candicine iodide | 1976-98-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: candicine iodide
• 英文别名: hordenine methiodide；(4-hydroxyphenethyl)trimethylammonium iodide；4-Hydroxy-β-phenaethyl-trimethylammonium；(4-Hydroxy-phenaethyl)-trimethyl-ammonium; Jodid；4-[2-(Trimethylazaniumyl)ethyl]phenolate;hydroiodide；4-[2-(trimethylazaniumyl)ethyl]phenolate;hydroiodide
• CAS: 1976-98-3
• 化学式: C₁₁H₁₈NO*I
• 分子量: 307.175
• InChiKey: KSKJBRYLJGRXCN-UHFFFAOYSA-N

物化性质

• 熔点：
  229-230 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -2.26
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  candicine iodide 生成 大麦芽碱
  参考文献：
  名称：

  DE233069

  摘要：

  公开号：
• 作为产物：
  描述：

  3-(4-甲氧基苯基)-丙酰胺 在 盐酸 、 甲醇 、 次溴酸钾 、 氢碘酸 、 sodium acetate 、 sodium 、 xylene 作用下， 生成 candicine iodide
  参考文献：
  名称：

  Interactive Effect of Support From Family and Friends in Visually Impaired Elders

  摘要：

  The interactive relationship of high and low friend and family support for adaptation to chronic vision impairment was examined in 241 men and women. Two 2 (High/Low Family Support) X 2 (High/Low Friend Support) X 2 (Gender) multivariate analyses of covariance tested for psychological well-being, one with qualitative support measures, the other with quantitative support measures. Two analyses of covariance models tested for adaptation to vision loss. A significant multivariate 3-way interaction effect for qualitative support was found. Women with high support from both friends and family had better psychological well-being, whereas men with high support from both friends and family or just from family had better psychological well-being. Two univariate main effects showed that participants with high qualitative friend support and high quantitative family support had better adaptation to vision loss. Findings demonstrate the complexity of measuring and understanding relationships among social support, well-being, and domain-specific adaptation to chronic impairment.

  DOI：

  10.1093/geronb/56.6.p374

文献信息

• Synthetic analogs of stryphnusin isolated from the marine sponge Stryphnus fortis inhibit acetylcholinesterase with no effect on muscle function or neuromuscular transmission
  作者：Lindon W. K. Moodie、Monika C. Žužek、Robert Frangež、Jeanette H. Andersen、Espen Hansen、Elisabeth K. Olsen、Marija Cergolj、Kristina Sepčić、Kine Ø. Hansen、Johan Svenson

  DOI：10.1039/c6ob02120d

  日期：——

  The marine secondary metabolite stryphnusin (1) was isolated from the boreal sponge Stryphnus fortis, collected off the Norwegian coast. Given its resemblance to other natural acetylcholinesterase antagonists, it was evaluated against electric eel acetylcholinesterase and displayed inhibitory activity. A library of twelve synthetic phenethylamine analogs, 2a–7a and 2b–7b, containing tertiary and quaternary

  从挪威海岸附近收集的北方海绵体Stryphnus fortis中分离出海洋次生代谢产物石豚链菌素（1）。鉴于其与其他天然乙酰胆碱酯酶拮抗剂的相似性，对其进行了抗鳗鳗乙酰胆碱酯酶的评估，并显示出抑制活性。合成了分别包含叔胺和季胺的十二种合成苯乙胺类似物2a-7a和2b-7b的文库，以研究各个结构对活性的贡献。化合物7b是乙酰胆碱酯酶和丁酰胆碱酯酶的最强竞争抑制剂，IC 50值分别为57和20μM。这种抑制活性比阳性对照毒扁豆碱高一个数量级，可与其他几种海洋乙酰胆碱酯酶抑制剂相媲美。研究了化合物7b对肌肉功能和神经肌肉传递的生理作用，并揭示了在所研究浓度下的选择性作用方式。该数据非常重要，因为治疗性乙酰胆碱酯酶抑制剂对神经肌肉传递的干扰可能会成问题，并导致不良副作用。目前的发现还为天然和合成的乙酰胆碱酯酶抑制剂的结构-活性关系提供了更多的见解。
• Barger, Journal of the Chemical Society, 1909, vol. 95, p. 2196
  作者：Barger

  DOI：——

  日期：——
• Rosenmund, Chemische Berichte, 1910, vol. 43, p. 311
  作者：Rosenmund

  DOI：——

  日期：——
• Leger, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1906, vol. 142, p. 108
  作者：Leger

  DOI：——

  日期：——