2-苯基-3-丁烯酰胺 | 103205-11-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-苯基-3-丁烯酰胺
• 英文名称: Vinyl-phenyl-acetamid
• 英文别名: 2-Phenylbut-3-enamide
• CAS: 103205-11-4
• 化学式: C₁₀H₁₁NO
• 分子量: 161.203
• InChiKey: HPOMWJQYAHJMNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-苯基-3-丁烯酰胺 在 氢氧化钾 、 sodium hypobromide 作用下， 以 乙醇 、 水 为溶剂， 生成 Dicinnamyl-disulfid
  参考文献：
  名称：

  Iliceto,A.; Gaggia,G., Gazzetta Chimica Italiana, 1960, vol. 90, p. 262 - 268

  摘要：

  DOI：
• 作为产物：
  描述：

  2-phenyl-3-butenoic acid 生成 2-苯基-3-丁烯酰胺
  参考文献：
  名称：

  Iliceto,A.; Gaggia,G., Gazzetta Chimica Italiana, 1960, vol. 90, p. 262 - 268

  摘要：

  DOI：

文献信息

• [EN] FORMAMIDE MONOMERS AND POLYMERS SYNTHESIZED THEREFROM<br/>[FR] MONOMÈRES DE FORMAMIDE ET POLYMÈRES SYNTHÉTISÉS À PARTIR DE CEUX-CI
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2020185872A1

  公开（公告）日：2020-09-17

  Formamide group-containing monomers and polymers made by polymerizing the monomers are provided. Also provided are methods of polymerizing the monomers and methods of synthesizing functionalized polymers by pre- and/or post-polymerization functionalization. The monomers are non-toxic and can generate highly reactive isocyanate and isonitrile precursors in a one-pot synthesisthat enables the incorporation of complex functionalities into the side-chain of the polymers that are synthesized from the monomers.

  提供了通过聚合含有甲酰胺基团的单体制备的单体和聚合物。还提供了聚合这些单体的方法以及通过聚合前和/或聚合后功能化合成功能化聚合物的方法。这些单体是无毒的，可以在一个锅合成过程中产生高度活性的异氰酸酯和异腈前体，从而使从这些单体合成的聚合物的侧链中能够加入复杂的功能基团。
• ANTI-CANCER COMPOSITIONS AND METHODS
  申请人：Robertson Gavin P.

  公开号：US20080306148A1

  公开（公告）日：2008-12-11

  Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.

  本发明涉及一种抗癌组合物和方法，其中包括一种或多种异硫氰酸酯和/或异硒氰酸酯。根据本发明的实施例提供了治疗主体的方法，包括向具有Akt失调特征的主体施用包括异硫氰酸酯和/或异硒氰酸酯的治疗有效量的组合物。向主体施用包括异硫氰酸酯和/或异硒氰酸酯的治疗有效量的组合物，可以明显增加细胞凋亡和/或减少具有Akt失调特征的癌细胞的增殖，特别是癌细胞。
• Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes
  申请人：McDaniel C. Steven

  公开号：US20100210745A1

  公开（公告）日：2010-08-19

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peotide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文公开了一些聚合材料，如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；一种表面处理，如纺织品涂层或蜡；一种填料，用于这样的聚合材料或表面处理，其中包括一种酶，如酯酶（例如，脂肪水解酶，硫酸酯水解酶，有机磷化合物降解酶），降解细胞壁和/或细胞膜成分的酶（例如，溶菌酶，裂解转糖基酶），生物杀菌或生物静态肽，以及/或肽酶。本文还公开了通过将酶纳入可通过脂肪水解酶、水解酶和/或脲酶的活性交联材料中来改变材料性能，如使用寿命、柔韧性或刚度的方法。
• Polymeric Coatings Incorporating Bioactive Enzymes for Catalytic Function
  申请人：McDaniel C. Steven

  公开号：US20120097194A1

  公开（公告）日：2012-04-26

  Disclosed herein are materials including a polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a coating, a textile finish or a wax; a filler for such a polymeric material or a surface treatment, which includes an enzyme such as an esterase (e.g., a lipolytic enzyme, an organophosphorus compound degradation enzyme), wherein the enzyme decontaminates a chemical from the surface of the material. Also disclosed herein are methods of cleaning a surface of a material that comprises an enzyme.

  本文公开了一种材料，包括聚合物材料，例如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；表面处理，例如涂层、纺织品处理或蜡；用于上述聚合物材料或表面处理的填料，其中包括酶，例如酯酶（例如脂肪水解酶、有机磷化合物降解酶），其中酶可从材料表面去除化学物质。本文还公开了一种清洁含有酶的材料表面的方法。
• Polymeric Coatings Incorporating Bioactive Enzymes for Cleaning a Surface
  申请人：Wales Melinda

  公开号：US20110240064A1

  公开（公告）日：2011-10-06

  Disclosed herein are a materials such as a coating, such as an architectural coating or a CARC coating, comprising a lipolytic enzyme or organophosphorous compound degrading enzyme. Also disclosed herein are methods of decontaminating a surface comprising such a material from a chemical substrate of an enzyme such as a lipid or an organophosphorus compound.

  本文公开了一种材料，例如涂层，如建筑涂层或CARC涂层，包括脂肪水解酶或有机磷化合物降解酶。本文还公开了一种从酶的化学底物，例如脂质或有机磷化合物，中去除此类材料表面的污染物的方法。