2-苯基乙基-D9-胺 | 342611-05-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-苯基乙基-D9-胺
• 英文名称: [1,1,2,2,2',3',4',5',6'-2H9]-2-phenylethylamine
• 英文别名: 2-Phenylethyl-D9-amine；1,1,2,2-tetradeuterio-2-(2,3,4,5,6-pentadeuteriophenyl)ethanamine
• CAS: 342611-05-6
• 化学式: C₈H₁₁N
• 分子量: 130.111
• InChiKey: BHHGXPLMPWCGHP-NVLGFDPUSA-N

物化性质

• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3,4,5,6-五氟苯磺酰氯 、 2-苯基乙基-D9-胺 生成 2,3,4,5,6-pentadeuterio-N-[1,1,2,2-tetradeuterio-2-(2,3,4,5,6-pentafluorophenyl)ethyl]benzenesulfonamide
  参考文献：
  名称：

  NAGATA, KATSUMI;HAYASHI, TOKISHI;NARUSE, HIROSHI;IIDA, VOSHIO, ANAL. LETT., 22,(1989) N0, C. 2281-2290

  摘要：

  DOI：
• 作为产物：
  描述：

  (2H5)苯基(2H2)乙腈 在 三氯化铝 、 lithium aluminium deuteride 作用下， 以 乙醚 为溶剂， 反应 1.0h， 生成 2-苯基乙基-D9-胺
  参考文献：
  名称：

  Emission of 2-phenylethanol from its β-d-glucopyranoside and the biogenesis of these compounds from [2H8] l-phenylalanine in rose flowers

  摘要：

  The hydrolysis of 2-phenylethyl beta-D-glucopyranoside (3) was found to be partially inhibited by feeding with 2-phenyl-N-glucosyl-acetamidiumbromide (8), a beta-glucosidase inhibitor, resulting in a decrease in the diurnal emission of 2-phenylethanol (2) from Rosa damascena Mill. flowers. Detection of [1,1,2,2',3,4',5',6'-H-2(8)]-2 and [1,2,2',3,4,5',6'-H-2(7)]-2 from R. 'Hoh-Jun' flowers fed with [1,1,2,2',3',4',5',6'-H-2(8)]-3 suggested that beta-glucosidase, alcohol dehydrogenase, and reductase might be involved in scent emission. Comprehensive GC-SIM analyses revealed that [1,2,2,2',3',4',5',6'-H-2(8)]-2 and [1,2,2,2',3',4',5',6'-H-2(8)]-3 must be biosynthesized from [1,2,2,2',3',4',5'6'-H-2(8)] L-phenylalanine ([H-2(8)]-1) with a retention of the deuterium atom at alpha-position of [H-2(8)]-1. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2003.10.130

文献信息

• NAGATA, KATSUMI;HAYASHI, TOKISHI;NARUSE, HIROSHI;IIDA, VOSHIO, ANAL. LETT., 22,(1989) N0, C. 2281-2290
  作者：NAGATA, KATSUMI、HAYASHI, TOKISHI、NARUSE, HIROSHI、IIDA, VOSHIO

  DOI：——

  日期：——
• DEUTERATED SERINE-THREONINE PROTEIN KINASE MODULATORS
  申请人：HADDACH Mustapha

  公开号：US20120129849A1

  公开（公告）日：2012-05-24

  The present invention provides deuterated compounds having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. The deuterated compounds of the invention can modulate casein kinase (CK) activity and/or poly(ADP-ribose)polymerase (PARP) activity. The invention also relates in part to methods for using such deuterated compounds as therapeutic agents.
• Emission of 2-phenylethanol from its β-d-glucopyranoside and the biogenesis of these compounds from [2H8] l-phenylalanine in rose flowers
  作者：Shunsuke Hayashi、Kensuke Yagi、Takashi Ishikawa、Miwa Kawasaki、Tatsuo Asai、Joanne Picone、Colin Turnbull、Jun Hiratake、Kanzo Sakata、Masayasu Takada、Koji Ogawa、Naoharu Watanabe

  DOI：10.1016/j.tet.2003.10.130

  日期：2004.8

  The hydrolysis of 2-phenylethyl beta-D-glucopyranoside (3) was found to be partially inhibited by feeding with 2-phenyl-N-glucosyl-acetamidiumbromide (8), a beta-glucosidase inhibitor, resulting in a decrease in the diurnal emission of 2-phenylethanol (2) from Rosa damascena Mill. flowers. Detection of [1,1,2,2',3,4',5',6'-H-2(8)]-2 and [1,2,2',3,4,5',6'-H-2(7)]-2 from R. 'Hoh-Jun' flowers fed with [1,1,2,2',3',4',5',6'-H-2(8)]-3 suggested that beta-glucosidase, alcohol dehydrogenase, and reductase might be involved in scent emission. Comprehensive GC-SIM analyses revealed that [1,2,2,2',3',4',5',6'-H-2(8)]-2 and [1,2,2,2',3',4',5',6'-H-2(8)]-3 must be biosynthesized from [1,2,2,2',3',4',5'6'-H-2(8)] L-phenylalanine ([H-2(8)]-1) with a retention of the deuterium atom at alpha-position of [H-2(8)]-1. (C) 2004 Elsevier Ltd. All rights reserved.