2-羟基异烟酸N-氧化物 | 119736-22-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-羟基异烟酸N-氧化物
• 中文别名: 1-羟基-2-氧代-1,2-二氢-4-吡啶羧酸
• 英文名称: 2-Hydroxyisonicotinic acid N-oxide
• 英文别名: 1-hydroxy-2-oxopyridine-4-carboxylic acid
• CAS: 119736-22-0；13602-64-7
• 化学式: C₆H₅NO₄
• 分子量: 155.11
• InChiKey: JFXSGPUFCQCCQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• ENHANCED STABILITY OF ZINC PYRITHIONE IN OXIDATIVE ENVIRONMENTS, SUCH AS SCALP SEBACEOUS FLUID
  申请人：The Procter & Gamble Company

  公开号：US20200405600A1

  公开（公告）日：2020-12-31

  The present invention discloses a personal care composition comprising: (a) A polyvalent metal salt of pyrithione; (b) A metal complex selected from the group consisting of: wherein Y 1 , Y 2 , Z 1 , Z 2 are selected from the following groups: —NH 2 , —NHR 11 , —NR 12 R 12 , —NHCO—R 20 , —SH, —OR 13 , —O(C═O)—, phosphate. and wherein at least one of Y 1 and Z 1 of compound I is —SH, and wherein at least one of Y 2 and Z 2 of compound II is —SH R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , can independently be H, alkyl, substituted alkyl, phenyl, aryl; R 14 is —NH 2 , —NHCO—CH 3 , —NHR 17 , or —NR 18 R 18 R 15 is —COOH, —COOR 19 R 11 , R 12 , R 13 R 16 , R 17 , R 18 , R 19 can be independently be alkyl, substituted alkyl, phenyl, aryl. and wherein the metal of the complex is selected from the group consisting of zinc, copper, and iron.

  本发明公开了一种个人护理组合物，包括：（a）吡咯硫酮的多价金属盐；（b）从以下组中选择的金属配合物：其中Y1、Y2、Z1、Z2从以下组中选择：—NH2、—NHR11、—NR12R12、—NHCO—R20、—SH、—OR13、—O(C═O)—、磷酸盐。其中化合物I的Y1和Z1中至少一个是—SH，化合物II的Y2和Z2中至少一个是—SH。R1、R2、R3、R4、R5、R6、R7、R8、R9、R10可以独立地是H、烷基、取代烷基、苯基、芳基；R14是—NH2、—NHCO—CH3、—NHR17或—NR18R18；R15是—COOH、—COOR19；R11、R12、R13、R16、R17、R18、R19可以独立地是烷基、取代烷基、苯基、芳基。配合物的金属来自锌、铜和铁。
• Solid concentrate compositions containing zinc pyrithione
  申请人：The Procter & Gamble Company

  公开号：US10450537B2

  公开（公告）日：2019-10-22

  The present invention relates to a solid concentrate composition comprising: (a) from 5% to 25% by weight of zinc pyrithione (ZPT); (b) from 8% to 85% by weight of at least one surfactant, preferably, wherein the solid concentrate composition has a penetration hardness of between 20 N and 50 N according to the test method as disclosed herein.

  本发明涉及一种固体浓缩物组合物，该组合物包含：(a) 5%至 25%（按重量计）的吡硫锌（ZPT）；(b) 8%至 85%（按重量计）的至少一种表面活性剂，其中固体浓缩物组合物根据本文公开的测试方法具有 20 N 至 50 N 的渗透硬度。
• Method of treating a hair disorder with N-hydroxypyridinones
  申请人：The Procter & Gamble Company

  公开号：US10543157B2

  公开（公告）日：2020-01-28

  The present invention is directed to a method for treating a hair disorder in a human or animal in need thereof, involving topically applying to the human or animal an effective amount of at least one 6-substituted 2-pyridinol N-oxide compound, a tautomer, or a cosmetically acceptable salt thereof wherein a hair count is increased by at least 0.5 hairs/cm2 and/or an increase the number of anagen hairs and maintain the number of telogen hairs when compared to a baseline and/or vehicle.

  本发明涉及一种治疗有需要的人或动物毛发疾病的方法，该方法涉及向人或动物局部施用有效量的至少一种 6-取代的 2-吡啶醇 N-氧化物化合物、其同系物或其美容上可接受的盐，与基线和/或载体相比，毛发数量至少增加 0.5 根/平方厘米和/或增加生长期毛发的数量并保持休止期毛发的数量。
• 2-pyridinol-N-oxide deodorant and antiperspirant compositions
  申请人：The Procter & Gamble Company

  公开号：US10555884B2

  公开（公告）日：2020-02-11

  A deodorant stick having a substituted or unsubstituted 2-pyridinol-N-oxide material and at least one material selected from the group consisting of hexamidine, magnesium carbonate, zinc carbonate, thymol, magnesium hydroxide, dead sea salt, calcium carbonate, polyvinyl formate, salycilic acid, niacinamide, and combinations thereof.

  一种除臭棒，具有取代或未取代的 2-吡啶醇-N-氧化物材料和至少一种选自以下组别的材料：己脒、碳酸镁、碳酸锌、百里酚、氢氧化镁、死海盐、碳酸钙、甲酸聚乙烯酯、水杨酸、烟酰胺及其组合。
• Antifoam molecules containing a silica moiety and compositions
  申请人：The Procter & Gamble Company

  公开号：US10611987B2

  公开（公告）日：2020-04-07

  The present application relates to cleaning and treatment compositions comprising a material that reduces foam and methods of making and using such material and compositions. Such compositions comprise benefit agents that typically impact the performance of antifoams yet in the present compositions antifoaming properties of antifoams are maintained.

  本申请涉及包含可减少泡沫的材料的清洁和处理组合物，以及制造和使用这种材料和组合物的方法。此类组合物包含通常会影响消泡剂性能的助剂，但在本组合物中，消泡剂的消泡特性得以保持。