N, N-di-n-hexylbenzene-1,4-diamine | 85968-19-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N, N-di-n-hexylbenzene-1,4-diamine
• 英文别名: N,N-di-n-hexylbenzene-1,4-diamine；N,N-di-n-hexylbenzene1,4-diamine；4-N,4-N-dihexylbenzene-1,4-diamine
• CAS: 85968-19-0
• 化学式: C₁₈H₃₂N₂
• 分子量: 276.465
• InChiKey: UHSCXIFUNLHHAB-UHFFFAOYSA-N

物化性质

• 沸点：
  400.4±18.0 °C(Predicted)
• 密度：
  0.937±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N, N-di-n-hexylbenzene-1,4-diamine 在 四(三苯基膦)钯 、 正丁基锂 、 potassium tert-butylate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成
  参考文献：
  名称：

  双噻吩并[3,2- b：2'，3'- d ]吡咯（DTP）间隔基的N-杂环取代基以及敏化剂的吸附时间对芳胺有机染料的光电性能的影响†

  摘要：

  Dithieno [3,2- b：2′，3′- d具有强电子给体能力的]吡咯（DTP）化合物是光敏剂的有希望的间隔基。已经设计并合成了一系列带有N杂环取代的DTP间隔基的新型芳胺有机染料，用于无碘染料敏化太阳能电池（DSC）。已经对所有敏化剂的吸收，电化学和光电性质进行了系统研究。研究发现，掺入二己基苯胺或己基咔唑单元而不是苯单元，可以显着延迟二氧化钛-电解质界面处的电荷复合，从而改善细胞的光电流和光电压。此外，我们发现在延长从溶液中吸收染料期间的吸附时间后，效率显着提高。当染料吸附进行36小时后，与染色12小时的电池相比，在标准报告条件下测得的光伏性能参数得到了改善。还根据光收集，界面动力学参数以及它们对光伏性能的共同影响，研究了吸附时间，相关染料负载量和电子寿命的影响。受益于36个小时的染料吸收对光伏性能的有利影响，我们实现了高效的无碘DSC，在100 mW cm处测得的功率转换效率为8

  DOI：

  10.1039/c3ta12746j
• 作为产物：
  描述：

  二已胺 在 platinum on activated charcoal 氢气 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 48.0h， 生成 N, N-di-n-hexylbenzene-1,4-diamine
  参考文献：
  名称：

  Structure−Activity Relationships for the Antileishmanial and Antitrypanosomal Activities of 1‘-Substituted 9-Anilinoacridines

  摘要：

  Members of the class of 9-anilinoacridine topoisomerase II inhibitors bearing lipophilic electron-donating 1'-anilino substituents are active against both the promastigote and amastigote forms of the parasite Leishmania major. A series of analogues of the known 1'-NHhexyl lead compound were prepared and evaluated against L. major in macrophage culture to further develop structure-activity relationships (SAR). Toxicity toward mammalian cells was measured in a human leukemia cell line, and the ratio of the two IC50 values (IC50(J)/IC50(L)) was used as a measure of the in vitro therapeutic index (IVTI). A 3,6-diNMe(2) substitution pattern on the acridine greatly increased toxicity to L. major without altering mammalian toxicity, increasing IVTIs over that of the lead compound. The 2-OMe, 6-Cl acridine substitution pattern used in the antimalarial drug mepacrine also resulted in potent antileishmanial activity and high IVTIs. Earlier suggestions of the utility of 2'-OR groups in lowering mammalian cytotoxicity were not borne out in this wider study. A series of very lipophilic 1'-NRR (symmetric dialkylamino)-substituted analogues showed relatively high antileishmanial potency, but no clear trend was apparent across the series, and none were superior to the 1'-NH(CH2)(5)Me subclass. Subsets of the most active 1'-N(R)(CH2)(5)Me- and 1'-N(alkyl)(2)-substituted compounds against L. major were also evaluated against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei, but no consistent SAR could be discerned in these physiologically diverse test systems. The present study has confirmed earlier conclusions that lipophilic electron-donating groups at the 1'-position of 9-anilinoacridines provide high activity against L. major, but the SAR patterns observed do not carry over to the other parasites studied.

  DOI：

  10.1021/jm970232h

文献信息

• SYNERGISTIC LUBRICATING OIL COMPOSITION CONTAINING A MIXTURE OF A NITRO-SUBSTITUTED DIARYLAMINE AND A DAIRYLAMINE
  申请人：Cherpeck Richard E.

