N-(1-Pyridin-2-yl-ethylidene)-N'-(4-trifluoromethyl-phenyl)-hydrazine | 474787-61-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1-Pyridin-2-yl-ethylidene)-N'-(4-trifluoromethyl-phenyl)-hydrazine
• 英文别名: N-(1-pyridin-2-ylethylideneamino)-4-(trifluoromethyl)aniline
• CAS: 474787-61-6
• 化学式: C₁₄H₁₂F₃N₃
• 分子量: 279.265
• InChiKey: MLUFOSAYOWINNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-乙酰基吡啶 、 4-(三氟甲基)苯肼 以 乙醇 为溶剂， 反应 0.08h， 以96%的产率得到N-(1-Pyridin-2-yl-ethylidene)-N'-(4-trifluoromethyl-phenyl)-hydrazine
  参考文献：
  名称：

  Open Vessel and Cooling while Heating Microwave-Assisted Synthesis of Pyridinyl N-Aryl Hydrazones

  摘要：

  We reported the first example of open vessel and cooling while heating microwave-assisted synthesis of pyridinyl N-aryl hydrazones. Compounds were prepared in excellent isolated yields (88-98%) in only 5 min, by reacting 4- and 2,4-(di) substituted phenylhydrazines, bearing both electron-donating (4-CH3, 4-OCH3) and -withdrawing (4-Cl, 4-Br, 4CF(3), 4-NO2, 2,4-Cl-2) groups with 2-, 3-, and 4-acetylpyridine. The method was successfully extended to other carbonyl compounds.

  DOI：

  10.1021/co100015b

文献信息

• Open Vessel and Cooling while Heating Microwave-Assisted Synthesis of Pyridinyl <i>N</i>-Aryl Hydrazones
  作者：Giuseppe La Regina、Valerio Gatti、Francesco Piscitelli、Romano Silvestri

  DOI：10.1021/co100015b

  日期：2011.1.10

  We reported the first example of open vessel and cooling while heating microwave-assisted synthesis of pyridinyl N-aryl hydrazones. Compounds were prepared in excellent isolated yields (88-98%) in only 5 min, by reacting 4- and 2,4-(di) substituted phenylhydrazines, bearing both electron-donating (4-CH3, 4-OCH3) and -withdrawing (4-Cl, 4-Br, 4CF(3), 4-NO2, 2,4-Cl-2) groups with 2-, 3-, and 4-acetylpyridine. The method was successfully extended to other carbonyl compounds.