6-phenylthio-2,4-bis(benzamido)pyrimidine | 1190622-67-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 6-phenylthio-2,4-bis(benzamido)pyrimidine
• 英文别名: N-(2-benzamido-6-phenylsulfanylpyrimidin-4-yl)benzamide
• CAS: 1190622-67-3
• 化学式: C₂₄H₁₈N₄O₂S
• 分子量: 426.499
• InChiKey: KZNRUOYERIHUPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,4-dichloro-6-(phenylthio)pyrimidine 、 苯甲酰胺 在 吡啶 作用下， 以 甲醇 为溶剂， 以50%的产率得到6-phenylthio-2,4-bis(benzamido)pyrimidine
  参考文献：
  名称：

  新型 6-苯基硫代-2,4- 取代嘧啶的高效合成

  摘要：

  6-苯硫基-2,4-二取代嘧啶从巴比妥酸开始，分五步制备。巴比妥酸与 POCl 3 在 N，V-二甲基苯胺存在下的反应提供 2,4,6-三氯嘧啶，其与水溶液反应。NaOH回流产生6-氯尿嘧啶。6-氯尿嘧啶与苯硫酚在碱性条件下反应得到6-苯基硫尿嘧啶，在回流下使用过量POCl 3 氯化得到关键合成子6-苯硫基2,4-二氯嘧啶。6-苯硫基2,4-二氯嘧啶与氧亲核试剂如苄酸钠和氮亲核试剂如杂环伯胺、脂肪族伯胺和取代的芳香伯胺的芳香亲核取代反应提供了目标化合物6-苯硫基，4-二取代的嘧啶分别以 40-80% 的产率得到。介绍 在过去几年中，Ce 位取代的尿嘧啶和嘧啶酮类似物已成为化疗领域潜在的抗病毒药物。在重要的 6-取代尿嘧啶衍生物中，1-[(2-羟乙基)甲基]-6苯基硫尿嘧啶 (HEPT) 及其类似物 6-苄基-1-(乙氧基甲基)-5-异丙基尿嘧啶 (Emivirine, EMV) 已被选为治疗获得性免疫缺陷病毒

  DOI：

  10.1515/hc.2008.14.6.443

文献信息

• POLYMER FILM, RETARDATION FILM, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY, AND COMPOUND
  申请人：FUJIFILM Corporation

  公开号：US20160159750A1

  公开（公告）日：2016-06-09

  Provided is a polymer film containing at least one of a compound represented by formula (1) of hydrates, solvates, or salts thereof. Y is a methine group or nitrogen atom. Q a , Q b , and Q c are a single bond or a divalent linking group. R a , R b , and R c , are hydrogen atom, alkyl group, alkenyl group, alkynyl group, aryl group, cyano group, halogen group, or heterocyclic group. X 2 is a single bond or a divalent linking group. X 1 is a single bond or a predetermined divalent linking group. R 1 and R 2 are a hydrogen atom, alkyl group, alkenyl group, alkynyl group, aryl group, or heterocyclic group Formula (1)

  提供的是一种聚合物薄膜，其中至少包含一种由式（1）表示的化合物的水合物、溶剂合物或盐类。Y是一个亚甲基基团或氮原子。Qa、Qb和Qc是单键或二价连接基团。Ra、Rb和Rc是氢原子、烷基基团、烯基基团、炔基基团、芳基、氰基、卤素基或杂环基。X2是单键或二价连接基团。X1是单键或预定的二价连接基团。R1和R2是氢原子、烷基基团、烯基基团、炔基基团、芳基或杂环基。Formula (1)
• CELLULOSE ACYLATE FILM, RETARDATION FILM, POLARIZER AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：NAGURA MASATO

  公开号：US20110076423A1

  公开（公告）日：2011-03-31

  A cellulose acylate film comprising a cellulose acylate resin satisfying the formulae (i)-(iii) and a compound capable of forming a hydrogen bond satisfying conditions (A)-(C): (A) the compound has both a hydrogen bond donor moiety and a hydrogen bond acceptor moiety in the molecule, (B) the value obtained by dividing the molecular weight of the compound by the total of the number of the hydrogen bond donor moiety and the number of the hydrogen bond acceptor moiety is from 30 to 65, (C) the number of aromatic ring structures is from 1 to 3, 0.5≦ A+B ≦2.7,  (i) 0.0≦A≦2.5, and  (ii) 0.1≦B≦2.0,  (iii) wherein A means the degree of substitution with an acetyl group, and B means a total of the degree of substitution with a propionyl group and the degree of substitution with a butyryl group.
• Optical film, retardation film, polarizing plate, and liquid crystal display device
  申请人：Sasada Yasuyuki

  公开号：US20120018685A1

  公开（公告）日：2012-01-26

  An optical film contains a cellulose ester and more than 30% by mass, relative to the cellulose ester, of a condensation product of at least one polyhydric alcohol having an average of 2.01 or more carbon atoms and at least one polybasic acid having an average of 4.10 or more carbon atoms, and at least one of the at least one polyhydric alcohol contains at least three carbon atoms bonded together without being interrupted by any other atom.
• Cellulose Acylate Film, Retardation Film, Polarizer and Liquid Crystal Display Device
  申请人：Nagura Masato

  公开号：US20120204757A1

  公开（公告）日：2012-08-16

  A cellulose acylate film comprising a cellulose acylate resin satisfying the formulae (i)-(iii) and a compound capable of forming a hydrogen bond satisfying conditions (A)-(C): (A) the compound has both a hydrogen bond donor moiety and a hydrogen bond acceptor moiety in the molecule, (B) the value obtained by dividing the molecular weight of the compound by the total of the number of the hydrogen bond donor moiety and the number of the hydrogen bond acceptor moiety is from 30 to 65, (C) the number of aromatic ring structures is from 1 to 3, 0.5≦ A+B ≦2.7,  (i) 0.0≦ A ≦2.5, and  (ii) 0.1≦ B ≦2.0,  (iii) wherein A means the degree of substitution with an acetyl group, and B means a total of the degree of substitution with a propionyl group and the degree of substitution with a butyryl group.
• OPTICAL FILM, PHASE DIFFERENCE FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：SASADA Yasuyuki

  公开号：US20120231217A1

  公开（公告）日：2012-09-13

  An optical film, including: an additive; a wax component; and a cellulose ester, wherein the optical film satisfies the following equations (1) and (2): Equation (1): |ΔC/Ct|≧0.1×(Ct/d−0.3) and Equation (2): Ct/d≧0.375; wherein Ct represents a total content of the additive whose unit is % by mass, d represents a film thickness whose unit is μm, and ΔC is represented by Ct−Cs; wherein Cs represents a surface content of the additive in at least one side of the optical film.