1-(4-Butoxy-benzenesulfonyl)-pyrrolidin-3-ol | 392231-75-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-Butoxy-benzenesulfonyl)-pyrrolidin-3-ol
• 英文别名: 1-(4-butoxyphenyl)sulfonylpyrrolidin-3-ol
• CAS: 392231-75-3
• 化学式: C₁₄H₂₁NO₄S
• 分子量: 299.391
• InChiKey: QQHDCXHZEFHIOC-UHFFFAOYSA-N

物化性质

• 沸点：
  460.7±55.0 °C(Predicted)
• 密度：
  1.260±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  75.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(4-Butoxy-benzenesulfonyl)-pyrrolidin-3-ol 在 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 生成 (S)-1-{Benzyl-[1-(4-butoxy-benzenesulfonyl)-pyrrolidin-3-yl]-amino}-3-(9H-carbazol-4-yloxy)-propan-2-ol
  参考文献：
  名称：

  Cyclic amine sulfonamides as linkers in the design and synthesis of novel human β3 adrenergic receptor agonists

  摘要：

  Piperidine, pyrrolidine, and azetidine sulfonamides were examined as linkers in designing novel human beta(3) adrenergic receptor (beta(3)-AR) agonists. The azetidine derivative 37, and piperidine derivatives 7, 8, and 13 were found to be potent beta(3)-AR agonists and have good selectivity against beta(1)- and beta(2)-AR. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00387-1
• 作为产物：
  描述：

  3-羟基吡咯烷 、 4-正丁氧基苯磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 1-(4-Butoxy-benzenesulfonyl)-pyrrolidin-3-ol
  参考文献：
  名称：

  Cyclic amine sulfonamides as linkers in the design and synthesis of novel human β3 adrenergic receptor agonists

  摘要：

  Piperidine, pyrrolidine, and azetidine sulfonamides were examined as linkers in designing novel human beta(3) adrenergic receptor (beta(3)-AR) agonists. The azetidine derivative 37, and piperidine derivatives 7, 8, and 13 were found to be potent beta(3)-AR agonists and have good selectivity against beta(1)- and beta(2)-AR. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00387-1

文献信息

• Cyclamine sulfonamides as beta-3 adrenergic receptor agonists
  申请人：American Home Products Corporation

  公开号：US20020022605A1

  公开（公告）日：2002-02-21

  This invention provides compounds of Formula I having the structure 1 wherein R 1 , R 2 , R 3 , W, X, and Z are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

  本发明提供了具有结构1的化合物，其中R1、R2、R3、W、X和Z如前所定义，或其药学上可接受的盐，这些化合物可用于治疗与胰岛素抵抗或高血糖相关的代谢性疾病。
• Cyclylamine sulfonamides as beta-3 adrenergic receptor agonists
  申请人：Wyeth

  公开号：US20030027797A1

  公开（公告）日：2003-02-06

  This invention provides compounds of Formula I having the structure 1 wherein R 1 , R 2 , R 3 , W, X, and Z are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

  本发明提供具有结构1的化合物，其中R1，R2，R3，W，X和Z如前所定义，或其药学上可接受的盐，用于治疗与胰岛素抵抗或高血糖相关的代谢性疾病。
• Cyclylamine sulfonamides as &bgr;3-adrenergic receptor agonists
  申请人：Wyeth

  公开号：US06649603B2

  公开（公告）日：2003-11-18

  This invention provides compounds of Formula I having the structure wherein R1, R2, R3, W, X, and Z are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

  这项发明提供了I式化合物，其结构为R1，R2，R3，W，X和Z如前所定义，或其药学上可接受的盐，用于治疗与胰岛素抵抗或高血糖相关的代谢性疾病。
• Cyclamine sulfonamides as &bgr;-3 adrenergic receptor agonists
  申请人：Wyeth

  公开号：US06498170B2

  公开（公告）日：2002-12-24

  This invention provides compounds of Formula I having the structure wherein R1, R2, R3, W, X, and Z are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

  该发明提供了一种具有公式I结构的化合物，其中R1、R2、R3、W、X和Z如前所定义，或其药学上可接受的盐，用于治疗与胰岛素抵抗或高血糖相关的代谢性疾病。
• CYCLYLAMINE SULFONAMIDES AS BETA-3 ADRENERGIC RECEPTOR AGONISTS
  申请人：Wyeth

  公开号：EP1328512A2

  公开（公告）日：2003-07-23