2-苄基-3-甲基苯酚 | 30091-03-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-苄基-3-甲基苯酚
• 英文名称: 2-benzyl-3-methylphenol
• 英文别名: 3-Hydroxy-1-methyl-2-benzyl-benzol；2-Benzyl-3-methyl-phenol；O-benzylcresol
• CAS: 30091-03-3
• 化学式: C₁₄H₁₄O
• 分子量: 198.265
• InChiKey: AHKRMDMQOAEIKN-UHFFFAOYSA-N

物化性质

• 熔点：
  71-72 °C
• 沸点：
  157-159 °C
• 密度：
  1.0910 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-苄基-3-甲基苯酚 在 氯仿 、 溴 作用下， 生成 2-benzyl-4,6-dibromo-3-methyl-phenol
  参考文献：
  名称：

  ACTION OF AROMATIC ALCOHOLS ON AROMATIC COMPOUNDS IN THE PRESENCE OF ALUMINUM CHLORIDE. VIII. BENZYLATION OF META-CRESOL

  摘要：

  DOI：

  10.1021/ja01343a037
• 作为产物：
  描述：

  2-benzyl-3-methylcyclohex-2-en-1-one 在 palladium on activated charcoal 作用下， 生成 2-苄基-3-甲基苯酚
  参考文献：
  名称：

  Syntheses Related to Etiojervane. III. The Synthesis of 1,8-Dimethyl-7-methoxy-1,2,3,4,4a,9a-hexahydrofluoren-2-one¹

  摘要：

  DOI：

  10.1021/jo01059a105

文献信息

• [EN] ORGANIC COMPOUNDS<br/>[FR] COMPOSÉS ORGANIQUES
  申请人：GIVAUDAN SA

  公开号：WO2021174475A1

  公开（公告）日：2021-09-10

  Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucousa.

  揭示了按照式(I)定义的TRPM8调节剂，用于在皮肤和粘膜上产生降温效果。
• 4-chloro-2-phenylimidazole-5-acetic acid derivatives and use as
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US04582847A1

  公开（公告）日：1986-04-15

  Compounds of the formula ##STR1## wherein R is lower alkyl, and salts thereof. These compounds have excellent diuretic and antihypertensive actions in mammalian animals and are of use as therapeutic drugs for the treatment of edema and hypertension.

  式为##STR1##的化合物，其中R为低碳基，以及其盐。这些化合物在哺乳动物动物中具有出色的利尿和降压作用，并可用作治疗水肿和高血压的治疗药物。
• ANTITUMOR AGENT
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP0786252A1

  公开（公告）日：1997-07-30

  An anti-tumor agents against drug-resistant tumors, containing, as the active ingredient, a compound represented by the following formula, or its pharmaceutically-acceptable salt: wherein X is Cl or Br; R is NR1R2 (in which R1 and R2 independently represent hydrogen, or a linear or branched alkyl group with 1 to 4 carbon atoms), or in which R3 is -CH2- or N-CH3. The anti-tumor agent of the present invention exhibits an excellent anti-tumor activity against tumors resistant to clinical anticancer drugs, and is useful as an anti-tumor agent for drug-resistant tumors.

  一种针对抗药性肿瘤的抗肿瘤制剂，其活性成分含有下式所代表的化合物或其药学上可接受的盐： 其中 X 是 Cl 或 Br； R 是 NR1R2（其中 R1 和 R2 分别代表氢或 1 至 4 个碳原子的直链或支链烷基），或 其中 R3 是-CH2-或 N-CH3。 本发明的抗肿瘤剂对临床抗癌药物耐药的肿瘤具有很好的抗肿瘤活性，可用作耐药肿瘤的抗肿瘤剂。
• ORGANIC AMINE COLLECTION METHOD
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP3733644A1

  公开（公告）日：2020-11-04

  A method is provided for collecting a compound of formula (III) (in which R31 is a monovalent to trivalent organic group and n31 is an integer of 1 to 3) from a liquid phase component that is formed as a by-product in a method for producing a compound of general formula (I) (in which R11 is a monovalent to trivalent organic group and n 11 is an integer of 1 to 3), wherein the collection method contains steps (1) to (3) or steps (A) and (B), and step (4). Step (1): a step for reacting the liquid phase component with at least one active hydrogen-containing compound in a reactor. Step (2): a step for returning a condensed liquid obtained by cooling gas phase components in the reactor to the reactor. Step (3): a step for discharging gas phase components that are not condensed in the step (2) to the outside of the reactor. Step (A): a step for mixing the liquid phase component, water, and a compound of general formula (III). Step (B): a step for reacting the liquid phase component with water inside the reactor. Step (4): a step for discharging, as a liquid phase component inside the reactor, the reaction liquid containing the compound of general formula (III) to the outside of the reactor.         R11(̵NCO)n11     (I)         R31(̵NH2)n31     (III)

  本发明提供了一种从液相组分中收集式(III)化合物（其中 R31 为一价至三价有机基团，n31 为 1 至 3 的整数）的方法，该液相组分是在生产通式(I)化合物（其中 R11 为一价至三价有机基团，n 11 为 1 至 3 的整数）的方法中作为副产品形成的，其中收集方法包含步骤(1)至(3)或步骤(A)和(B)以及步骤(4)。步骤（1）：在反应器中使液相组分与至少一种活性含氢化合物反应的步骤。步骤(2)：将在反应器中冷却气相组分得到的冷凝液返回反应器的步骤。步骤（3）：将未在步骤（2）中冷凝的气相组分排放到反应器外部的步骤。步骤（A）：混合液相组分、水和通式（III）化合物的步骤。步骤（B）：在反应器内使液相成分与水反应的步骤。步骤(4)：在反应器内将含有通式(III)化合物的反应液作为液相组分排放到反应器外的步骤。 R11(̵NCO)n11 (I) R31(̵NH2)n31 (III)
• Crop fortification, nutrition and crop protection composition
  申请人：Sawant Arun Vitthal

  公开号：US10555536B2

  公开（公告）日：2020-02-11

  The invention relates to an algal granular composition. More particularly, the invention relates to an algal granular composition comprising at least one alga, and at least one agrochemically acceptable excipients selected from one or more of surfactants, binders or disintegrant having weight ratio of algae to at least one of surfactant, binder or disintegrant in the range of 99:1 to 1:99. The algae comprise 0.1% to 90% by weight of the total composition. The composition has a particle size in the range of 0.1 microns to 60 microns. Furthermore, the invention relates to a process of preparing the algal granular composition comprising at least one alga and at least one agrochemically acceptable excipient. The invention further relates to a method of treating the plants, seeds, crops, plant propagation material, locus, parts thereof or the soil with the algal granular composition.

  本发明涉及一种海藻颗粒组合物。更具体地说，本发明涉及一种藻类颗粒组合物，包括至少一种藻类和至少一种农用化学品可接受的赋形剂，赋形剂选自表面活性剂、粘合剂或崩解剂中的一种或多种，藻类与表面活性剂、粘合剂或崩解剂中至少一种的重量比在 99:1 至 1:99 之间。藻类占总成分重量的 0.1% 至 90%。组合物的粒径在 0.1 微米至 60 微米之间。此外，本发明还涉及一种制备海藻颗粒组合物的工艺，该组合物包括至少一种海藻和至少一种农用化学品可接受的赋形剂。本发明还涉及一种用藻类颗粒组合物处理植物、种子、作物、植物繁殖材料、所在地、其部分或土壤的方法。