1,2-dimethyl-1,2,3,4-tetrahydroquinazolin-4-one | 60868-25-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,2-dimethyl-1,2,3,4-tetrahydroquinazolin-4-one
• 英文别名: 1,2-Dimethyl-2,3-dihydro-chinazolon-(4)；2,3-Dihydro-1,2-dimethyl-chinazol-4-on；2,3-Dihydro-1,2-dimethyl-chinazolon-(4)；1,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one；1,2-Dimethyl-4(3h)-quinazolinone；1,2-dimethyl-2,3-dihydroquinazolin-4-one
• CAS: 60868-25-9
• 化学式: C₁₀H₁₂N₂O
• 分子量: 176.218
• InChiKey: ILAGIUMQYBZMSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2-dimethyl-1,2,3,4-tetrahydroquinazolin-4-one 、 乙酸酐 在 吡啶 作用下， 反应 3.0h， 以97%的产率得到3-acetyl-1,2-dimethyl-1,2,3,4-tetrahydroquinazolin-4-one
  参考文献：
  名称：

  Yamato, Masatoshi; Horiuchi, Jiroh; Takeuchi, Yasuo, Chemical and pharmaceutical bulletin, 1981, vol. 29, # 10, p. 3055 - 3059

  摘要：

  DOI：
• 作为产物：
  描述：

  Glomerin 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以60%的产率得到1,2-dimethyl-1,2,3,4-tetrahydroquinazolin-4-one
  参考文献：
  名称：

  Yamato, Masatoshi; Horiuchi, Jiroh; Takeuchi, Yasuo, Chemical and pharmaceutical bulletin, 1981, vol. 29, # 10, p. 3055 - 3059

  摘要：

  DOI：

文献信息

• YAMATO, MASATOSHI;HORIUCHI, JIROH;TAKEUCHI, YASUO, CHEM. AND PHARM. BULL., 1981, 29, N 10, 3055-3059
  作者：YAMATO, MASATOSHI、HORIUCHI, JIROH、TAKEUCHI, YASUO

  DOI：——

  日期：——
• HORIUCHI, JIROH;TAKEUCHI, YASUO;YAMATO, MASATOSHI, CHEM. AND PHARM. BULL., 1981, 29, N 11, 3130-3133
  作者：HORIUCHI, JIROH、TAKEUCHI, YASUO、YAMATO, MASATOSHI

  DOI：——

  日期：——
• NITROGEN-CONTAINING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF ATRIAL FIBRILLATION
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：EP2467364A2

  公开（公告）日：2012-06-27
• [EN] NITROGEN-CONTAINING COMPOUND AND PHARMACEUTICAL COMPOSITION<br/>[FR] COMPOSÉ CONTENANT DE L'AZOTE ET COMPOSITION PHARMACEUTIQUE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2011021726A2

  公开（公告）日：2011-02-24

  The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently -N= or -CH=; and R5 is group represented by (2) wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group -XA-N-XB-; XA and XB are each independently a bond, lower alkylene, etc.
• Yamato, Masatoshi; Horiuchi, Jiroh; Takeuchi, Yasuo, Chemical and pharmaceutical bulletin, 1981, vol. 29, # 10, p. 3055 - 3059
  作者：Yamato, Masatoshi、Horiuchi, Jiroh、Takeuchi, Yasuo

  DOI：——

  日期：——