4,4'-(((bis(2-methoxyphenyl)silanediyl)bis(oxy))bis(ethane-2,1-diyl))diphenol | 1394170-67-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4,4'-(((bis(2-methoxyphenyl)silanediyl)bis(oxy))bis(ethane-2,1-diyl))diphenol
• 英文别名: 4-[2-[2-(4-Hydroxyphenyl)ethoxy-bis(2-methoxyphenyl)silyl]oxyethyl]phenol；4-[2-[2-(4-hydroxyphenyl)ethoxy-bis(2-methoxyphenyl)silyl]oxyethyl]phenol
• CAS: 1394170-67-2
• 化学式: C₃₀H₃₂O₆Si
• 分子量: 516.666
• InChiKey: DBAIQVJJLQGSLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.19
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  77.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  六氟异丙醇 、 4,4'-(((bis(2-methoxyphenyl)silanediyl)bis(oxy))bis(ethane-2,1-diyl))diphenol 在 碘苯二乙酸 作用下， 反应 0.02h， 生成
  参考文献：
  名称：

  Oxidative ipso-Rearrangement Performed by a Hypervalent Iodine Reagent and Its Application

  摘要：

  An oxidative ipso-rearrangement mediated by a hypervalent iodine reagent that enables rapid generation of a functionalized dienone system containing a quaternary carbon center connected to several sp(2) centers has been developed. The process occurs through transfer of an aryl group from a silyl segment present on the lateral chain. As an illustration of the potential of this transformation, a total synthesis of sceletenone, a small alkaloid, is described.

  DOI：

  10.1021/jo301408j
• 作为产物：
  描述：

  2-(4{[tert-butyl(dimethyl)silyl]oxy}phenyl)ethanol 在 咪唑 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.08h， 生成 4,4'-(((bis(2-methoxyphenyl)silanediyl)bis(oxy))bis(ethane-2,1-diyl))diphenol
  参考文献：
  名称：

  Oxidative ipso-Rearrangement Performed by a Hypervalent Iodine Reagent and Its Application

  摘要：

  An oxidative ipso-rearrangement mediated by a hypervalent iodine reagent that enables rapid generation of a functionalized dienone system containing a quaternary carbon center connected to several sp(2) centers has been developed. The process occurs through transfer of an aryl group from a silyl segment present on the lateral chain. As an illustration of the potential of this transformation, a total synthesis of sceletenone, a small alkaloid, is described.

  DOI：

  10.1021/jo301408j

文献信息

• Oxidative <i>ipso</i>-Rearrangement Performed by a Hypervalent Iodine Reagent and Its Application
  作者：Guillaume Jacquemot、Sylvain Canesi

  DOI：10.1021/jo301408j

  日期：2012.9.7

  An oxidative ipso-rearrangement mediated by a hypervalent iodine reagent that enables rapid generation of a functionalized dienone system containing a quaternary carbon center connected to several sp(2) centers has been developed. The process occurs through transfer of an aryl group from a silyl segment present on the lateral chain. As an illustration of the potential of this transformation, a total synthesis of sceletenone, a small alkaloid, is described.