(2,6-dichlorobenzylidene)(2-fluorophenyl)amine | 1186017-86-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,6-dichlorobenzylidene)(2-fluorophenyl)amine
• 英文别名: 1-(2,6-dichlorophenyl)-N-(2-fluorophenyl)methanimine
• CAS: 1186017-86-6
• 化学式: C₁₃H₈Cl₂FN
• 分子量: 268.118
• InChiKey: AYSXRIOMBJXBJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氟苯胺 、 2,6-二氯苯甲醛 以 甲醇 为溶剂， 反应 3.0h， 以83%的产率得到(2,6-dichlorobenzylidene)(2-fluorophenyl)amine
  参考文献：
  名称：

  Schiff Bases as Potential Fungicides and Nitrification Inhibitors

  摘要：

  A number of substituted Schiff bases were synthesized and characterized by H-1 NMR and mass spectrometry. These compounds were screened for antifungal activity in vitro against pathogenic fungi, namely, Sclerotium rolfsii and Rhizoctonia bataticola, and for their effect on nitrification inhibition under laboratory conditions. Maximum antifungal activity was exhibited by (2,4-dichloroben ylidene)-(2,4,5-trichlorophenyl)-amine and (3-nitrobenzylidene)-(2,4,5-trichlorophenyl)-amine against both fungi (ED50 with range from 3 to 24 mu g/mL). Maximum nitrification inhibition (NI) was exhibited by (2,4-dichlorobenzylidene)-(2-fluorophenyl)-amine,(4-fluorophenyl)-(3-nitrobenzylidene)amine, (2,6-dichlorobenzylidene)-(4-fluorophenyl)-amine, and (2,6-dichlorobenzylidene)-(3 fluorophenyl)amine (NI in the range 91-96%).

  DOI：

  10.1021/jf902035w

文献信息

• Schiff Bases as Potential Fungicides and Nitrification Inhibitors
  作者：Nisha Aggarwal、Rajesh Kumar、Prem Dureja、Diwan S. Rawat

  DOI：10.1021/jf902035w

  日期：2009.9.23

  A number of substituted Schiff bases were synthesized and characterized by H-1 NMR and mass spectrometry. These compounds were screened for antifungal activity in vitro against pathogenic fungi, namely, Sclerotium rolfsii and Rhizoctonia bataticola, and for their effect on nitrification inhibition under laboratory conditions. Maximum antifungal activity was exhibited by (2,4-dichloroben ylidene)-(2,4,5-trichlorophenyl)-amine and (3-nitrobenzylidene)-(2,4,5-trichlorophenyl)-amine against both fungi (ED50 with range from 3 to 24 mu g/mL). Maximum nitrification inhibition (NI) was exhibited by (2,4-dichlorobenzylidene)-(2-fluorophenyl)-amine,(4-fluorophenyl)-(3-nitrobenzylidene)amine, (2,6-dichlorobenzylidene)-(4-fluorophenyl)-amine, and (2,6-dichlorobenzylidene)-(3 fluorophenyl)amine (NI in the range 91-96%).