zinc 2,3,9,10,16,17,23,24-tetra(isopropylidenedioxy)phthalocyanine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: zinc 2,3,9,10,16,17,23,24-tetra(isopropylidenedioxy)phthalocyanine
• 英文别名: zinc;8,8,20,20,32,32,44,44-octamethyl-7,9,19,21,31,33,43,45-octaoxa-2,14,26,38,49,50-hexaza-51,52-diazanidatridecacyclo[37.9.1.13,13.115,25.127,37.04,12.06,10.016,24.018,22.028,36.030,34.040,48.042,46]dopentaconta-1,3,5,10,12,14,16,18(22),23,25,27(50),28,30(34),35,37,39(49),40,42(46),47-nonadecaene
• 化学式: C₄₄H₃₂N₈O₈*Zn
• 分子量: 866.177
• InChiKey: BQWXQKYONASDGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.15
• 重原子数：
  61
• 可旋转键数：
  0
• 环数：
  13.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  150
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  zinc 2,3,9,10,16,17,23,24-tetra(isopropylidenedioxy)phthalocyanine 在 硫酸 作用下， 以 硫酸 为溶剂， 以94%的产率得到(2,3,9,10,16,17,23,24-octahydroxyphthalocyaninato)zinc(II)
  参考文献：
  名称：

  摘要：

  A series of new metal monophthalocyanine complexes were synthesized from 4,5-iso-propylidenedioxyphthalonitrile and their spectroscopic and electrochemical properties were studied. The removal of the protective isopropylidene groups from these compounds afforded symmetrically substituted octahydroxyphthalocyanines.

  DOI：

  10.1023/a:1025693009575
• 作为产物：
  描述：

  2,2-二甲基-1,3-苯并二恶茂烷 在 N-溴代丁二酰亚胺(NBS) 、 lithium 作用下， 以 戊醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 46.0h， 生成 zinc 2,3,9,10,16,17,23,24-tetra(isopropylidenedioxy)phthalocyanine
  参考文献：
  名称：

  Cyclodextrin Dimers as Cleavable Carriers of Photodynamic Sensitizers

  摘要：

  Several phthalocyanines carrying hydrophobic components have been synthesized and shown to bind to a group of cyclodextrin dimers with a carbon-carbon double bond in the linker. The complexes are soluble in water. On irradiation in the presence of oxygen, the singlet oxygen produced cleaves the olefinic linkers in the complexes, resulting in precipitation of the sensitizers. This process concentrates the sensitizers in the light beam, a process that has useful potential in photodynamic therapy.

  DOI：

  10.1021/ja011709o

文献信息

• [EN] COVALENT ORGANIC FRAMEWORKS AND METHODS OF MAKING SAME<br/>[FR] STRUCTURES ORGANIQUES COVALENTES ET PROCÉDÉS POUR LEUR FABRICATION
  申请人：UNIV CORNELL

  公开号：WO2011127301A3

  公开（公告）日：2012-04-19
• Cyclodextrin Dimers as Cleavable Carriers of Photodynamic Sensitizers
  作者：Simon D. P. Baugh、Zhiwei Yang、David K. Leung、David M. Wilson、Ronald Breslow

  DOI：10.1021/ja011709o

  日期：2001.12.19

  Several phthalocyanines carrying hydrophobic components have been synthesized and shown to bind to a group of cyclodextrin dimers with a carbon-carbon double bond in the linker. The complexes are soluble in water. On irradiation in the presence of oxygen, the singlet oxygen produced cleaves the olefinic linkers in the complexes, resulting in precipitation of the sensitizers. This process concentrates the sensitizers in the light beam, a process that has useful potential in photodynamic therapy.
• ——
  作者：A. V. Ivanov、P. A. Svinareva、I. V. Zhukov、L. G. Tomilova、N. S. Zefirov

  DOI：10.1023/a:1025693009575

  日期：——

  A series of new metal monophthalocyanine complexes were synthesized from 4,5-iso-propylidenedioxyphthalonitrile and their spectroscopic and electrochemical properties were studied. The removal of the protective isopropylidene groups from these compounds afforded symmetrically substituted octahydroxyphthalocyanines.