2-羟基苯甲酸 8-喹啉基酯 | 42206-69-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-羟基苯甲酸 8-喹啉基酯
• 中文别名: 2-羟基苯甲酸8-喹啉基酯
• 英文名称: salicylic acid-[8]quinolyl ester
• 英文别名: Salicylsaeure-[8]chinolylester；Oxyquinoline salicylate ester；quinolin-8-yl 2-hydroxybenzoate
• CAS: 42206-69-9
• 化学式: C₁₆H₁₁NO₃
• 分子量: 265.268
• InChiKey: CLIMZDIZFXRPCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(quinolin-8-oxy)-benzoic acid 在 核黄素,2',3',4',5'-四乙酸酯 、 potassium carbonate 作用下， 以 水 、 乙腈 为溶剂， 以73 %的产率得到2-羟基苯甲酸 8-喹啉基酯
  参考文献：
  名称：

  水中维生素 B2 衍生光催化剂的激进微笑重排

  摘要：

  在此，我们报道了一种芳烃从乙醚迁移到羧酸的催化自由基-Smiles重排系统，以核黄素四乙酸酯（RFT）（一种容易获得的天然维生素B2酯）为光催化剂，以水为绿色溶剂，不含外部氧化剂、碱、金属、惰性气体保护、反应时间长。不仅是已知的取代的2-苯氧基苯甲酸底物，而且一组基于萘和杂环的类似物首次被转化为相应的芳基水杨酸酯。机理研究，特别是一些动力学同位素效应（KIE）实验，表明双功能黄素光催化剂能够实现连续的电子转移-质子转移过程。

  DOI：

  10.1021/acs.joc.3c02762

文献信息

• DE281007
  申请人：——

  公开号：——

  公开（公告）日：——
• BALICA, GHEORGHE;NOGOMIROANU, TOMA;BALICA, GELU MARIUS;SPETEANU, ROZALIA;+
  作者：BALICA, GHEORGHE、NOGOMIROANU, TOMA、BALICA, GELU MARIUS、SPETEANU, ROZALIA、+

  DOI：——

  日期：——
• PROTEASOME INHIBITORS AND USES THEREOF
  申请人：Lavelin Irina

  公开号：US20120083477A1

  公开（公告）日：2012-04-05

  A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.
• ANTIMICROBIAL COMPOSITIONS
  申请人：THE PISCES GROUP LLC

  公开号：US20140179645A1

  公开（公告）日：2014-06-26

  Described herein are antimicrobial compositions, methods of making thereof, a kit comprising said compositions, and methods for removing microorganisms from surfaces by using said compositions. In one aspect, the antimicrobial composition is a kit composed of a first composition that comprises a dissolved metal salt and a second composition that comprises a ligand, wherein the ligand comprises (i) a residue of antibacterial agent and (ii) a residue of an antifungal agent, wherein the antibacterial agent and/or antifungal agent comprises at least one aryl group. These compositions can further comprise (a) surfactants and/or emulsifiers, (b) thickeners, and (c) solvents or carriers such as water, propylene glycol, and glycerin. In some aspects, these compositions can also comprise fragrances, humectants, emollients, essential oils, plant extracts, and other natural products. Optional additives that are known in the art may also be included.
• US3944669A
  申请人：——

  公开号：US3944669A

  公开（公告）日：1976-03-16