2-Phenylsulfanyl-hept-6-enoic acid methyl ester | 196494-62-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-Phenylsulfanyl-hept-6-enoic acid methyl ester
• 英文别名: Methyl 2-phenylsulfanylhept-6-enoate；methyl 2-phenylsulfanylhept-6-enoate
• CAS: 196494-62-9
• 化学式: C₁₄H₁₈O₂S
• 分子量: 250.362
• InChiKey: VVWZRBJKILIALY-UHFFFAOYSA-N

物化性质

• 沸点：
  349.6±42.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Phenylsulfanyl-hept-6-enoic acid methyl ester 在 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 苯 为溶剂， 生成 6-庚酸甲酯 、 methyl trans-2-methylcyclopentanecarboxylate 、 (+/-)-cis-1-carbomethoxy-2-methylcyclopentane
  参考文献：
  名称：

  A Model Study of Intramolecular Asymmetric Radical Cyclizations of α-Ester and α-Amide Radicals

  摘要：

  AbstractStarting from malonate, a practical route was developed for the synthesis of α‐phenylthio acid 3. Several chiral compounds including (‐)‐menthol, (‐)‐8‐pbenylmenthol and a camphor based oxazolidinone 8 reacted with 3 to give α‐phenylthio esters or amide. These sulfides cyclized efficiently when reacted with tributyltin hydride. Among the chiral auxiliaries used, 8‐phenylmenthyl group displayed moderate asymmetric induction (64% ee for cis‐product and 40% ee for trans‐product). Based on this results, a transition state model was proposed to explain the observed stereoselectivity. In this model, due to π,π‐orbital overlap of the phenyl ring and the carbonyl, the si‐face of the most stable conformer of the radical was shielded. This controlled the carbon‐carbon bond formation to occur from the re‐face.

  DOI：

  10.1002/jccs.199700039
• 作为产物：
  描述：

  1-苯硫基-吡咯啉-2,5-二酮 在 4-二甲氨基吡啶 、 氢氧化钾 、 sodium hydride 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 17.0h， 生成 2-Phenylsulfanyl-hept-6-enoic acid methyl ester
  参考文献：
  名称：

  A Model Study of Intramolecular Asymmetric Radical Cyclizations of α-Ester and α-Amide Radicals

  摘要：

  AbstractStarting from malonate, a practical route was developed for the synthesis of α‐phenylthio acid 3. Several chiral compounds including (‐)‐menthol, (‐)‐8‐pbenylmenthol and a camphor based oxazolidinone 8 reacted with 3 to give α‐phenylthio esters or amide. These sulfides cyclized efficiently when reacted with tributyltin hydride. Among the chiral auxiliaries used, 8‐phenylmenthyl group displayed moderate asymmetric induction (64% ee for cis‐product and 40% ee for trans‐product). Based on this results, a transition state model was proposed to explain the observed stereoselectivity. In this model, due to π,π‐orbital overlap of the phenyl ring and the carbonyl, the si‐face of the most stable conformer of the radical was shielded. This controlled the carbon‐carbon bond formation to occur from the re‐face.

  DOI：

  10.1002/jccs.199700039

文献信息

• A Model Study of Intramolecular Asymmetric Radical Cyclizations of α-Ester and α-Amide Radicals
  作者：Ru-Long Yeh、Weir-Tom Jiaang、Yeun-Min Tsai

  DOI：10.1002/jccs.199700039

  日期：1997.6

  AbstractStarting from malonate, a practical route was developed for the synthesis of α‐phenylthio acid 3. Several chiral compounds including (‐)‐menthol, (‐)‐8‐pbenylmenthol and a camphor based oxazolidinone 8 reacted with 3 to give α‐phenylthio esters or amide. These sulfides cyclized efficiently when reacted with tributyltin hydride. Among the chiral auxiliaries used, 8‐phenylmenthyl group displayed moderate asymmetric induction (64% ee for cis‐product and 40% ee for trans‐product). Based on this results, a transition state model was proposed to explain the observed stereoselectivity. In this model, due to π,π‐orbital overlap of the phenyl ring and the carbonyl, the si‐face of the most stable conformer of the radical was shielded. This controlled the carbon‐carbon bond formation to occur from the re‐face.