[EN] PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BENZIMIDAZOLECARBOXYLIC ACIDS [FR] PROCÉDÉ ET INTERMÉDIAIRES POUR LA PRÉPARATION D'ACIDES BENZIMIDAZOLECARBOXYLIQUES
[EN] PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BENZIMIDAZOLECARBOXYLIC ACIDS<br/>[FR] PROCÉDÉ ET INTERMÉDIAIRES POUR LA PRÉPARATION D'ACIDES BENZIMIDAZOLECARBOXYLIQUES
申请人:LONZA AG
公开号:WO2010149359A1
公开(公告)日:2010-12-29
Substituted benzimidazolecarboxylic acids of formula (I), wherein R1 and R2 independently are hydrogen, C1-6 alkyl or C3-6 cycloalkyl, are prepared in a four-step synthesis starting from N-acyl-4-haloanilines of formula (II), wherein R1 is as defined above, R3 is C1-4 alkyl and X is chlorine or bromine.
[EN] PROCESS FOR THE PREPARATION OF BENZIMIDAZOLES<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION DE BENZIMIDAZOLES
申请人:LONZA AG
公开号:WO2010149360A1
公开(公告)日:2010-12-29
Substituted benzimidazoles of formula (I), wherein R1 and R2 independently are hydrogen, C1-6 alkyl or C3-6 cycloalkyl and R3 is cyano or carboxy, are prepared in a multistep synthesis starting from Ν-acyl-4-halo- anilines of formula (II), wherein R1 and R2 are as defined above and X is chlorine or bromine.