Bis(4-methoxyphenyl)methyl thioether | 98466-36-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Bis(4-methoxyphenyl)methyl thioether
• 英文别名: 1-[Bis(4-methoxyphenyl)methylsulfanyl-(4-methoxyphenyl)methyl]-4-methoxybenzene
• CAS: 98466-36-5
• 化学式: C₃₀H₃₀O₄S
• 分子量: 486.632
• InChiKey: DDHSPYHTTJHAIY-UHFFFAOYSA-N

物化性质

• 沸点：
  617.2±55.0 °C(Predicted)
• 密度：
  1.156±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  62.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4,4'-二甲氧基硫代二苯甲酮 在 1-苯甲基-1,4-二氢烟酰胺 、 bis(trifluoroacetato)-1,2-phenylenedimercury 作用下， 以 乙腈 为溶剂， 反应 0.25h， 以41%的产率得到4,4-二甲氧基二苯基甲烷
  参考文献：
  名称：

  Multidentate Lewis acids. Reduction of thioketones in the presence of organomercury trifluoroacetates

  摘要：

  DOI：

  10.1021/ja00307a058

文献信息

• Therapeutic agents useful for treating or preventing pain
  申请人：——

  公开号：US20040006091A1

  公开（公告）日：2004-01-08

  A compound of formula: 1 (wherein X is O or S and R 1 , R 3 , R 4 , and R 5 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Thiadiazolylpiperazine Compound”), pharmaceutical compositions comprising a Thiadiazolylpiperazine Compound, and methods for treating or preventing pain in a patient comprising administering to a patient in need thereof an effective amount of a Thiadiazolylpiperazine Compound are disclosed.

  该化合物的化学式为：1（其中X为O或S，R1、R3、R4和R5在此披露）或其药用盐（“噻二唑基哌嗪化合物”），包括噻二唑基哌嗪化合物的药物组合物，以及治疗或预防患者疼痛的方法，包括向需要的患者给予有效剂量的噻二唑基哌嗪化合物。
• [EN] THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN<br/>[FR] AGENTS THERAPEUTIQUES UTILES POUR TRAITER LA DOULEUR
  申请人：EURO CELTIQUE SA

  公开号：WO2005012287A1

  公开（公告）日：2005-02-10

  Compounds of formulae (I) and (II) where X is S or O and Ar2, R1, R2, R3, R8, n, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a '3-substituted Pyridyl Compound'), compositions comprising an effective amount of a 3-substituted Pyridyl Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a 3-substituted Pyridyl Compound are disclosed herein.

  本文披露了式(I)和(II)的化合物，其中X为S或O，Ar2，R1，R2，R3，R8，n，m和t，或其药学上可接受的盐（“3-取代吡啶化合物”），包含有效量的3-取代吡啶化合物的组合物，以及治疗或预防疼痛，尿失禁，溃疡，炎症性肠病，易怒性肠综合征，成瘾障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症，精神病，认知障碍，记忆力缺陷，大脑功能受限，亨廷顿舞蹈症，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症的动物的方法，包括向需要治疗的动物中施用有效量的3-取代吡啶化合物。
• POLY(ORGANOPHOSPHAZENE) COMPOSITION FOR BIOMATERIALS
  申请人：SONG Soo-Chang

  公开号：US20130004455A1

  公开（公告）日：2013-01-03

  Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.

  提供了一种用于生物材料的化学交联可用的聚（有机磷氮烷）的用途，与生理活性物质共价结合的化学交联聚（有机磷氮烷），以及其用于生物材料的用途，以及制备这些材料的过程。这种化学交联可以通过紫外辐射、交联剂、添加剂、酶、至少一种聚合物的混合等方法实现。
• Method for modification of recombinant polypeptides
  申请人：BIONEBRASKA, INC.

  公开号：EP1170300A1

  公开（公告）日：2002-01-09

  The present invention provides for a method of preparing a modified recombinantly produced polypeptide including a reactive side chain group and a modified N-terminal α-amine group or C-terminal α-carboxyl group, the method comprising the steps of recombinantly forming a polypeptide having a biologically added protecting group on an N-terminal α-amine group or C-terminal α-carboxyl group, cleaving the biologically added protecting group with a cleavage reagent to form the unprotected terminal amino acid α-carbon reactive group and modifying the unprotected terminal amino acid α-carbon reactive group with a chemical modifying agent to form a terminally modified polypeptide. The invention further provides for a biologically added protecting group for a recombinantly produced polypeptide comprising a peptide or amino acid, said biologically protecting group being stable under conditions for chemical protecting reactions and including an enzymatic cleavage recognition site and a chemical cleavage recognition site, wherein the recognition sites are not present in the recombinantly produced polypeptide.

  本发明提供了一种制备修饰的重组生产的多肽的方法，该多肽包括活性侧链基团和修饰的N-末端α-氨基或C-末端α-羧基，该方法包括以下步骤 重组形成在N-末端α-氨基或C-末端α-羧基上具有生物学添加保护基团的多肽、用裂解试剂裂解生物添加的保护基团，以形成未受保护的末端氨基酸 α-碳活性基团，并用化学修饰剂修饰未受保护的末端氨基酸 α-碳活性基团，以形成末端修饰的多肽。本发明进一步提供了一种用于重组生产的多肽的生物添加保护基团，该多肽包括肽或氨基酸，所述生物保护基团在化学保护反应条件下稳定，包括酶裂解识别位点和化学裂解识别位点，其中识别位点不存在于重组生产的多肽中。
• Therapeutic agents useful for treating pain
  申请人：EURO-CELTIQUE S.A.

  公开号：EP1942106A1

  公开（公告）日：2008-07-09

  Compounds of formulae (I) and (II) where X is S or O and Ar2, R1, R2, R3, R8 n, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a "3-substituted Pyridyl Compound"), compositions comprising an effective amount of a 3-substituted Pyridyl Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a 3-substituted Pyridyl Compound are disclosed herein.

  本文公开了式(I)和(II)化合物，其中 X 为 S 或 O，Ar2、R1、R2、R3、R8 n、m 和 t 为其或其药学上可接受的盐（"3-取代吡啶基化合物"）、包含有效量 3-取代吡啶基化合物的组合物，以及治疗或预防疼痛、尿失禁、溃疡、炎症性肠病、肠易激综合征、成瘾性疾病、帕金森病、焦虑症、癫痫、帕金森病、帕金森病、帕金森病、帕金森病、帕金森病、帕金森病、帕金森病、帕金森病、帕金森病、帕金森病、帕金森病、帕金森病、帕金森病帕金森病、焦虑症、癫痫、中风、癫痫发作、瘙痒症、精神病、认知障碍、记忆缺陷、脑功能受限、亨廷顿舞蹈症、肌萎缩性脊髓侧索硬化症、痴呆症、视网膜病变、肌肉痉挛、偏头痛、呕吐、运动障碍或动物抑郁症的方法，包括向有需要的动物施用有效量的 3-取代吡啶基化合物。