2-苯二甲酰亚氨基-5-氨基酚 | 117346-08-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 中文名称: 2-苯二甲酰亚氨基-5-氨基酚
• 中文别名: 2-邻苯二甲酰亚氨基-5-氨基苯酚；2-苯二甲酰氨基-5-氨基苯酚
• 英文名称: N-(2-hydroxy-4-aminophenyl)phthalimide
• 英文别名: N-(4-amino-2-hydroxyphenyl)-phthalimide；2-(4-Amino-2-hydroxyphenyl)isoindoline-1,3-dione；2-(4-amino-2-hydroxyphenyl)isoindole-1,3-dione
• CAS: 117346-08-4
• 化学式: C₁₄H₁₀N₂O₃
• 分子量: 254.245
• InChiKey: WAHOJSICXGQOJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  4

SDS

Name:	N-(2-Hydroxy-4-aminophenyl)-phthalimide // Agfa Germany special Material Safety Data Sheet
Synonym:
CAS:	117346-08-4

Section 1 - Chemical Product MSDS Name:N-(2-Hydroxy-4-aminophenyl)-phthalimide // Agfa Germany special Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
117346-08-4	N-(2-Hydroxy-4-aminophenyl)-phthalimid		unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only in a chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 117346-08-4: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: grey
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 225 deg C
Autoignition Temperature: < 470 deg C (< 878.00 deg F)
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Negligible.
Specific Gravity/Density:
Molecular Formula: C14H10N2O3
Molecular Weight: 254.0816

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Not available.
Incompatibilities with Other Materials:
Not available.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 117346-08-4 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
N-(2-Hydroxy-4-aminophenyl)-phthalimide - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 22 Do not breathe dust.
S 24/25 Avoid contact with skin and eyes.
S 36 Wear suitable protective clothing.
WGK (Water Danger/Protection)
CAS# 117346-08-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 117346-08-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 117346-08-4 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-苯二甲酰亚氨基-5-氨基酚 、 甲基丙烯酰氯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 3.5h， 以52%的产率得到2-methyl-N-[3-hydroxy-4-(phthalimido)phenyl]acrylamide
  参考文献：
  名称：

  一种丙烯酰胺衍生物及其制备方法和用途

  摘要：

  本发明提供一种丙烯酰胺衍生物及其制备方法和用途，通式结构如下：其中，R为‑H，‑OH或‑COOH中的一个；R1为‑H，2‑OH或3‑OH中的一个。本发明的有益效果在于：本发明为苯二甲酰亚胺取代的丙烯酰胺衍生物，作为丙烯酸共聚物的一种共聚单体，解决丙烯酸共聚物对印刷化学品的耐蚀性；同时改善和提高平印版材的感度、耐磨性、显影适性。

  公开号：

  CN109824575A
• 作为产物：
  描述：

  N-(2-羟基-4-硝基苯基)邻苯二甲酰亚胺 在 tin(II) chloride dihdyrate 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以50.39%的产率得到2-苯二甲酰亚氨基-5-氨基酚
  参考文献：
  名称：

  一种丙烯酰胺衍生物及其制备方法和用途

  摘要：

  本发明提供一种丙烯酰胺衍生物及其制备方法和用途，通式结构如下：其中，R为‑H，‑OH或‑COOH中的一个；R1为‑H，2‑OH或3‑OH中的一个。本发明的有益效果在于：本发明为苯二甲酰亚胺取代的丙烯酰胺衍生物，作为丙烯酸共聚物的一种共聚单体，解决丙烯酸共聚物对印刷化学品的耐蚀性；同时改善和提高平印版材的感度、耐磨性、显影适性。

  公开号：

  CN109824575A

文献信息

• Process for the preparation of 2-amino-5-acylamino phenols and starting
  申请人：Agfa-Gevaert Aktiengesellschaft

  公开号：US04873338A1

  公开（公告）日：1989-10-10

  Compounds corresponding to Formula I ##STR1## wherein R.sup.1 denotes an acyl group and X denotes hydrogen, halogen, alkoxy, aroxy, SO.sub.3 H or a heterocyclic group attached through --O-- or --N< are prepared form a compound corresponding to Formula II ##STR2## wherein X has the meaning already indicated and Q denotes the group required for completing a dicarbonimide ring by reduction of the said compound to the amino compound and acylation into a compound corresponding to Formula III ##STR3## wherein X, Q and R.sup.1 have the meanings indicated followed by conversion of the compound corresponding to Formula III into a compound corresponding to Formula I by hydrazinolytic or hydrolytic decomposition of the dicarbonimide ring.

