2-苯基-5-(三氯甲基)-1,3,4-恶二唑 | 1456-20-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-苯基-5-(三氯甲基)-1,3,4-恶二唑
• 英文名称: 5-phenyl-2-trichloromethyl-1,3,4-oxadiazole
• 英文别名: 2-phenyl-5-trichloromethyl-1,3,4-oxadiazole；2-(trichloromethyl)-5-(phenyl)-1,3,4-oxadiazole；2-Trichlormethyl-5-phenyl-1,3,4-oxadiazol；2-Phenyl-5-(trichloromethyl)-1,3,4-oxadiazole
• CAS: 1456-20-8
• 化学式: C₉H₅Cl₃N₂O
• 分子量: 263.51
• InChiKey: ZJUAJDHQUFXWLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  38.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯甲酰肼 、 三氯乙酸 在 aluminum oxide 、 三氯氧磷 作用下， 以88%的产率得到2-苯基-5-(三氯甲基)-1,3,4-恶二唑
  参考文献：
  名称：

  2,5-Disubstituted-1,3,4-oxadiazoles: thymidine phosphorylase inhibitors

  摘要：

  A series of 2,5-disubstituted-1,3,4-oxadiazoles (1-16) were synthesized via microwave irradiation and screened against thymidine phosphorylase enzyme. Four members of the series have demonstrated thymidine phosphorylase inhibitory activities with IC50 values between 37 and 320 mu M. Pyridinyl-containing 1,3,4-oxadiazoles exhibited an enhanced inhibitory potential, while phenyl analogs did not show substantial inhibitory potential. Compound 9, a dipyridinyl residue having an IC50 value of 37 +/- A 0.76 mu M was found to be the most potent in the series superior to standard inhibitor 7-deazaxanthine (IC50 = 39.28 +/- A 0.76 mu M).

  DOI：

  10.1007/s00044-013-0588-2

文献信息

• LASER-DECOMPOSABLE RESIN COMPOSITION AND PATTERN-FORMING MATERIAL USING THE SAME
  申请人：SUGASAKI Atsushi

  公开号：US20080038663A1

  公开（公告）日：2008-02-14

  A laser-decomposable resin composition contains: a compound including at least one structure selected from a carboxyl group and a carboxylic acid anhydride structure and at least one hetero atom selected from N, S and O atoms other than the structure; and a binder polymer.

  一种可激光分解的树脂组合物，包括：一种化合物，其中包括至少一种结构，所述结构从羧基和羧酸酐结构中选择至少一种，并且还包括至少一种异原子，所述异原子选自N、S和O原子以外的结构；以及一种粘合剂聚合物。
• POLYMERIZABLE COMPOSITION AND LITHOGRAPHIC PRINTING PLATE PRECURSOR
  申请人：Sugasaki Atsushi

  公开号：US20090053653A1

  公开（公告）日：2009-02-26

  A polymerizable composition comprising: a polyurethane resin synthesized by using a compound represented by the following formula (I) as one of starting materials; a photopolymerization or thermal polymerization initiator; and an addition-polymerizable compound having an ethylenically unsaturated bond: wherein X represents a tri- or higher valent atom; R 1 and R 2 each independently represent a single bond or an alkylene group optionally having a substituent, provided that R 1 and R 2 do not represent a single bond at a same time; A represents a straight chain linking group; and n is an integer of from 1 to 5.

  一种可聚合的组合物，包括：由使用以下式(I)所表示的化合物之一作为起始材料合成的聚氨酯树脂；光聚合或热聚合引发剂；以及具有乙烯基不饱和键的加成聚合化合物：其中，X代表三价或更高价原子；R1和R2各自独立地表示单键或具有取代基的烷基基团，但R1和R2不能同时表示单键；A表示直链连接基团；n为1到5的整数。
• OPTICAL FILM, POLARIZING PLATE AND IMAGE DISPLAY DEVICE
  申请人：WAKIZAKA Daiki

  公开号：US20090081447A1

  公开（公告）日：2009-03-26

  An optical film, includes: a transparent support; and at least one low refractive index layer, wherein the at least one low refractive index layer is a layer formed from a coating composition containing: (A) an inorganic fine particle; (B) a fluorine-containing copolymer; and (C) a polyfunctional fluorine-containing acrylate, and the polyfunctional fluorine-containing acrylate (C) is represented by the following structural formula: wherein Rf represents a (p+q)-valent perfluoro saturated hydrocarbon group having a carbon number of 1 to 20, which may have an ether bond; p represents an integer of 2 to 10; q represents an integer of 0 to 8, provided that (p+q) represents an integer of 2 to 10; r represents an integer of 0 to 100; and R represents a hydrogen atom, a methyl group, a fluorine atom or a trifluoromethyl group.

  一种光学薄膜，包括：透明支撑层；以及至少一层低折射率层，其中所述至少一层低折射率层为由含有以下成分的涂层组合物形成的层：（A）无机细颗粒；（B）含氟共聚物；以及（C）多官能团含氟丙烯酸酯，其中多官能团含氟丙烯酸酯（C）由以下结构式表示：其中，Rf代表碳数为1到20的(p+q)-价全氟饱和烃基，可以具有醚键；p表示2到10的整数；q表示0到8的整数，条件是(p+q)表示2到10的整数；r表示0到100的整数；R表示氢原子、甲基、氟原子或三氟甲基基团。
• Polymer latex of high acrylonitrile content, film, pattern forming material and lithographic printing plate precursor using the same, and method for production of polymer latex
  申请人：FUJIFILM Corporation

  公开号：EP1905787A2

  公开（公告）日：2008-04-02

  A method for producing a polymer latex includes: mixing a polymerizable monomer in which acrylonitrile accounts for 70% by weight or more of a total of the polymerizable monomer, water and a polymerization initiator to conduct emulsion polymerization; and distilling off a monomer unpolymerized in the emulsion polymerization.

  生产聚合物胶乳的方法包括：混合可聚合单体（其中丙烯腈占可聚合单体总重量的 70% 或以上）、水和聚合引发剂，以进行乳液聚合；以及蒸馏掉乳液聚合中未聚合的单体。
• Laser-decomposable resin composition, and pattern-forming material and laser-engravable flexographic printing plate precursor using the same
  申请人：FUJIFILM Corporation

  公开号：EP1939244A2

  公开（公告）日：2008-07-02

  A laser-decomposable resin composition includes (A) at least one selected from the group consisting of a carbon nanotube and a fullerene; and (B) a binder polymer.

  一种可激光分解的树脂组合物包括 (A) 至少一种碳纳米管和富勒烯；以及 (B) 一种粘合剂聚合物。