2-(2-Hydroxyphenyl)-3-(1,2,4-triazol-4-yl)-1,3-thiazolidin-4-one | 1141752-85-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(2-Hydroxyphenyl)-3-(1,2,4-triazol-4-yl)-1,3-thiazolidin-4-one
• CAS: 1141752-85-3
• 化学式: C₁₁H₁₀N₄O₂S
• 分子量: 262.292
• InChiKey: WHEBHDCVNMOLCV-UHFFFAOYSA-N

物化性质

• 熔点：
  158 °C
• 沸点：
  453.5±55.0 °C(predicted)
• 密度：
  1.59±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  96.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (6E)-6-[(1,2,4-三唑-4-基氨基)亚甲基]环己-2,4-二烯-1-酮 、 巯基乙酸 在 zinc(II) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以58%的产率得到2-(2-Hydroxyphenyl)-3-(1,2,4-triazol-4-yl)-1,3-thiazolidin-4-one
  参考文献：
  名称：

  Synthesis and Biological Activity of 3-[4H-(1,2,4)-triazolyl]-2-aryl-1,3-thiazolidin-4-ones

  摘要：

  4-Amino-1,2,4-triazole (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-(arylidene-amino)-4H-[1,2,4]-triazole (2 a-h) in good yields. Cyclocondensation of compounds (2 a-h) with thioglycolic acid yields 3-[4H-(1,2,4)-triazolyl]-2-aryl-1,3-thiazolidin-4-ones (3 a-h). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

  DOI：

  10.1080/10426500801963772

文献信息

• Synthesis and Biological Activity of 3-[4<i>H</i>-(1,2,4)-triazolyl]-2-aryl-1,3-thiazolidin-4-ones
  作者：H. S. Patel、K. B. Patel

  DOI：10.1080/10426500801963772

  日期：2008.9.15

  4-Amino-1,2,4-triazole (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-(arylidene-amino)-4H-[1,2,4]-triazole (2 a-h) in good yields. Cyclocondensation of compounds (2 a-h) with thioglycolic acid yields 3-[4H-(1,2,4)-triazolyl]-2-aryl-1,3-thiazolidin-4-ones (3 a-h). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.