least a part of the base material surface is coated, wherein the synthase contains an amino acid sequence capable of binding to the base material.

  一种制造含有聚羟基脂肪酸酯的结构的方法，该结构的基材表面至少部分涂覆有聚羟基脂肪酸酯，该方法包括以下步骤：将聚羟基脂肪酸酯合酶固定在基材表面上，使用3-羟基酰辅酶A作为合酶的底物，在基材表面合成聚羟基脂肪酸酯，并用合成的聚羟基脂肪酸酯涂覆基材表面的至少一部分，其中合酶含有能够与基材结合的氨基酸序列。一种含有聚羟基脂肪酸酯的结构，该结构的基材表面至少部分涂覆有聚羟基脂肪酸酯，包括基材、固定在基材表面上的聚羟基脂肪酸酯合酶和至少一部分涂覆有聚羟基脂肪酸酯的基材表面，其中合酶含有能够与基材结合的氨基酸序列。