2-苯基-3-呋喃胺 | 1211915-92-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-苯基-3-呋喃胺
• 英文名称: 2-phenyl-3-furanamine
• 英文别名: 2-Phenylfuran-3-amine
• CAS: 1211915-92-2
• 化学式: C₁₀H₉NO
• 分子量: 159.188
• InChiKey: UONIHABBKBOOGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  39.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-methyl-4-(trifluoromethyl)-1H-pyrrole-3-carbonyl chloride 、 2-苯基-3-呋喃胺 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 以38%的产率得到1-methyl-N-(2-phenyl-3-furyl)-4-(trifluoromethyl)-1H-pyrrole-3-carboxamide
  参考文献：
  名称：

  Synthesis of potential fungicides based on N-(3-furanyl)pyrrolecarboxamides and N-(3-furanyl)pyrazolecarboxamides

  摘要：

  An efficient synthesis of novel N-(3-furanyl)pyrrolecarboxamides and N-(3-furanyl)pyrazolecarboxamides is presented starting from furan-3-carboxylic acid. Two complementary strategies to 2-aryl-3-furanamines with directed ortho lithiation, functionalization of the 2-position, and subsequent cross-coupling reaction as key steps were developed. Acylation of these intermediates with appropriate acid chlorides led finally to the target compounds.

  DOI：

  10.1007/s00706-009-0187-6
• 作为产物：
  描述：

  N-(2-phenyl-3-furyl)carbamic acid tert-butyl ester 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以61%的产率得到2-苯基-3-呋喃胺
  参考文献：
  名称：

  Synthesis of potential fungicides based on N-(3-furanyl)pyrrolecarboxamides and N-(3-furanyl)pyrazolecarboxamides

  摘要：

  An efficient synthesis of novel N-(3-furanyl)pyrrolecarboxamides and N-(3-furanyl)pyrazolecarboxamides is presented starting from furan-3-carboxylic acid. Two complementary strategies to 2-aryl-3-furanamines with directed ortho lithiation, functionalization of the 2-position, and subsequent cross-coupling reaction as key steps were developed. Acylation of these intermediates with appropriate acid chlorides led finally to the target compounds.

  DOI：

  10.1007/s00706-009-0187-6

文献信息

• Synthesis and antimicrobial activity of novel dicationic "reversed amidines"
  申请人：——

  公开号：US20040235927A1

  公开（公告）日：2004-11-25

  The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino]aminophenyl}furans and thiophenes of the general formula 1 in which R 1 , R 2 , R 3 and R 4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R 5 is H, alkyl or aryl; R 6 is H, alkyl, aryl, or NR 7 R 8 , in which R 7 and R 8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR 9 , in which R 9 is H or alkyl, and to the use of such compounds.

  本发明涉及新型的2,5-双{[烷基（或芳基）亚胺]氨基苯基}呋喃和噻吩，其通式为1，其中R1、R2、R3和R4各自独立地选自H、烷基、烷氧基、卤素和烷基卤素基团；R5为H、烷基或芳基；R6为H、烷基、芳基或NR7R8，其中R7和R8各自独立地选自H、烷基和芳基；X为O、S或NR9，其中R9为H或烷基，并且涉及这种化合物的用途。
• Synthesis and antimicrobial activity of novel dicationic"reversed amidines"
  申请人：——

  公开号：US20030083362A1

  公开（公告）日：2003-05-01

  The present invention relates to novel 2,5-bis {[alkyl (or aryl) imino] aminophenyl} furans and thiophenes of the general formula 1 in which R 1 , R 2 , R 3 and R 4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R 5 is H, alkyl or aryl; R 6 is H, alkyl, aryl, or NR 7 R 8 , in which R 7 and R 8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR 9 , in which R 9 is H or alkyl, and to the use of such compounds.

  本发明涉及一种新型的2,5-双{[烷基（或芳基）亚胺]氨基苯基呋喃和噻吩，其通式为1，其中R1、R2、R3和R4分别独立地选自H、烷基、烷氧基、卤素和烷基卤素基团；R5为H、烷基或芳基；R6为H、烷基、芳基或NR7R8，其中R7和R8分别独立地选自H、烷基和芳基；X为O、S或NR9，其中R9为H或烷基，并且涉及这些化合物的使用。
• SYNTHESIS AND ANTIMICROBIAL ACTIVITYOF NOVEL DICATIONIC "REVERSED AMIDINES"
  申请人：UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

  公开号：EP1337510A2

  公开（公告）日：2003-08-27
• US7241795B2
  申请人：——

  公开号：US7241795B2

  公开（公告）日：2007-07-10
• [EN] SYNTHESIS AND ANTIMICROBIAL ACTIVITYOF NOVEL DICATIONIC "REVERSED AMIDINES"<br/>[FR] SYNTHESE ET ACTIVITE ANTIMICROBIENNE DE NOUVELLES = AMIDINES INVERSEES >/= DICATIONIQUES
  申请人：UNIV NORTH CAROLINA

  公开号：WO2002057224A2

  公开（公告）日：2002-07-25

  The present invention relates to novel 2,5-bis[alkyl (or aryl) imino] aminophenyl} furans and thiophenes of the general formula (I) in which R1, R2, R3 and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R5 is H, alkyl or aryl; R6 is H, alkyl, aryl, or NR7R8, in which R7 and R8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR9, in which R9 is H or alkyl, and to the use of such compounds.