  将与Formula I对应的化合物制备成Formula II对应的化合物，其中R.sup.1代表酰基，X代表氢、卤素、烷氧基、芳基氧基、SO.sub.3 H或通过--O--或--N<连接的杂环基团。Formula II对应的化合物通过还原该化合物至氨基化合物并酰化形成Formula III对应的化合物，其中X、Q和R.sup.1具有相应的含义，然后将Formula III对应的化合物转化为Formula I对应的化合物，通过双碳亚胺环的叠氮解或水解分解。
• Fotografisches Farbkupplerhaltiges Aufzeichungsmaterial
  申请人：Agfa-Gevaert AG

  公开号：EP0653677A1

  公开（公告）日：1995-05-17

  Farbfotografisches Aufzeichnungsmaterial mit mindestens einer für den roten Spektralbereich sensibilisierten Silberhalogenidemulsionsschicht und einem Cyankuppler der nachstehenden Formel I. Die Cyankuppler der Formel I zeichnen sich durch eine steile Gradation, eine hohe maximale Farbdichte und eine hohe Farbausbeute aus. In Formel I bedeuten XH oder eine von Wasserstoff verschiedene, bei Farbkupplung freisetzbare Gruppe; Lein zweibindiges aliphatisches Bindeglied, insbesondere Alkylen oder Alkyliden mit 1 - 17 C-Atomen; R¹einen elektronenanziehenden Substituenten, z.B. -F, -CF₃, -CN, Carbamoyl, Alkoxycarbonyl, Alkylsulfonyl, Sulfamoyl, -SO₂F; R²H, Cl, Alkyl, Alkoxy, Alkylthio, Acylamino oder einen Rest wie R¹; R³Cycloalkyl; R⁴Halogen oder Alkoxy mit 1 bis 12 C-Atomen, wobei fall R⁴ Alkoxy bedeutet, beide ortho-Positionen (*) substituiert sind; m1 oder 2; n1, 2 oder 3.

  彩色感光记录材料，至少有一层对红色光谱范围感光的卤化银乳剂层和下式 I 的青色耦合剂。 在式 I 中 XH 或可在颜色偶合时释放的氢以外的基团； Lein 二价脂肪族连接剂，特别是具有 1 - 17 个 C 原子的亚烷基或亚烷基； R¹ 一个引电子取代基，如-F、-CF₃、-CN、氨基甲酰基、烷氧羰基、烷基磺酰基、氨基磺酰基、-SO₂F； R²H、Cl、烷基、烷氧基、烷硫基、酰氨基或诸如 R¹ 的基团； R³ 环烷基； R⁴卤素或含有 1 至 12 个 C 原子的烷氧基，其中如果 R⁴ 是烷氧基，则两个正交位置 (*) 均被取代； m1 或 2； n1、2 或 3。
• Oxidative dye couplers with novel auxochrome substituents and azomethine dyes and leuco forms thereof
  申请人：WELLA INTERNATIONAL OPERATIONS SWITZERLAND SÀRL

  公开号：US11339295B2

  公开（公告）日：2022-05-24

  The present invention concerns an auxochrome substituent for an oxidative dye coupler. The auxochrome substituent enables ready developer reaction with the coupler to form azomethine and leuco dyes. Manipulation of the auxochrome substituent enables a bathochromic or hypsochromic shift of the light absorbance by the azomethine dye formed with the auxochrome substituted coupler.

  本发明涉及一种氧化染料偶联剂的助色取代基。助色取代基能使显影剂与耦合剂发生反应，生成偶氮甲胺染料和白基染料。操纵助色取代基可以使与助色取代的偶联剂形成的偶氮染料的光吸收率发生浴变色或次变色偏移。
• US4873338A
  申请人：——

  公开号：US4873338A

  公开（公告）日：1989-10-10
• 一种丙烯酰胺衍生物及其制备方法和用途
  申请人：辽宁靖帆新材料有限公司

  公开号：CN109824575A

  公开（公告）日：2019-05-31

  本发明提供一种丙烯酰胺衍生物及其制备方法和用途，通式结构如下：其中，R为‑H，‑OH或‑COOH中的一个；R1为‑H，2‑OH或3‑OH中的一个。本发明的有益效果在于：本发明为苯二甲酰亚胺取代的丙烯酰胺衍生物，作为丙烯酸共聚物的一种共聚单体，解决丙烯酸共聚物对印刷化学品的耐蚀性；同时改善和提高平印版材的感度、耐磨性、显影适性。