1-(2-fluorophenyl)-2-(4-methylphenylsulfonamido)ethyl nitrate | 1227184-75-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-fluorophenyl)-2-(4-methylphenylsulfonamido)ethyl nitrate
• 英文别名: [1-(2-Fluorophenyl)-2-[(4-methylphenyl)sulfonylamino]ethyl] nitrate
• CAS: 1227184-75-9
• 化学式: C₁₅H₁₅FN₂O₅S
• 分子量: 354.359
• InChiKey: SRTXXHZFCYIGCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-(2-fluorophenyl)-1-tosylaziridine 在 四硝基甲烷 、 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 336.0h， 以67%的产率得到1-(2-fluorophenyl)-2-(4-methylphenylsulfonamido)ethyl nitrate
  参考文献：
  名称：

  Ring opening of aziridines with tetranitromethane in the presence of triethylamine. Efficient synthesis of β-tosylamino nitrates

  摘要：

  A convenient method for the preparation of beta-tosylamino nitrates based on the ring-opening reaction of aziridines by tetranitromethane in the presence of triethylamine is described. A series of substituted beta-amino nitrates is obtained in high yields under mild conditions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.02.106

文献信息

• Ring opening of aziridines with tetranitromethane in the presence of triethylamine. Efficient synthesis of β-tosylamino nitrates
  作者：Yuliya A. Volkova、Elena B. Averina、Tamara S. Kuznetsova、Nikolai S. Zefirov

  DOI：10.1016/j.tetlet.2010.02.106

  日期：2010.4

  A convenient method for the preparation of beta-tosylamino nitrates based on the ring-opening reaction of aziridines by tetranitromethane in the presence of triethylamine is described. A series of substituted beta-amino nitrates is obtained in high yields under mild conditions. (C) 2010 Elsevier Ltd. All rights reserved.