2-苄基巴豆醛 | 59578-89-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-苄基巴豆醛
• 英文名称: 2-benzylcrotonaldehyde
• 英文别名: 2-Benzylbut-2-enal
• CAS: 59578-89-1
• 化学式: C₁₁H₁₂O
• 分子量: 160.216
• InChiKey: YXSKKRTXSFHMFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-苄基巴豆醛 在 乙醇 、 钯 作用下， 生成 (2-甲基丁基)苯
  参考文献：
  名称：

  THE SYNTHESIS OF SIMPLE AND OF SUBSTITUTED 2-ALKYLCINNAMIC ALCOHOLS, INCLUDING A MONOMOLECULAR CUBEBIN

  摘要：

  DOI：

  10.1021/ja01355a069

文献信息

• Enantioselective 1,2-Addition of α-Aminoalkyl Radical to Aldehydes via Visible-Light Photoredox Initiated Chiral Oxazaborolidinium Ion Catalysis
  作者：Jae Yeon Kim、Yea Suel Lee、Yuna Choi、Do Hyun Ryu

  DOI：10.1021/acscatal.0c02443

  日期：2020.9.18

  Enantioselective 1,2-addition reaction of α-aminoalkyl radical to α,β-unsaturated or aromatic aldehydes to synthesize highly optically active β-amino alcohols has been developed. In the presence of chiral oxazaborolidinium ion catalyst and photosensitizer, the reaction provides desired β-amino allylic or benzylic alcohols with high yields (up to 99%) and high enantioselectivities (up to 98% ee).

  已经开发了α-氨基烷基与α，β-不饱和或芳族醛的对映选择性1，2-加成反应，以合成高度旋光活性的β-氨基醇。在手性恶唑硼烷鎓离子催化剂和光敏剂的存在下，反应以高产率（高达99％）和高对映选择性（高达98％ee）提供所需的β-氨基烯丙基或苄基醇。
• Organocatalytic Michael Addition of Indoles to α-Substituted Enals by Using a Diazepane Carboxylate Catalyst
  作者：Florent Larnaud、Adamo Sulpizi、Nicklas O. Häggman、Jonathan M. E. Hughes、Damien F. Dewez、James L. Gleason

  DOI：10.1002/ejoc.201700469

  日期：2017.5.10

  conjugate addition of indoles to α-substituted enals is achieved by using a diazepane carboxylate catalyst under mild conditions (20 mol-% catalyst, 20 mol-% TFA, acetonitrile, –20 °C). The low basicity and high nucleophilicity of this catalyst overcomes the limitations of allylic 1,3 strain in the intermediate iminium ions, which is normally observed with secondary-amine catalysts. Conjugate addition of

  通过在温和的条件下（20摩尔％的催化剂，20摩尔％的TFA，乙腈，–20°C）使用二氮杂环庚烷羧酸盐催化剂，将吲哚共轭添加到α-取代的烯醛中。该催化剂的低碱性和高亲核性克服了中间体亚胺离子中烯丙基1,3应变的局限性，这在仲胺催化剂中通常会观察到。证明了一系列取代的吲哚以及富含电子的芳族化合物与各种α-取代的烯类的共轭添加。
• METHOD FOR PRODUCING KAKEROMYCIN AND DERIVATIVES THEREOF
  申请人：OP BIO FACTORY CO., LTD.

  公开号：US20180037555A1

  公开（公告）日：2018-02-08

  Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.

  提供了一种生产kakeromycin及其衍生物的方法，该衍生物表现出抗真菌活性和细胞毒性，并被期望作为新的抗真菌剂或抗癌剂，通过化学合成。一种化合物的生产方法，该化合物由公式（1）表示：其中R是可选取代的烃基或可选取代的杂环基；n为0或1，或其盐，包括将由公式（2）表示的化合物进行氧化反应的步骤：其中R和n如上定义，或其盐。
• Process for preparing pyridine-2,3-dicarboxylic acid compounds
  申请人：SUGAI CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0274379A2

  公开（公告）日：1988-07-13

  A process for preparing pyridine-2,3-dicarboxylic acid compounds of the following formula:     wherein R¹ and R³ are, identical or different, each a hydrogen atom or a lower alkyl group, R² is a hydrogen atom, a lower alkyl group, or a phenyl-(lower)alkyl group which may have halogen atom or lower alkyl group on its phenyl ring, and R⁴ and R⁵ are, identical or different, each a lower alkoxy group. The compounds are useful as an intermediate for preparing agricultural chemicals and pharmaceuticals.

  一种制备下式吡啶-2,3-二羧酸化合物的工艺：其中 R¹ 和 R³ 相同或不同，各为氢原子或低级烷基；R² 为氢原子、低级烷基或苯基（低级）烷基，其苯基环上可能含有卤素原子或低级烷基；R⁴ 和 R⁵ 相同或不同，各为低级烷氧基。 该化合物可用作制备农药和药物的中间体。
• METAL MATERIAL WITH A BISMUTH FILM ATTACHED AND METHOD FOR PRODUCING SAME, SURFACE TREATMENT LIQUID USED IN SAID METHOD, AND CATIONIC ELECTRODEPOSITION COATED METAL MATERIAL AND METHOD FOR PRODUCING SAME
  申请人：NIHON PARKERIZING CO., LTD.

  公开号：EP2280096A1

  公开（公告）日：2011-02-02

  This invention provides a metal material with a bismuth coating being enables the subsequent coating to be accomplished at a high throwing power, and has excellent corrosion resistance, coating adhesion, and, being able to be produced with reduced damage to the environment, the metal material having a surface and a bismuth-containing layer deposited on at least a part of the surface of the metal material, wherein a percentage of bismuth atoms in number of atoms in the surface layer of the metal material with a bismuth coating is at least 10%.

  本发明提供了一种具有铋涂层的金属材料，该金属材料可在高投掷力下完成后续涂层，并具有优异的耐腐蚀性和涂层附着力，而且能够在生产过程中减少对环境的破坏，该金属材料具有一个表面和一个至少沉积在金属材料部分表面上的含铋层，其中铋原子在具有铋涂层的金属材料表面层的原子数中所占百分比至少为 10%。