  公开号：US20080318815A1

  公开（公告）日：2008-12-25

  Disclosed is a lubricating oil composition containing an oil of lubricating viscosity and a particularly effective mixture of a nitro-substituted diphenylamine and a diarylamine which together provide superior oxidation inhibition.

  公开了一种润滑油组合物，包含具有润滑粘度的油和一种特别有效的硝基取代二苯胺和二芳胺混合物，二者共同提供卓越的氧化抑制作用。
• Synergistic lubricating oil composition containing a mixture of a nitro-substituted diarylamine and a diarylamine
  申请人：Chevron Oronite Company LLC

  公开号：US07683017B2

  公开（公告）日：2010-03-23

  Disclosed is a lubricating oil composition containing an oil of lubricating viscosity and a particularly effective mixture of a nitro-substituted diphenylamine and a diarylamine which together provide superior oxidation inhibition.

  公开了一种润滑油组合物，包含具有润滑黏度的油和一种特别有效的硝基取代二苯胺和二芳胺的混合物，二者共同提供卓越的氧化抑制作用。
• Reagent composition for measuring hydrogen sulfide and method for measuring hydrogen sulfide
  申请人：FUJIREBIO INC.

  公开号：EP0936466A2

  公开（公告）日：1999-08-18

  A reagent composition for measuring hydrogen sulfide, which comprises an aniline derivative represented by the general formula (I): wherein R1 and R2 independently represent a substituted or unsubstituted C2-C6 alkyl group, and R3 and R4 independently represent a hydrogen atom, a C1-C6 alkyl group or a halogen atom; and an oxidizing agent, as well as a method for measuring hydrogen sulfide in a sample using the aniline derivative represented by the general formula (I) above.

  一种测量硫化氢的试剂组合物，它包括通式(I)代表的苯胺衍生物： 其中 R1 和 R2 独立地代表取代或未取代的 C2-C6 烷基，R3 和 R4 独立地代表氢原子、C1-C6 烷基或卤素原子；和一种氧化剂，以及一种使用上述通式（I）代表的苯胺衍生物测量样品中硫化氢的方法。
• COMPOUND FOR GENERATING SECOND HARMONIC OF LIGHT, DYE COMPOSITION FOR GENERATING SECOND HARMONIC OF LIGHT, AND CELL EXAMINATION METHOD
  申请人：Keio University

  公开号：EP3000848A1

  公开（公告）日：2016-03-30

  Provided are a compound that generates an SHG signal but has suppressed generation of a TPF signal. Also provided is a cell examination method using the same. A compound for generating a second harmonic of light, the compound being an azobenzene derivative of formula (1), or a salt thereof. (R1 and R2 independently represent alkyl groups having 6-12 carbon atoms, and R3 to R18 independently represent substituents selected from hydrogen, halogens, alkyl groups, alkoxy groups, aryl groups, amino groups, hydroxyl groups, nitro groups, and cyano groups, R5 and R6, R9 and R10, R13 and R14, and R17 and R18 may combine together and form a ring structure having 5-7 carbon atoms. X represents -N+R19R20R21, a sulfonyl group, a carboxyl group, or an -OR group. Here, R19, R20, and R21 independently represent straight-chain or branched alkyl groups having 1-5 carbon atoms, and -OR represents a monovalent polyalkylene oxide group terminated by an alkoxy group. a is 0 or 1, b is 0 or 1, and n is an integer of 1-10.)

  提供了一种能产生 SHG 信号但抑制 TPF 信号产生的化合物。还提供了一种使用该化合物的细胞检查方法。一种用于产生光的二次谐波的化合物，该化合物是式 (1) 的偶氮苯衍生物或其盐。(R1和R2独立地代表具有6-12个碳原子的烷基，R3至R18独立地代表选自氢、卤素、烷基、烷氧基、芳基、氨基、羟基、硝基和氰基的取代基，R5和R6、R9和R10、R13和R14以及R17和R18可结合在一起并形成具有5-7个碳原子的环结构。X 代表-N+R19R20R21、磺酰基、羧基或-OR 基。这里，R19、R20 和 R21 独立地代表具有 1-5 个碳原子的直链或支链烷基，-OR 代表以烷氧基为末端的单价聚氧化亚烷基（a 是 0 或 1，b 是 0 或 1，n 是 1-10 的整数)。
• POLYESTER MASTERBATCH COMPOSITION
  申请人：Polymers Australia PTY Limited

  公开号：EP1641869A2

  公开（公告）日：2006-04-05